The phenomenon of multiculturalism in the regional strategizing

The purpose of the article is to justify the possibility of the modernizing development of the region based on the rational use of the potential of a mixed economy of its territories. In contrast to the existing ideas about multiculturalism as a problem, demonstrating the structural imbalances in the economy of the region, the authors view it as a phenomenon that allows the region to provide a competitive advantage. The methodological base of this study is the convergence of the system, synergistic, institutional and endogenous approaches, and sharing a number of theories - growth poles, territorial industrial clusters, balanced development. The article shows the role of the institutional environment in realizing the potential of a diversified economy in the region. It formulates conceptual positions of the mechanism of regional strategizing aimed at the development of relations between territories with the different types of lifestyles. The basis of the interactions is the consensus of economic interests, compromise of competitive aspirations and market positions of the entities as equal partners. It is concluded that there is the need to change the existing system of regional strategizing in terms of strengthening its focus on the formation of the institutional channels for the communication of corporate, small-scale and farm structures. The recommendations on the potential of the mixed economy of the regions were used in the development of the Strategy of investment development for the Rostov region until 2020

ПОЛИМОРФИЗМ ГЕНА ABCG2 У БОЛЬНЫХ ПОДАГРОЙ В ЗАБАЙКАЛЬСКОМ КРАЕ

Aim. To study the frequency distribution of alleles and genotypes of the C421A locus (rs2231142, Q141K) of the ABCG2 gene in patients with gout and to evaluate their association with the risk of the disease development.Methods. 80 patients (69 men and 11 women) with gout (mean age 54.8±12.4 years) were examined. Gout was diagnosed according to the ACR/EULAR classification criteria, 2015. The material for the study was DNA isolated from leukocytes of the whole peripheral blood. All patients were genotyped to detect polymorphism of the C421A locus (rs2231142, Q141K) of the ABCG2 gene. Statistical data processing was performed using Statistica 10.0 statistical software package.Results. The results of the study of the C421A polymorphism (rs2231142, Q141K) of the ABCG2 gene demonstrated a high frequency of mutant A (χ2 = 5.58, p = 0.018, OR = 3.5, CI95% = 1.16–10.52) genotypes C/A (χ2 = 5.03, p = 0.024, OR = 3.5, CI95% = 1.11–10.98) among patients with gout compared with the control group. This fact indicates the significance of the ABCG2 gene rs2231142 locus in the development of gout and allows us to consider the carriage of the minor (A) allele and the C/A genotype as a molecular genetic factor in the development of the disease. The carriage of the wild-type allele (C) and the C/C genotype has a protective character, reducing the risk of developing the disease by 3.5 times.Conclusion. ABCG2 C421A (rs2231142, Q141K) is associated with a high risk of developing gout among population of Zabaikalsky Krai. ABCG2 gene polymorphism can be considered as a genetic predictor of a higher risk of developing gout.Цель. Изучить распределение частот аллелей и генотипов локуса С421A (rs2231142, Q141K) гена ABCG2 у больных подагрой и оценить их ассоциацию с риском развития заболевания.Материалы и методы. Обследовано 80 пациентов (69 мужчин и 11 женщин) с подагрой (средний возраст 54,8±12,4 лет). Диагноз подагры выставлен согласно классификационным критериям ACR/EULAR, 2015. Материалом для исследования являлась ДНК, выделенная из лейкоцитов цельной периферической крови. Все пациенты были генотипированы для выявления полиморфизма локуса С421A (rs2231142, Q141K) гена ABCG2. Статистическая обработка данных проводилась с помощью пакета статистических программ Statistica 10,0. Результаты. Полученные результаты исследования полиморфизма С421A (rs2231142, Q141K) гена ABCG2 продемонстрировали высокую частоту встречаемости мутантного аллеля А (χ2 = 5,58, р = 0,018, OR = 3,5, CI95% = 1,16–10,52) и генотипа С/А (χ2 = 5,03, р = 0,024, OR = 3,5, CI95% = 1,11–10,98) среди больных подагрой по сравнению с группой контроля. Данный факт указывает на значимость локуса rs2231142 гена ABCG2 в развитии подагры и позволяет рассматривать носительство минорного (А) аллеля и генотипа С/А как молекулярно-генетический фактор развития заболевания. Носительство же аллеля дикого типа (С) и генотипа C/С оказывает протективный характер, снижая риск развития заболевания в 3,5 раза.Заключение. ABCG2 С421A (rs2231142, Q141K) ассоциирован с высоким риском развития подагры в популяции жителей Забайкальского края. Полиморфизм гена ABCG2 может рассматриваться как генетический предиктор более высокого риска развития подагры

