The Effect of Anxiety Disorders on Smoking Cessation in Cancer Patients

https://openworks.mdanderson.org/sumexp23/1125/thumbnail.jp

The Relationships of Childhood Trauma and Post Traumatic Stress Disorder to Smoking Outcomes in Cancer Patients

https://openworks.mdanderson.org/sumexp22/1105/thumbnail.jp

Effected Cancer Region and Psychiatric Disorders in Smoking Cessation

https://openworks.mdanderson.org/sumexp23/1003/thumbnail.jp

The Role of Depression on the Ability to Achieve Smoking Abstinence​

We investigated how depression affects smoking abstinence among cancer patients who participated in MD Anderson Cancer Center\u27s Tobacco Research and Treatment Program (TRTP), assessing outcomes three months post-enrollment. We also compared the likelihood of abstaining from smoking while accounting for nicotine dependence measured by the Fagerström Test for Cigarette Dependence (FTCD). The findings aimed to guide clinical practices in optimizing treatment of tobacco use disorder (TUD) to improve abstinence rates. Integrating comprehensive treatments for depression alongside standard TUD treatment holds promise for improving overall abstinence outcomes.https://openworks.mdanderson.org/stronger24/1005/thumbnail.jp

Deep Sequencing of Candidate Genes Identified 14 Variants Associated with Smoking Abstinence in an Ethnically Diverse Sample

Despite the large public health toll of smoking, genetic studies of smoking cessation have been limited with few discoveries of risk or protective loci. We investigated common and rare variant associations with success in quitting smoking using a cohort from 8 randomized controlled trials involving 2231 participants and a total of 10,020 common and 24,147 rare variants. We identified 14 novel markers including 6 mapping to genes previously related to psychiatric and substance use disorders, 4 of which were protective (CYP2B6 (rs1175607105), HTR3B (rs1413172952; rs1204720503), rs80210037 on chr15), and 2 of which were associated with reduced cessation (PARP15 (rs2173763), SCL18A2 (rs363222)). The others mapped to areas associated with cancer including FOXP1 (rs1288980) and ZEB1 (rs7349). Network analysis identified significant canonical pathways for the serotonin receptor signaling pathway, nicotine and bupropion metabolism, and several related to tumor suppression. Two novel markers (rs6749438; rs6718083) on chr2 are flanked by genes associated with regulation of bodyweight. The identification of novel loci in this study can provide new targets of pharmacotherapy and inform efforts to develop personalized treatments based on genetic profiles

Impact of Treating Insomnia Symptoms on Abstinence from Smoking

https://openworks.mdanderson.org/sumexp21/1034/thumbnail.jp

Individual differences in late positive potential amplitude and theta power predict cue-induced eating

Cue-induced reward-seeking behaviors are regulated by both the affective and cognitive control systems of the brain. This study aimed at investigating how individual differences in affective and cognitive responses to cues predicting food rewards contribute to the regulation of cue-induced eating. We recorded electroencephalogram (EEG) from 59 adults while they viewed emotional and food-related images that preceded the delivery of food rewards (candies) or non-food objects (beads). We measured the amplitude of the late positive potential (LPP) in response to a variety of motivationally relevant images and power in the theta (4-8 Hz) frequency band after candies or beads were dispensed to the participants. We found that individuals with larger LPP responses to food images than to pleasant images (C>P group) ate significantly more during the experiment than those with the opposite response pattern (P>C group, p qBE) ate significantly more than those with the opposite response pattern (qBE>qCA, p C and qBE>qCA group ate less (p < 0.001) than did the other three groups formed by crossing the LPP and theta group assignments, who exhibited similar eating behavior on average (p = 0.662). These findings demonstrate that individual differences in both affective and cognitive responses to reward-related cues underlie vulnerability to cue-induced behaviors, underscoring the need for individualized treatments to mitigate maladaptive behaviors

Association Between Quitting Smoking and Survival in Cancer Patients

https://openworks.mdanderson.org/sumexp21/1010/thumbnail.jp

Relationship Quality and Burden among Caregivers for Late-stage Cancer Patients

Objective This study explores how caregiver relationship quality with family, patient, and patient’s health care provider (HCP) is associated with subjective caregiver burden during the early treatment phase for late-stage cancer. Method Burden and relationship quality were assessed in telephone interviews with family caregivers (FCGs) of advanced cancer patients. The five subscales of the Caregiver Reaction Assessment measured burden, while relationships were measured with the Family Relationship Index, the Family Inventory of Needs subscale of met needs, and a scale assessing family discord in cancer communication. Results Multiple linear regression analyses in SPSS (v16) of 420 FCGs showed that higher quality relationship with family was associated with lower burden in FCG abandonment, health, scheduling (

Relationship Quality and Burden among Caregivers for Late-stage Cancer Patients

Objective This study explores how caregiver relationship quality with family, patient, and patient’s health care provider (HCP) is associated with subjective caregiver burden during the early treatment phase for late-stage cancer. Method Burden and relationship quality were assessed in telephone interviews with family caregivers (FCGs) of advanced cancer patients. The five subscales of the Caregiver Reaction Assessment measured burden, while relationships were measured with the Family Relationship Index, the Family Inventory of Needs subscale of met needs, and a scale assessing family discord in cancer communication. Results Multiple linear regression analyses in SPSS (v16) of 420 FCGs showed that higher quality relationship with family was associated with lower burden in FCG abandonment, health, scheduling (