Ethyl 5-Oxo-5-(((12-oxoindolo[2,1-<i>b</i>]quinazolin-6(12<i>H</i>)-ylidene)amino)oxy)pentanoate

Indolo[2,1-b]quinazolin-6,12-dione (tryptanthrin) derivatives present important types of nitrogen-containing heterocyclic compounds which are useful intermediate products in organic synthesis and have potential pharmaceutical applications. The new ethyl 5-oxo-5-(((12-oxoindolo[2,1-b]quinazolin-6(12H)-ylidene)amino)oxy)pentanoate (Compound 2) was synthesized. Compound 2 is the first example of a tryptanthrin derivative containing a dicarboxylic acid residue in the side chain. The Z,E-isomerism of Compound 2 was investigated by DFT calculations. Bioavailability was evaluated in silico using ADME predictions. According to the ADME results, Compound 2 is potentially highly bioavailable and has the prospective to be used as the main component for the development of anti-inflammatory drugs

Ethyl 5-Oxo-5-(((12-oxoindolo[2,1-b]quinazolin-6(12H)-ylidene)amino)oxy)pentanoate

Indolo[2,1-b]quinazolin-6,12-dione (tryptanthrin) derivatives present important types of nitrogen-containing heterocyclic compounds which are useful intermediate products in organic synthesis and have potential pharmaceutical applications. The new ethyl 5-oxo-5-(((12-oxoindolo[2,1-b]quinazolin-6(12H)-ylidene)amino)oxy)pentanoate (Compound 2) was synthesized. Compound 2 is the first example of a tryptanthrin derivative containing a dicarboxylic acid residue in the side chain. The Z,E-isomerism of Compound 2 was investigated by DFT calculations. Bioavailability was evaluated in silico using ADME predictions. According to the ADME results, Compound 2 is potentially highly bioavailable and has the prospective to be used as the main component for the development of anti-inflammatory drugs

Structure of Late Pleistocene and Holocene Sediments in the Petrozavodsk Bay, Lake Onego (NW Russia)

Here, we present new results from seismic, geological, and geochemical studies conducted in 2015–2019 in the Petrozavodsk Bay of Lake Onego, NW Russia. The aims of these investigations were to (i) to characterize the structure of Quaternary deposits and (ii) provide new evidence of modern geodynamic movements and gas-seepage in Holocene sediments. The structure of the recovered deposits was composed of lacustrine mud, silt and sands from the Holocene, limno-glacial clays (varved clays) from the Late Glacial–Interglacial Transition, and glacial deposits (till) from the Late Pleistocene. The thickness of these deposits varied in different parts of the bay. Many pockmarks created by gases escaping and reaching sediment-water interface were observed in these deposits. Such pockmarks can play a significant role in the geochemical and biological processes in the bottom sediment surface, and gases that escape might modify the physicochemical characteristics of the environment