On energy consumption of switch-centric data center networks

Data center network (DCN) is the core of cloud computing and accounts for 40% energy spend when compared to cooling system, power distribution and conversion of the whole data center (DC) facility. It is essential to reduce the energy consumption of DCN to esnure energy-efficient (green) data center can be achieved. An analysis of DC performance and efficiency emphasizing the effect of bandwidth provisioning and throughput on energy proportionality of two most common switch-centric DCN topologies: three-tier (3T) and fat tree (FT) based on the amount of actual energy that is turned into computing power are presented. Energy consumption of switch-centric DCNs by realistic simulations is analyzed using GreenCloud simulator. Power related metrics were derived and adapted for the information technology equipment (ITE) processes within the DCN. These metrics are acknowledged as subset of the major metrics of power usage effectiveness (PUE) and data center infrastructure efficiency (DCIE), known to DCs. This study suggests that despite in overall FT consumes more energy, it spends less energy for transmission of a single bit of information, outperforming 3T

Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma: final results of EORTC 18991, a randomised phase III trial

Background Any benefit of adjuvant interferon alfa-2b for melanoma could depend on dose and duration of treatment. Our aim was to determine whether pegylated interferon alfa-2b can facilitate prolonged exposure while maintaining tolerability. Methods 1256 patients with resected stage III melanoma were randomly assigned to observation (n=629) or pegylated interferon alfa-2b (n=627) 6 pg/kg per week for 8 weeks (induction) then 3 pg/kg per week (maintenance) for an intended duration of 5 years. Randomisation was stratified for microscopic (N1) versus macroscopic (N2) nodal involvement, number of positive nodes, ulceration and tumour thickness, sex, and Centre. Randomisation was done with a minimisation technique. The primary endpoint was recurrence-free survival. Analyses were done by intention to treat. This study is registered with ClinicalTrials.gov, number NCT00006249. Findings All randomised patients were included in the primary efficacy analysis. 608 patients in the interferon group and 613 patients in the observation group were included in safety analyses. The median length of treatment with pegylated interferon alfa-2b was 12 (IQR 3.8-33-4) months. At 3.8 (3.2-4.2) years median follow-up, 328 recurrence events had occurred in the interferon group compared with 368 in the observation group (hazard ratio 0 . 82, 95% CI 0 . 71-0.96; p=0 . 01); the 4-year rate of recurrence-free survival was 45.6% (SE 2.2) in the interferon group and 38.9% (2.2) in the observation group. There was no difference in overall survival between the groups. Grade 3 adverse events occurred in 246 (40%) patients in the interferon group and 60 (10%) in the observation group; grade 4 adverse events occurred in 32 (5%) patients in the interferon group and 14 (2%) in the observation group. In the interferon group, the most common grade 3 or 4 adverse events were fatigue (97 patients, 16%), hepatotoxicity (66, 11%), and depression (39, 6%). Treatment with pegylated interferon alfa-2b was discontinued because of toxicity in 191 (31%) patients. Interpretation Adjuvant pegylated interferon alfa-2b for stage III melanoma has a significant, sustained effect on recurrence-free survival. Funding Schering Plough Research International