Progressive Processing of Continuous Range Queries in Hierarchical Wireless Sensor Networks

In this paper, we study the problem of processing continuous range queries in a hierarchical wireless sensor network. Contrasted with the traditional approach of building networks in a "flat" structure using sensor devices of the same capability, the hierarchical approach deploys devices of higher capability in a higher tier, i.e., a tier closer to the server. While query processing in flat sensor networks has been widely studied, the study on query processing in hierarchical sensor networks has been inadequate. In wireless sensor networks, the main costs that should be considered are the energy for sending data and the storage for storing queries. There is a trade-off between these two costs. Based on this, we first propose a progressive processing method that effectively processes a large number of continuous range queries in hierarchical sensor networks. The proposed method uses the query merging technique proposed by Xiang et al. as the basis and additionally considers the trade-off between the two costs. More specifically, it works toward reducing the storage cost at lower-tier nodes by merging more queries, and toward reducing the energy cost at higher-tier nodes by merging fewer queries (thereby reducing "false alarms"). We then present how to build a hierarchical sensor network that is optimal with respect to the weighted sum of the two costs. It allows for a cost-based systematic control of the trade-off based on the relative importance between the storage and energy in a given network environment and application. Experimental results show that the proposed method achieves a near-optimal control between the storage and energy and reduces the cost by 0.989~84.995 times compared with the cost achieved using the flat (i.e., non-hierarchical) setup as in the work by Xiang et al.Comment: 41 pages, 20 figure

Mono-allelic retrotransposon insertion addresses epigenetic transcriptional repression in human genome

Background: Retrotransposons have been extensively studied in plants and animals and have been shown to have an impact on human genome dynamics and evolution. Their ability to move within genomes gives retrotransposons to affect genome instability. Methods: we examined the polymorphic inserted AluYa5, evolutionary young Alu, in the progesterone receptor gene to determine the effects of Alu insertion on molecular environment. We used mono-allelic inserted cell lines which carry both Alu-present and Alu-absent alleles. To determine the epigenetic change and gene expression, we performed restriction enzyme digestion, Pyrosequencing, and Chromatin Immunoprecipitation. Results: We observed that the polymorphic insertion of evolutionally young Alu causes increasing levels of DNA methylation in the surrounding genomic area and generates inactive histone tail modifications. Consequently the Alu insertion deleteriously inactivates the neighboring gene expression. Conclusion: The mono-allelic Alu insertion cell line clearly showed that polymorphic inserted repetitive elements cause the inactivation of neighboring gene expression, bringing aberrant epigenetic changes

EUTROPHICATION OF THE MAJOR RESERVOIRS IN KOREA

Trophic state of several major reservoirs in Korea are reviewed. Most of large reservoirs are mesotrophic to eutrophic, suffering bluegreen algal blooms. Recently many reservoirs are being eutrophied at high rate mainly due to the increase of excretion by livestock in watershed and netcage-type fishfarms within the lake basins. The trophic state changes of Lake Soyang, from oligotrophy to eutrophy in recent 10 years, are presented as a case study of rapid eutrophication. Chlorophyll a concentration increased from ca. 3mg/m³ in early 1980s to 15 mg/m³ in 1989. The dominant phytoplankton species in summer are changed from Peridinium to Anabaena since 1986 and the standing crop of Anabaena has been increasing. Secchidisc depth decreased from 5 to 1m. TP increased from 7 to 20 mgP/m³. The rate of hypolimnetic oxygen deficit increased year to year from 0.028 mgO₂/cm²/day in 1986 to 0.094 in 1989. Fishfarms within the lake are the major phosphorus source in Lake Soyang exceeding the total phosphorus loading from the watershed. This high rate of eutrophication is expected to persist in next decade.Article信州大学理学部付属諏訪臨湖実験所報告 7: 21-29(1991)departmental bulletin pape

Protective effect of genistein on radiation-induced intestinal injury in tumor bearing mice

BACKGROUND: Radiation therapy is the most widely used treatment for cancer, but it causes the side effect of mucositis due to intestinal damage. We examined the protective effect of genistein in tumor-bearing mice after abdominal irradiation by evaluation of apoptosis and intestinal morphological changes. METHODS: Mouse colon cancer CT26 cells were subcutaneously injected at the flank of BALB/c mice to generate tumors. The tumor-bearing mice were treated with abdominal radiation at 5 and 10 Gy, and with genistein at 200 mg/kg body weight per day for 1 d before radiation. The changes in intestinal histology were evaluated 12 h and 3.5 d after irradiation. To assess the effect of the combination treatment on the cancer growth, the tumor volume was determined at sacrifice before tumor overgrowth occurred. RESULTS: Genistein significantly decreased the number of apoptotic nuclei compared with that in the irradiation group 12 h after 5 Gy irradiation. Evaluation of histological changes showed that genistein ameliorated intestinal morphological changes such as decreased crypt survival, villus shortening, and increased length of the basal lamina 3.5 d after 10 Gy irradiation. Moreover, the genistein-treated group exhibited more Ki-67-positive proliferating cells in the jejunum than the irradiated control group, and crypt depths were greater in the genistein-treated group than in the irradiated control group. The mean weight of the CT26 tumors was reduced in the group treated with genistein and radiation compared with the control group. CONCLUSION: Genistein had a protective effect on intestinal damage induced by irradiation and delayed tumor growth. These results suggest that genistein is a useful candidate for preventing radiotherapy-induced intestinal damage in cancer patients