Labor Costs and the Social Dumping Debate in the European Union

This study examines the labor cost incentive for capital movement in manufacturing within the European Union, a key aspect of the social dumping debate in Western Europe. The authors find that the percentage differences in unit labor costs between the more developed and less developed countries in the Union not only were large in 1980 but actually grew between 1980 and 1986, and separate estimates of compensation and productivity growth rates do not indicate that significant convergence occurred over the remainder of the 1980s. Although these findings apparently confirm that a labor cost incentive for capital mobility does exist, analysis of foreign direct investment data indicates that during the period 1980-88 capital flows to the lower labor cost countries actually were not much larger than capital flows to the higher labor cost countries

Industrial Relations System Transformation

This paper analyzes the concept of “transformation” that many allege has occurred recently in a wide variety of national industrial relations systems. After a summary of the debate, with particular reference to the contentious case of Germany, the authors attempt to develop a definition of industrial relations system transformation on the basis of biological analogies and, in particular, the “punctuated equilibrium” theory. They examine the cases of the United States, Sweden, South Africa, and New Zealand, and conclude that the application of the biological frameworks raises a set of fundamental questions that must be addressed in order for the debate over the existence of industrial relations transformation to move forward

Change and Transformation in Asian Industrial Relations

Authors argue that industrial relations systems change due to shifts in the constraints facing those systems, and that the most salient constraints facing IR systems in Asia have shifted from those of maintaining labor peace and stability in the early stages of industrialization, to those of increasing both numerical and functional flexibility in the 1980s and 1990s. The evidence to sustain the argument is drawn from seven “representative” Asian IR systems: Japan, South Korea, Singapore, Malaysia, the Philippines, India, and China. They also distinguish between systems that have smoothly adapted (Singapore, Malaysia, and the Philippines) and systems that have fundamentally transformed (China and South Korea), and hypothesize about the reasons for this difference

Recent Developments in Employment Relations in the Philippines

We seek to describe recent developments in employment relations in the Philippines, placing these developments in the contexts of the distinctive elements of the Philippine social/political/industrial relations systems as well as the ongoing trade-based and functional integration of international markets and the recent regional economic crisis. We find that, while some firms are pursuing functional flexibility and more cooperative employment relations, the logic of competition has primarily induced firms to adopt practices that promote numerical flexibility such that a core-periphery workforce is created. We argue that the labor movement in the Philippines has been hampered in its efforts to effectively counter employer strategies by its low density, its fragmentation, and an unfavorable public policy environment; Philippine labor unions have, however, made some recent gains in organizing and inter-union coordination. We also argue that governments, both national and regional, have not done enough to counteract the negative effects of market integration on workers nor to evolve the Philippines into a higher value-added exporter

Pembrolizumab for patients with non-Hodgkin lymphoma: Phase 1b KEYNOTE-013 study

The multicohort phase 1b KEYNOTE-013 study (NCT01953692) evaluated the safety and efficacy of pembrolizumab in patients with relapsed or refractory NHL who were ineligible for or failed hematopoietic cell transplantation (HCT). Patients received pembrolizumab (cohort 4) or pembrolizumab plus lenalidomide (cohort 5). Primary end points were safety and objective response rate (ORR) per IWG 2007 criteria. Cohort 4 included 89 patients. ORR was 22% (19/86; 90% CI 15-31; 10 CR, nine PR); ORRs by disease type were 48% (10/21), 10% (2/20), 12% (5/41), and 50% (2/4), for PMBCL, FL, DLBCL, and \u27other\u27 NHL, respectively. Toxicity was as predicted. Cohort 5 included 19 patients. ORR was 39% (90% CI 20-61; four CR, three PR). Hematologic toxicities were the most common treatment-related AEs. In conclusion, pembrolizumab following HCT ineligibility/failure confirms prior experience in PMBCL but not with NHL subtypes in this study. Additional analyses in DLBCL may not be warranted

Vector Algebra in the Analysis of Genome-Wide Expression Data

Background: Data from thousands of transcription-profiling experiments in organisms ranging from yeast to humans are now publicly available. How best to analyze these data remains an important challenge. A variety of tools have been used for this purpose, including hierarchical clustering, self-organizing maps and principal components analysis. In particular, concepts from vector algebra have proven useful in the study of genome-wide expression data. Results: Here we present a framework based on vector algebra for the analysis of transcription profiles that is geometrically intuitive and computationally efficient. Concepts in vector algebra such as angles, magnitudes, subspaces, singular value decomposition, bases and projections have natural and powerful interpretations in the analysis of microarray data. Angles in particular offer a rigorous method of defining 'similarity' and are useful in evaluating the claims of a microarray-based study. We present a sample analysis of cells treated with rapamycin, an immunosuppressant whose effects have been extensively studied with microarrays. In addition, the algebraic concept of a basis for a space affords the opportunity to simplify data analysis and uncover a limited number of expression vectors to span the transcriptional range of cell behavior. Conclusions: This framework represents a compact, powerful and scalable construction for analysis and computation. As the amount of microarray data in the public domain grows, these vector-based methods are relevant in determining statistical significance. These approaches are also well suited to extract biologically meaningful information in the analysis of signaling networks.Chemistry and Chemical Biolog

Immunolocalization of a Drosha-Like Protein in Tetrahymena thermophila

Drosha is an enzyme used by animals to process pri-miRNA into pre-miRNA. This processing normally occurs in the nucleus. The partly processed RNA molecule is then exported to the cytosol, where it is fully processed and then used in gene regulation. While much is known about this process in animals, less is known about how unicellular organisms process miRNA. We wanted to compare miRNA processing in the unicellular eukaryote, Tetrahymena thermophila with miRNA processing in the animal kingdom. In our past studies, we have successfully purified miRNA from Tetrahymena thermophila. Our searches of the Tetrahymena Genome Database indicated the presence of multiple genes with very high levels of homology to the miRNA processing enzymes Drosha and Dicer. Because of these data, we postulated that an anti-Drosha antibody would bind to a number of proteins in Tetrahymena. We hypothesized that a Drosha-like protein would immunolocalize to the nucleus of Tetrahymena, as seen in animal systems