8,637 research outputs found

    Chandra Observation of NGC 1559: Eight Ultraluminous X-ray Sources Including a Compact Binary Candidate

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    Despite the 30-year history of ultra-luminous X-ray sources (ULXs) studies, issues like the majority of their physical natures (i.e., neutron stars, stellar-mass black holes, or intermediate black holes) as well as the accretion mechanisms are still under debate. Expanding the ULX sample size in the literature is clearly a way to help. To this end, we investigated the X-ray source population, ULXs in particular, in the barred spiral galaxy NGC 1559 using a Chandra observation made in 2016. In this 45-ks exposure, 33 X-ray point sources were detected within the 2.'7 isophotal radius of the galaxy. Among them, 8 ULXs were identified with the criterion of the X-ray luminosity Lx>1039L_x>10^{39} erg s1^{-1} (0.3-7~keV). Both X-ray light curves and spectra of all the sources were examined. Except for some low-count spectra that only provide ambiguous spectral fitting results, all the X-ray sources were basically spectrally hard and therefore likely have non-thermal origins. While no strong X-ray variability was present in most of the sources owing to the relatively short exposure of the observation, we found an intriguing ULX, named X-24, exhibiting a periodicity of \sim7500s with a detection significance of 2.7σ\sigma. We speculate that it is the orbital period of the system. Roche-lobe over flow and Roche limit are consistent with the speculation. Thus, we suggest that X-24 may be the one of the rare compact binary ULXs, and hence, a good candidate as a stellar-mass black hole.Comment: Accepted for publication in Ap

    Keratin 8 phosphorylation regulates its transamidation and hepatocyte Mallory‐Denk body formation

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    Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154269/1/fsb2026006010.pd

    Compressive Sensing-Based Grant-Free Massive Access for 6G Massive Communication

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    The advent of the sixth-generation (6G) of wireless communications has given rise to the necessity to connect vast quantities of heterogeneous wireless devices, which requires advanced system capabilities far beyond existing network architectures. In particular, such massive communication has been recognized as a prime driver that can empower the 6G vision of future ubiquitous connectivity, supporting Internet of Human-Machine-Things for which massive access is critical. This paper surveys the most recent advances toward massive access in both academic and industry communities, focusing primarily on the promising compressive sensing-based grant-free massive access paradigm. We first specify the limitations of existing random access schemes and reveal that the practical implementation of massive communication relies on a dramatically different random access paradigm from the current ones mainly designed for human-centric communications. Then, a compressive sensing-based grant-free massive access roadmap is presented, where the evolutions from single-antenna to large-scale antenna array-based base stations, from single-station to cooperative massive multiple-input multiple-output systems, and from unsourced to sourced random access scenarios are detailed. Finally, we discuss the key challenges and open issues to shed light on the potential future research directions of grant-free massive access.Comment: Accepted by IEEE IoT Journa

    Whole-Genome Sequencing to Identify Mutants and Polymorphisms in Chlamydomonas reinhardtii

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    Whole-genome sequencing (WGS) provides a new platform for the identification of mutations that produce a mutant phenotype. We used Illumina sequencing to identify the mutational profile of three Chlamydomonas reinhardtii mutant strains. The three strains have more than 38,000 changes from the reference genome. NG6 is aflagellate and maps to 269 kb with only one nonsynonymous change; the V12E mutation falls in the FLA8 gene. Evidence that NG6 is a fla8 allele comes from swimming revertants that are either true or pseudorevertants. NG30 is aflagellate and maps to 458 kb that has six nonsynonomous changes. Evidence that NG30 has a causative nonsense allele in IFT80 comes from rescue of the nonswimming phenotype with a fragment bearing only this gene. This gene has been implicated in Jeune asphyxiating thoracic dystrophy. Electron microscopy of ift80-1 (NG30) shows a novel basal body phenotype. A bar or cap is observed over the distal end of the transition zone, which may be an intermediate in preparing the basal body for flagellar assembly. In the acetate-requiring mutant ac17, we failed to find a nonsynonymous change in the 676 kb mapped region, which is incompletely assembled. In these strains, 43% of the changes occur on two of the 17 chromosomes. The excess on chromosome 6 surrounds the mating-type locus, which has numerous rearrangements and suppressed recombination, and the changes extend beyond the mating-type locus. Unexpectedly, chromosome 16 shows an unexplained excess of single nucleotide polymorphisms and indels. Overall, WGS in combination with limited mapping allows fast and accurate identification of point mutations in Chlamydomonas

    Land use policy and spatiotemporal changes in the water area of an arid region

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    In this study, we developed a framework to analyze the impact of land use policies on water area changes. We used quantitative and qualitative approaches in our model, including Delphi method, Moran's I, 3D kernel density surface (3D-KDS) technique, and orthogonalized regression. The model facilitates visual examination of spatiotemporal patterns in water area changes and identification of the net effect of land use policies on water area changes. We consider three types of land use policy and four control variables which include water management policy and climate change factors to test the model by using data from Ejina, an oasis area from Inner Mongolia, China. The results of both 3D-KDS and Moran's I coefficient showed distinctive patterns in negative and positive water area changes. Standardized coefficients from the augmented orthogonalized ordinary least squares (OLS) models helped isolate the net effects of the three types of land use policy on negative and positive water area changes. Land use policies had greater impact on hydrological environment changes than water management policy and climate change factors. Our model can be utilized to assess the effectiveness of land use policies in an area and aid in helpful in monitoring the implementation of existing policies and design of new land use policies.The authors are indebted to the National Natural Science Fund (41571162) and Advantage Discipline Construction Project of Jiangsu Province

    Contribution of transcriptional regulation to natural variations in Arabidopsis

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    BACKGROUND: Genetic control of gene transcription is a key component in genome evolution. To understand the transcriptional basis of natural variation, we have studied genome-wide variations in transcription and characterized the genetic variations in regulatory elements among Arabidopsis accessions. RESULTS: Among five accessions (Col-0, C24, Ler, WS-2, and NO-0) 7,508 probe sets with no detectable genomic sequence variations were identified on the basis of the comparative genomic hybridization to the Arabidopsis GeneChip microarray, and used for accession-specific transcriptome analysis. Two-way ANOVA analysis has identified 60 genes whose mRNA levels differed in different accession backgrounds in an organ-dependent manner. Most of these genes were involved in stress responses and late stages of plant development, such as seed development. Correlation analysis of expression patterns of these 7,508 genes between pairs of accessions identified a group of 65 highly plastic genes with distinct expression patterns in each accession. CONCLUSION: Genes that show substantial genetic variation in mRNA level are those with functions in signal transduction, transcription and stress response, suggesting the existence of variations in the regulatory mechanisms for these genes among different accessions. This is in contrast to those genes with significant polymorphisms in the coding regions identified by genomic hybridization, which include genes encoding transposon-related proteins, kinases and disease-resistance proteins. While relatively fewer sequence variations were detected on average in the coding regions of these genes, a number of differences were identified from the upstream regions, several of which alter potential cis-regulatory elements. Our results suggest that nucleotide polymorphisms in regulatory elements of genes encoding controlling factors could be primary targets of natural selection and a driving force behind the evolution of Arabidopsis accessions
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