Heart rate-lowering therapy in gout patients with stable coronary artery disease: focus on ivabradine

Aim. To study the effect of ivabradine and bisoprolol on cardiac hemodynamics and diastolic remodeling in gout patients with coronary artery disease and hypertension and without left ventricular systolic dysfunction.Material and methods. The open randomized parallel clinical trial of 35 men with intercritical gout at the age of 41,4±3,3 years, with class II-III stable angina, hypertension and sinus rhythm without data suggestive of heart failure was performed. All patients included in the study were randomly divided into two groups: eighteen patients took bisoprolol at a dose of 2,5 to 10 mg/day, 17 subjects received bisoprolol 2,5 mg/day with ivabradine (Coraxan, SERVIER, France) 5 mg 2 times a day. Adjustment of the therapy was carried out every 2 weeks until the target heart rate (HR) was reached at 55-60 beats/min and then remained unchanged until 12 weeks of therapy. All patients underwent echocardiography, 24-hour Holter and central aortic blood pressure monitoring, and 3-minute cycle ergometer test with a power of 25, 50, 75 and 100 watts.Results. There was a comparable decrease in the maximum and minimum 24-hour average heart rates in patients receiving only bisoprolol and those taking bisoprolol+ivabradine. Patients taking bisoprolol+ivabradine had a decrease of central systolic and diastolic blood pressure (BP). Pulse pressure in the bisoprolol group increased by 17,7% (p=0,02), and when ivabradine was added, on the contrary, it decreased by 7,0% (p=0,04). Twelve-week therapy with beta-blockers and ivabradine was accompanied by an effective decrease in the pulse wave velocity in both groups (p<0,05). All gout patients did not have a decrease of systolic function and there was an improvement in diastolic remodeling with beta-blockers and ivabradine therapy.Conclusion. The results obtained indicate that the addition of ivabradine to bisoprolol leads to an effective decrease in heart rate, an improvement in arterial stiffness and exercise tolerance. Combination therapy with ivabradine is accompanied by an improvement in clinical outcomes using lower doses of bet-blockers, which requires further study and a double-blind controlled study

Renal filtration function in patients with gout

Aim. To study circadian blood pressure (BP) profile in patients with gout depending on the presence of arterial hypertension (HT) and their relationship to the renal filtration function.Material and methods. Patients with gout (n=87) were included into the study. All the patients underwent ambulatory BP monitoring (ABPM) with the assessment of circadian BP profile, determination of uric acid serum levels, glomerular filtration rate (GFR) was evaluated by CKD-EPI method. Depending on GFR level, all the patients were divided into 2 groups - with renal dysfunction or without one.Results. ABPM revealed circadian BP dysregulation in 55% of gout patients both with HT and without HT. Chronic kidney disease (CKD) was revealed in 72.4% of male patients, with the prevalence in patients with HT (76.6 vs 61%; p<0.001). Correlations between uric acid levels and some ABPM indicators and GFR were determined.Conclusion. Obtained data suggest the contribution of hyperuricemia in disorders of systemic and renal hemodynamics, leading to the early development of CKD

