Snake fang-inspired stamping patch for transdermal delivery of liquid formulations

A flexible microneedle patch that can transdermally deliver liquid-phase therapeutics would enable direct use of existing, approved drugs and vaccines, which are mostly in liquid form, without the need for additional drug solidification, efficacy verification, and subsequent approval. Specialized dissolving or coated microneedle patches that deliver reformulated, solidified therapeutics have made considerable advances; however, microneedles that can deliver liquid drugs and vaccines still remain elusive because of technical limitations. Here, we present a snake fang-inspired microneedle patch that can administer existing liquid formulations to patients in an ultrafast manner (< 15 s). Rear-fanged snakes have an intriguing molar with a groove on the surface, which enables rapid and efficient infusion of venom or saliva into prey. Liquid delivery is based on surface tension and capillary action. The microneedle patch uses multiple open groove architectures that emulate the grooved fangs of rear-fanged snakes: Similar to snake fangs, the microneedles can rapidly and efficiently deliver diverse liquid-phase drugs and vaccines in seconds under capillary action with only gentle thumb pressure, without requiring a complex pumping system. Hydrodynamic simulations show that the snake fang-inspired open groove architectures enable rapid capillary force-driven delivery of liquid formulations with varied surface tensions and viscosities. We demonstrate that administration of ovalbumin and influenza virus with the snake fang-inspired microneedle patch induces robust antibody production and protective immune response in guinea pigs and mice

A Phenome-Based Functional Analysis of Transcription Factors in the Cereal Head Blight Fungus, Fusarium graminearum

Fusarium graminearum is an important plant pathogen that causes head blight of major cereal crops. The fungus produces mycotoxins that are harmful to animal and human. In this study, a systematic analysis of 17 phenotypes of the mutants in 657 Fusarium graminearum genes encoding putative transcription factors (TFs) resulted in a database of over 11,000 phenotypes (phenome). This database provides comprehensive insights into how this cereal pathogen of global significance regulates traits important for growth, development, stress response, pathogenesis, and toxin production and how transcriptional regulations of these traits are interconnected. In-depth analysis of TFs involved in sexual development revealed that mutations causing defects in perithecia development frequently affect multiple other phenotypes, and the TFs associated with sexual development tend to be highly conserved in the fungal kingdom. Besides providing many new insights into understanding the function of F. graminearum TFs, this mutant library and phenome will be a valuable resource for characterizing the gene expression network in this fungus and serve as a reference for studying how different fungi have evolved to control various cellular processes at the transcriptional level

Topology Optimization to Reduce Electromagnetic Force Induced Vibration for the Specific Frequency of PMSM Motor Using Electromagnetic-Structural Coupled Analysis

Vibration and noise reduction are very important in electric vehicle driving motors. In this study, topology optimization of housing was performed to reduce vibration in a specific frequency caused by electromagnetic force generated by a permanent magnet synchronous motor (PMSM). The vibration induced by the electromagnetic force of the motor was calculated using electromagnetic-structural coupled analysis. Then, the magnitude of the acceleration for a specific frequency at which peak occurs in the rectangular and circular shape housing concept design model was reduced by using the topology optimization method. As a result, the rectangular and circular shape housing design reduced 92.9% and 96.0%, respectively. Finally, the vibration was effectively reduced while maintaining the electromagnetic characteristics of the motor, for which topology optimization was conducted while not changing the rotor or stator shape design (electromagnetic design factor) but by changing the motor housing shape design (mechanical and structural design factor)

Reliability-Based Robust Design Optimization for Maximizing the Output Torque of Brushless Direct Current (BLDC) Motors Considering Manufacturing Uncertainty

