599 research outputs found
MPSeg : Multi-Phase strategy for coronary artery Segmentation
Accurate segmentation of coronary arteries is a pivotal process in assessing
cardiovascular diseases. However, the intricate structure of the cardiovascular
system presents significant challenges for automatic segmentation, especially
when utilizing methodologies like the SYNTAX Score, which relies extensively on
detailed structural information for precise risk stratification. To address
these difficulties and cater to this need, we present MPSeg, an innovative
multi-phase strategy designed for coronary artery segmentation. Our approach
specifically accommodates these structural complexities and adheres to the
principles of the SYNTAX Score. Initially, our method segregates vessels into
two categories based on their unique morphological characteristics: Left
Coronary Artery (LCA) and Right Coronary Artery (RCA). Specialized ensemble
models are then deployed for each category to execute the challenging
segmentation task. Due to LCA's higher complexity over RCA, a refinement model
is utilized to scrutinize and correct initial class predictions on segmented
areas. Notably, our approach demonstrated exceptional effectiveness when
evaluated in the Automatic Region-based Coronary Artery Disease diagnostics
using x-ray angiography imagEs (ARCADE) Segmentation Detection Algorithm
challenge at MICCAI 2023.Comment: MICCAI 2023 Conference ARCADE Challeng
SSASS: Semi-Supervised Approach for Stenosis Segmentation
Coronary artery stenosis is a critical health risk, and its precise
identification in Coronary Angiography (CAG) can significantly aid medical
practitioners in accurately evaluating the severity of a patient's condition.
The complexity of coronary artery structures combined with the inherent noise
in X-ray images poses a considerable challenge to this task. To tackle these
obstacles, we introduce a semi-supervised approach for cardiovascular stenosis
segmentation. Our strategy begins with data augmentation, specifically tailored
to replicate the structural characteristics of coronary arteries. We then apply
a pseudo-label-based semi-supervised learning technique that leverages the data
generated through our augmentation process. Impressively, our approach
demonstrated an exceptional performance in the Automatic Region-based Coronary
Artery Disease diagnostics using x-ray angiography imagEs (ARCADE) Stenosis
Detection Algorithm challenge by utilizing a single model instead of relying on
an ensemble of multiple models. This success emphasizes our method's capability
and efficiency in providing an automated solution for accurately assessing
stenosis severity from medical imaging data.Comment: MICCAI 2023 Conference ARCADE Challeng
Changes in the Outdoor Wear Market: Focused on the South Korean Market
People have become interested in wellness and health, which has led to well-being trends and increased participation in activities. Therefore, the outdoor wear market has shown growth for several years. However, the outdoor wear market of South Korea is becoming saturated. Moreover, Outdoor wear consumers are tired of same design products. The sportswear companies are trying to develop athleisure products. Therefore, it is time to develop outdoor products for emotional approach. According to results, when consumers purchase outdoor wear, they consider the functionality of the materials more than they do when purchasing ordinary clothes. Outdoor wear consumers\u27 pursued images were classified into three types: urban, minimalist, and active. Outdoor wear selection criteria were classified into two types: instrumental function and expressive function. Outdoor wear brands need to qualify their products functionally and meet their segmented consumers\u27 demands by developing products depending on their image from the planning stage
High resolution crystal structure of PedB: a structural basis for the classification of pediocin-like immunity proteins
<p>Abstract</p> <p>Background</p> <p>Pediocin-like bacteriocins, ribosomally-synthesized antimicrobial peptides, are generally coexpressed with cognate immunity proteins in order to protect the bacteriocin-producer from its own bacteriocin. As a step for understanding the mode of action of immunity proteins, we determined the crystal structure of PedB, a pediocin-like immunity protein conferring immunity to pediocin PP-1.</p> <p>Results</p> <p>The 1.6 Å crystal structure of PedB reveals that PedB consists of an antiparallel four-helix bundle with a flexible C-terminal end. PedB shows structural similarity to an immunity protein against enterocin A (EntA-im) but some disparity to an immunity protein against carnobacteriocin B2 (ImB2) in both the C-terminal conformation and the local structure constructed by α3, α4, and their connecting loop. Structure-inspired mutational studies reveal that deletion of the last seven residues of the C-terminus of PedB almost abolished its immunity activity.</p> <p>Conclusion</p> <p>The fact that PedB, EntA-im, and ImB2 share a four-helix bundle structure strongly suggests the structural conservation of this motif in the pediocin-like immunity proteins. The significant difference in the core structure and the C-terminal conformation provides a structural basis for the classification of pediocin-like immunity proteins. Our mutational study using C-terminal-shortened PedBs and the investigation of primary sequence of the C-terminal region, propose that several polar or charged residues in the extreme C-terminus of PedB which is crucial for the immunity are involved in the specific recognition of pediocin PP-1.</p
