Das Modell der Datentreuhand in der medizinischen Forschung

Der Konflikt zwischen Datenschutz und Forschungsfreiheit ist so alt wie das Datenschutzrecht selbst. In vielen Fällen wird Datenschutz als ein Hemmschuh für die Forschung wahrgenommen, gerade auch im Bereich der medizinischen Forschung. Ein aktuell viel diskutierter Lösungsansatz, diesen Konflikt zu entschärfen, ist das Modell der Datentreuhand. Ob und wie ein solches Modell nutzbar gemacht werden kann, um für die medizinische Forschung einen leichteren und großzügigeren Zugang zu personenbezogenen Daten zu eröffnen, soll im Folgenden erörtert werden

Loss of zinc transporters ZIP1 and ZIP3 augments platelet reactivity in response to thrombin and accelerates thrombus formation in vivo

Zinc (Zn2+) is considered as important mediator of immune cell function, thrombosis and haemostasis. However, our understanding of the transport mechanisms that regulate Zn2+ homeostasis in platelets is limited. Zn2+ transporters, ZIPs and ZnTs, are widely expressed in eukaryotic cells. Using mice globally lacking ZIP1 and ZIP3 (ZIP1/3 DKO), our aim was to explore the potential role of these Zn2+ transporters in maintaining platelet Zn2+ homeostasis and in the regulation of platelet function. While ICP-MS measurements indicated unaltered overall Zn2+ concentrations in platelets of ZIP1/3 DKO mice, we observed a significantly increased content of FluoZin3-stainable free Zn2+, which, however, appears to be released less efficiently upon thrombin-stimulated platelet activation. On the functional level, ZIP1/3 DKO platelets exhibited a hyperactive response towards threshold concentrations of G protein-coupled receptor (GPCR) agonists, while immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptor agonist signalling was unaffected. This resulted in enhanced platelet aggregation towards thrombin, bigger thrombus volume under flow ex vivo and faster in vivo thrombus formation in ZIP1/3 DKO mice. Molecularly, augmented GPCR responses were accompanied by enhanced Ca2+ and PKC, CamKII and ERK1/2 signalling. The current study thereby identifies ZIP1 and ZIP3 as important regulators for the maintenance of platelet Zn2+ homeostasis and function

ELNs in the context of Researcher and Lab Workflows and Institutional Infrastructure

This PDF-file contains the slides presented in Berlin 2016 (ELN Workshop Berlin –14.-15. März 2016

Material presented at EAHIL 2018 (Cardiff, UK) in Session CEC 7 (Electronic Laboratory Notebooks)

For centuries, the research process in biomedicine is documented in paperbased laboratory notebooks. As nowadays more and more data are collected in digital form however, a growing number of researchers is considering the use of electronic laboratory notebooks (ELNs). ELNs offer the chance to foster active research data management, as they facilitate collecting, documenting and sharing data with the corresponding metadata, such as experimental parameters. Therefore, many universities and other research institutions are currently developing support services for ELNs. The aim of this course is to provide participants with basic knowledge on ELNs as an emerging technology. Following a presentation of three different approaches to establish ELN services, participants will explore and discuss possibilities of supporting the use of ELNs at their institution. In addition, there will be the possibility to try different ELNs hands-on

PDF Copy Of Online Survey

This is a PDF copy of an online-survey sent to members of UMG within the GRAcE-project. Link to a copy of the online-survey: Online Survey</a