Renal filtration function in patients with gout

Aim. To study circadian blood pressure (BP) profile in patients with gout depending on the presence of arterial hypertension (HT) and their relationship to the renal filtration function.Material and methods. Patients with gout (n=87) were included into the study. All the patients underwent ambulatory BP monitoring (ABPM) with the assessment of circadian BP profile, determination of uric acid serum levels, glomerular filtration rate (GFR) was evaluated by CKD-EPI method. Depending on GFR level, all the patients were divided into 2 groups - with renal dysfunction or without one.Results. ABPM revealed circadian BP dysregulation in 55% of gout patients both with HT and without HT. Chronic kidney disease (CKD) was revealed in 72.4% of male patients, with the prevalence in patients with HT (76.6 vs 61%; p<0.001). Correlations between uric acid levels and some ABPM indicators and GFR were determined.Conclusion. Obtained data suggest the contribution of hyperuricemia in disorders of systemic and renal hemodynamics, leading to the early development of CKD

Clinical and pathogenetic significance of angiogenesis factors (VEGF-A, HGF, IGF-1) in the development of cardiometabolic disorders in gout patients having different obesity phenotypes

Aim. To study such circulating angiogenesis factors as vascular endothelial growth factor (VEGF-A), hepatocyte growth factor (HGF), insulin-like growth factor (IGF-1), as well as the cytokine profile (IL-1β, TNF-α, IL-6, IL-8, IL-23) and their soluble receptors (SRp55 TNF-α, SR IL-6) in the blood serum of gout patients having various obesity phenotypes.Material and methods. The study included 112 male patients with intercritical gout. The patients were divided into 2 study groups: the 1st group consisted of 39 patients with a metabolically healthy obesity (MHO) phenotype and body mass index (BMI) ≥25 kg/m2; the 2nd group included 73 people having metabolically unhealthy obesity (MUO) with impaired immune status, hypertension (HTN) and class 1 abdominal obesity. The control group consisted of 25 metabolically healthy subjects with normal body weight. Serum concentration of uric acid, CRP, insulin, leptin, insulin resistance index (HOMA-IR), cytokine status, plasma levels of VEGF-A, HGF, IGF-1 were studied. To assess the left ventricular (LV) diastolic function, tissue Doppler imaging of the mitral annulus was used.Results. In the group of patients with MUO, an increase of pro-inflammatory cytokines (IL-1β, IL-6, IL-23, TNF-α, SRp55 TNF-α) was revealed, while the level of TNF-α and IL-1β exceeds the control values in 4,7 and 6,8 times, respectively (p <0,05), and in the group of patients with MHO, 1,4 and 1,6 times, respectively (p<0,05). Correlations between VEGF-A and TNF-α (r=0,59, p<0,0001), IL-6 (r=0,68, p<0,001), CRP (r=0,59, p<0,0001), serum uric acid level (r=0,47, p<0,0001), decrease in high-density lipoprotein cholesterol (HDL-C) (r=-0,28, p<0,05) and diastolic blood pressure (r=0,51, p<0,0001) were determined. The concentration of HGF and VEGF-A correlated with BMI (p<0,001). Associations of IGF-1 and HGF with hyperuricemia, carbohydrate metabolism and diastolic remodeling were established.Conclusion. The relationship between circulating levels of VEGF-A, HGF and IGF-1 with indicators of cytokine status, carbohydrate metabolism and Doppler imaging criteria for LV diastolic dysfunction allows to consider them as additional predictors of unfavorable cardiovascular risk

HE ROLE OF FATTY ACID CONTENTS OF ERYTHROCYTES MEMBRANES IN CARDIOHEMODYNAMICS DISORDER IN GOUT PATIENTS WITH INSULIN RESISTANCE SYNDROME