Two novel mutations of Wiskott–Aldrich syndrome: the molecular prediction of interaction between the mutated WASP L101P with WASP-interacting protein by molecular modeling
AbstractWiskott–Aldrich syndrome (WAS) is an X-linked disorder characterized by eczema, thrombocytopenia and increased susceptibility of infections, with mutations of the WAS gene being responsible for WAS and X-linked thrombocytopenia. Herein, two novel mutations of WAS at T336C on exon 3, and at 1326–1329, a G deletion on exon 10, resulting in L101P missense mutation and frameshift mutation 444 stop, respectively, are reported. The affected patients with either mutation showed severe suppression of WAS protein (WASP) levels, T cell proliferation, and CFSE-labeled T cells division. Because WASP L101 have not shown direct nuclear Overhauser effect (NOE) contact with the WASP-interacting protein (WIP) in NMR spectroscopy, molecular modeling was performed to evaluate the molecular effect of WASP P101 to WIP peptide. It is presumed that P101 induced a conformational change in the Q99 residue of WASP and made the side chain of Q99 move away from the WIP peptide, resulting in disruption of the hydrogen bond between Q99 WASP and Y475 WIP. A possible model for the molecular pathogenesis of WAS has been proposed by analyzing the interactions of WASP and WIP using a molecular modeling study
Commercial video games and cognitive functions: video game genres and modulating factors of cognitive enhancement
Background
Unlike the emphasis on negative results of video games such as the impulsive engagement in video games, cognitive training studies in individuals with cognitive deficits showed that characteristics of video game elements were helpful to train cognitive functions. Thus, this study aimed to have a more balanced view toward the video game playing by reviewing genres of commercial video games and the association of video games with cognitive functions and modulating factors. Literatures were searched with search terms (e.g. genres of video games, cognitive training) on database and Google scholar.
Results
video games, of which purpose is players entertainment, were found to be positively associated with cognitive functions (e.g. attention, problem solving skills) despite some discrepancy between studies. However, the enhancement of cognitive functions through video gaming was limited to the task or performance requiring the same cognitive functions. Moreover, as several factors (e.g. age, gender) were identified to modulate cognitive enhancement, the individual difference in the association between video game playing and cognitive function was found.
Conclusion
Commercial video games are suggested to have the potential for cognitive function enhancement. As understanding the association between video gaming and cognitive function in a more balanced view is essential to evaluate the potential outcomes of commercial video games that more people reported to engage, this review contributes to provide more objective evidence for commercial video gaming.It was supported by a grant from Game Science Forum in South Kore
Cerebral Infarction in IgG Multiple Myeloma with Hyperviscosity
Cerebral infarction is an uncommon complication in multiple myeloma with hyperviscosity. Serum hyperviscosity may cause a variety of clinical manifestations including bleeding from mucosal membranes, congestive heart failure, retinopathy, and various neurologic deficits. These manifestations have been attributed to the presence of large quantities of asymmetrical molecules of high molecular weight in the serum. We recently experienced a case of multiple myeloma with acute cerebral infarction, which caused by hyperviscosity, as an initial manifestation in IgG multiple myeloma, and reviewed the relevant literature of myeloma presenting with the stroke. A 68-yr-old woman abruptly developed hypesthesia and monoplegia in the left leg. The stroke confirmed by the brain MRI and MR angiography, which revealed acute infarction at the right anterior cerebral artery territory. On admission, routine blood tests showed a slight decrease in hemoglobin and a marked increase in erythrocyte sedimentation rate. Peripheral blood smear, serum protein electrophoresis, serum visocity, and bone marrow aspiration showed that she had IgG multiple myeloma with hyperviscosity. She was treated by chemotherapy with cyclophosphamide and discharged with the improved clinical condition
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