Prevention of Hippocampus Neuronal Damage in lschemic Gerbils by a Novel Lipid Peroxidation Inhibitor (Quinazoline Derivative)

ABSTRACT ABBREVIATIONS: MAP2, microtuble-associated protein 2; PKC, protein kinase C; PDBu, phorbol 12,13-dibutyrate. 90

α-Tocopherol and ubiquinones in rat brain subjected to decapitation ischemia

Levels of α-tocopherol (α-Toc), reduced ubiquinones (QH 2) and oxidized ubiquinones (Q) were assayed in rat forebrain subjected to decapitation ischemia. Post-decapitation levels of α-Toc decreased by 16% at 3 min and 20% at 15 min. Increases in Q 9H 2 (83%) and in Q 10H 2 (107%) were observed immediately following decapitation; thereafter their levels began to decrease and approached to the pre-ischemic values at 15 min. In contrast, Q 9 and Q 10 tended to increase continuously during ischemia. The data indicate that complete ischemia results in distinct changes in the recebral content of lipid-soluble antioxidants. The decrease of α-Toc may make the brain prone to peroxidative attack when cerebral tissue is subsequently reoxygenated