Aim. To assess the specifics of fatty acidic contents of erythrocyte membranes, and morpho-functional disorder of the left ventricle (LV) in gout patients depending on the syndrome of insulin resistance (IR).Material and methods. In the study, 117 males participated, age 39 to 55 y o., with gout. Among them, 43.6% presented with normal HOMA-IR, and the rest had IR. Fatty acid content of membrane lipids assessed, as the morphofunctional properties of theLV, with the types ofLV geometry and its diastolic function assessment, according to presence or absence of IR.Results. Changes of fatty acid contents in IR and gout patients cells membranes are characterized by increased amount of saturated fatty acids and decreased — of unsaturated, and in the pool of unsaturated acids there is increase of monoenic, but significant decrease of polyenic acids. In the pool of polyunsaturted acids there is increased amount of y-linoleic and dihomo-y-linoleic and significant decrease of arachidonic and docosapentaenoic acids. It is found, that cardiohemodynamics parameters in gout patients do significantly differ with IR. In males with gout and IR the prevailing variant of theLV architectonics was concentric hypertrophy (49,3%; p<0,05). Patients with the normal parameters of glucose-insulin homeostasis more commonly showed normal geometry (26,6%; p<0,05) and eccentric hypetrophy ofLV (46,8%; p<0,05). Diastolic dysfunction of theLV was registered 2,8 times more frequently in the insulin resistant patients. There were correlations found of hyperuricaemia, increased insulin level and changes of fatty acidic content and cardiohemodynamics parameters.Conclusion. The found relations of the fractional contents of fatty acids, morphofunctional disorder of theLV and parameters of carbohydrate metabolism might impact significantly the development of cardiovascular complications in this category of patients

Declension of the possessive names of adjectives taking into account inflexion, complete and short forms

В статье описаны исследования по бионике интеллекта с использованием естественного языка. Предмет исследования – правила склонения притяжательных имен прилагательных, которые записаны с помощью отношений предикатов. По полученным отношениям были построены двудольные графы. При исследовании учитывались полные и краткие формы имен прилагательных притяжательные, а также прилагательные с основой на «й».В статті описано дослідження по біоніці інтелекту з використанням природної мови. Предмет досліджень – правила відмінювання присвійних прикметників, що записані з допомогою відношень. За отриманими відношеннями були побудовані дводольні графи. В дослідженні враховувались повні та короткі форми прикметників, а також присвійних прикметників з основою на «й» в російській мові.In the article it is described research on bionics of intellect with the use of human language. The article of research is rules of declension of the possessive names of adjectives which are written down by the relations of predicates. On the got relations dicotyledonous columns were built. At research the complete and short forms of the names of adjectives were taken into account possessive, and also adjectives with basis on «й»

Chemical Composition and Antibacterial Activity of Essential Oils from Ferula L. Species against Methicillin-Resistant Staphylococcus aureus

Essential oils (EOs) were obtained by hydrodistillation of various parts of Ferula ovina (Boiss.) Boiss., Ferula iliensis Krasn. ex. Korovin, and Ferula akitschkensis B. Fedtsch. ex Koso-Pol., collected in the flowering/budding and fruiting stages. Eight samples of EOs isolated from F. ovina and four samples from F. akitsckensis were analyzed by gas chromatography–mass spectrometry (GC-MS). The major constituents of F. ovina EOs were α-pinene (6.9–47.8%), β-pinene (1.5–7.1%), sabinene (0.1–20.5%), β-phellandrene (0–6.5%), trans-verbenol (0.9–7.4%), eremophilene (3.1–12%), and 6Z-2,5,5,10-tetramethyl-undeca-2,6,9-trien-8-one (0–13.7%). The major constituents of F. akitsckensis EOs were α-pinene (0–46.2%), β-pinene (0–47.9%), sabinene (0–28.3%), eremophilene (0–10.6), β-caryophyllene (0–7.5%), himachalen-7-ol (0–28.2%), and an himachalol derivative (0–8.3%). Samples of EOs from F. ovina, F. iliensis, and F. akitsckensis were evaluated for antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) pulse-field gel electrophoresis type USA300 (LAC). EOs from F. ovina exhibited the highest antibacterial activity compared to samples from other Ferula spp., with the most potent EOs being isolated from roots at the flowering and fruiting stages and stems at the fruiting stage (IC50 values of 19.1, 20.9, and 22.9 µg/mL, respectively). Although EOs demonstrated concentration-dependent inhibition of MRSA growth, analysis of the major constituents (α-pinene, β-pinene, and sabinene) showed that they had low activity, suggesting that other components were likely responsible for the observed bioactivity of the unfractionated EOs. Indeed, correlation of the GC-MS data with antibacterial activity suggested that the putative components responsible for antibacterial activity were, either individually or in combination, eremophilene and trans-verbenol. Overall, these results suggest that the EOs from F. ovina could have potential for use as alternative remedies for the treatment of infectious diseases caused by MRSA