In recent years, the deterministic design optimization method has been widely used to improve the output performance of brushless direct current (BLDC) motors. However, it does not contribute to reducing the failure rate and performance variation of products because it cannot determine the manufacturing uncertainty. In this study, we proposed reliability-based robust design optimization to improve the output torque of a BLDC motor while reducing the failure rate and performance variation. We calculated the output torque and vibration response of the BLDC motor using the electromagnetic–structural coupled analysis. We selected the tooth thickness, slot opening width, slot radius, slot depth, tooth width, magnet thickness, and magnet length as the design variables related to the shape of the stator and rotor that affect the output torque. We considered the distribution of design variables with manufacturing tolerances. We performed a reliability analysis of the BLDC motor considering the distribution of design variables with manufacturing tolerances. Using the reliability analysis results, we performed reliability-based robust design optimization (RBRDO) to maximize the output torque; consequently, the output torque increased by 8.8% compared to the initial BLDC motor, the standard deviation in output performance decreased by 46.9% with improved robustness, and the failure rate decreased by 99.2% with enhanced reliability. The proposed reliability-based robust design optimization is considered to be useful in the actual product design field because it can evaluate both the reliability and robustness of the product and improve its performance in the design stage

Repurposing compact discs as master molds to fabricate high-performance organic nanowire field-effect transistors

Organic field-effect transistors (OFETs) have been developed over the past few decades due to their potential applications in future electronics such as wearable and foldable electronics. As the electrical performance of OFETs has improved, patterning organic semiconducting crystals has become a key issue for their commercialization. However, conventional soft lithographic techniques have required the use of expensive processes to fabricate high-resolution master molds. In this study, we demonstrated a cost-effective method to prepare nanopatterned master molds for the fabrication of high-performance nanowire OFETs. We repurposed commercially available compact discs (CDs) as master molds because they already have linear nanopatterns on their surface. Flexible nanopatterned templates were replicated from the CDs using UV-imprint lithography. Subsequently, 6,13-bis-(triisopropylsilylethynyl) pentacene nanowires (NWs) were grown from the templates using a capillary force-assisted lithographic technique. The NW-based OFETs showed a high average field-effect mobility of 2.04 cm(2) V-1 s(-1). This result was attributed to the high crystallinity of the NWs and to their crystal orientation favorable for charge transport.11sciescopu

Electrohydrodynamic-Jet (EHD)-Printed Diketopyrrolopyroole-Based Copolymer for OFETs and Circuit Applications

We report the employment of an electrohydrodynamic-jet (EHD)-printed diketopyrrolopyrrole-based copolymer (P-29-DPPDTSE) as the active layer of fabricated organic field-effect transistors (OFETs) and circuits. The device produced at optimal conditions showed a field-effect mobility value of 0.45 cm2/(Vs). The morphologies of the printed P-29-DPPDTSE samples were determined by performing optical microscopy, X-ray diffraction, and atomic force microscopy experiments. In addition, numerical circuit simulations of the optimal printed P-29-DPPDTSE OFETs were done in order to observe how well they would perform in a high-voltage logic circuit application. The optimal printed P-29-DPPDTSE OFET showed a 0.5 kHz inverter frequency and 1.2 kHz ring oscillator frequency at a 40 V supply condition, indicating the feasibility of its use in a logic circuit application at high voltage

Ambipolar charge transport of diketopyrrolepyrrole-silole-based copolymers and effect of side chain engineering: Compact model parameter extraction strategy for high-voltage logic applications

The copolymers P24DPP-silole and P29DPP-silole, each composed of diketopyrrolopyrrole (DPP) and silole derivatives, were synthesized using a Stille coupling reaction, and their electrical performances in organic field-effect transistors (OFETs) and circuits were investigated. While both the as-spun OFETs exhibited quite low field-effect hole mobility values, the OFETs subjected to thermal annealing at 150 °C exhibited typical ambipolar transport characteristics with average hole and electron mobility values of 1 × 10−1 cm2/(V s) and 2 × 10−3 cm2/(V s). Because the compact model was necessary to perform circuit design with the synthesized OFETs, a strategy for extracting compact model parameters was proposed for high-voltage logic circuit applications by using the industry standard compact Berkeley short-channel IGFET model (BSIM). © 201711Nsciescopu

Rapid custom prototyping of soft poroelastic biosensor for simultaneous epicardial recording and imaging

Printed biosensors are important for health monitoring and research purposes. Here, the authors report on the development of a soft poroelastic silicone based sensor which can be easily printed and is resistant to mechanical strain hysteresis, allowing for more accurate electrophysiology readings and imaging