Prevalence of taurodontism in a modern Austrian sample

Taurodontism is a dental condition characterized by an abnormality in the tooth root formation, believed to be caused by defects in the invagination of the Hertwig epithelial sheath during root development. It is characterized by an enlarged, apically displaced pulp chamber, short roots, and a lack of constriction at the enamel-cementum junction. Taurodontism is classified into three degrees: hypo-, meso- and hypertaurodontism. The data was collected by measuring the height of the pulp chamber in relation to the length of the pulp chamber roof to the apex of the longest root in multirooted teeth. In this study, 1,000 panoramic radiographs (PAN) from a dental practice in Upper Austria were evaluated according to the classification of Shifman and Chanannel (1978). Hypotaurodontism was not recorded. Among the subjects evaluated, 5.9% were affected by taurodontism, and the prevalence of taurodontic teeth was 1.4%. It was found that slightly more women than men exhibited the presence of taurodontism. Mesotaurodontism was identified in 43 subjects (4.3%), hypertaurodontism in eight subjects (0.8%), and both forms were present in eight cases (0.8%). The anomaly occurred significantly more frequently in the maxilla than in the mandible. The prevalence of taurodontism varies considerably worldwide due to several factors: the use of different classifications, sample sizes, variable inclusion and exclusion criteria, and population genetic reasons. Clinically, taurodontism complicates procedures such as extractions, endodontic, prosthodontic, periodontal and orthodontic treatments, which underscores its relevance in dental practice

Prevalence of taurodontism in a modern Austrian sample

Taurodontism is a dental condition characterized by an abnormality in the tooth root formation, believed to be caused by defects in the invagination of the Hertwig epithelial sheath during root development. It is characterized by an enlarged, apically displaced pulp chamber, short roots, and a lack of constriction at the enamel-cementum junction. Taurodontism is classified into three degrees: hypo-, meso- and hypertaurodontism. The data was collected by measuring the height of the pulp chamber in relation to the length of the pulp chamber roof to the apex of the longest root in multirooted teeth. In this study, 1,000 panoramic radiographs (PAN) from a dental practice in Upper Austria were evaluated according to the classification of Shifman and Chanannel (1978). Hypotaurodontism was not recorded. Among the subjects evaluated, 5.9% were affected by taurodontism, and the prevalence of taurodontic teeth was 1.4%. It was found that slightly more women than men exhibited the presence of taurodontism. Mesotaurodontism was identified in 43 subjects (4.3%), hypertaurodontism in eight subjects (0.8%), and both forms were present in eight cases (0.8%). The anomaly occurred significantly more frequently in the maxilla than in the mandible. The prevalence of taurodontism varies considerably worldwide due to several factors: the use of different classifications, sample sizes, variable inclusion and exclusion criteria, and population genetic reasons. Clinically, taurodontism complicates procedures such as extractions, endodontic, prosthodontic, periodontal and orthodontic treatments, which underscores its relevance in dental practice

Characterization of a newly identified ETV6-NTRK3 fusion transcript in acute myeloid leukemia

BACKGROUND: Characterization of novel fusion genes in acute leukemia is important for gaining information about leukemia genesis. We describe the characterization of a new ETV6 fusion gene in acute myeloid leukemia (AML) FAB M0 as a result of an uncommon translocation involving chromosomes 12 and 15. METHODS: The ETV6 locus at 12p13 was shown to be translocated and to constitute the 5' end of the fusion product by ETV6 break apart fluorescence in situ hybridisation (FISH). To identify a fusion partner 3' rapid amplification of cDNA-ends with polymerase chain reaction (RACE PCR) was performed followed by cloning and sequencing. RESULTS: The NTRK3 gene on chromosome 15 was found to constitute the 3' end of the fusion gene and the underlying ETV6-NTRK3 rearrangement was verified by reverse transcriptase PCR. No RNA of the reciprocal NTRK3-ETV6 fusion gene could be detected. CONCLUSION: We have characterized a novel ETV6-NTRK3 fusion transcript which has not been previously described in AML FAB M0 by FISH and RACE PCR. ETV6-NTRK3 rearrangements have been described in secretory breast carcinoma and congenital fibrosarcoma

Leistungen des ökologischen Landbaus für Umwelt und Gesellschaft - Kontext, Zielsetzung und Vorgehen

Obwohl die Umweltauswirkungen des ökologischen Landbaus wissenschaftlich und politisch allgemein anerkannt sind, gibt es immer noch unterschiedliche Ansichten, wie der Beitrag des ökologischen Landbaus zur Lösung der Umwelt- und Ressourcenprobleme unserer Zeit bewertet werden kann. Dieser Beitrag beschreibt Hintergrund und Inhalt dieser Debatte und beschreibt den Ansatz zur Analyse des aktuellen Forschungsstandes

Characterization of a newly identified ETV6-NTRK3 fusion transcript in acute myeloid leukemia

Abstract Background Characterization of novel fusion genes in acute leukemia is important for gaining information about leukemia genesis. We describe the characterization of a new ETV6 fusion gene in acute myeloid leukemia (AML) FAB M0 as a result of an uncommon translocation involving chromosomes 12 and 15. Methods The ETV6 locus at 12p13 was shown to be translocated and to constitute the 5' end of the fusion product by ETV6 break apart fluorescence in situ hybridisation (FISH). To identify a fusion partner 3' rapid amplification of cDNA-ends with polymerase chain reaction (RACE PCR) was performed followed by cloning and sequencing. Results The NTRK3 gene on chromosome 15 was found to constitute the 3' end of the fusion gene and the underlying ETV6-NTRK3 rearrangement was verified by reverse transcriptase PCR. No RNA of the reciprocal NTRK3-ETV6 fusion gene could be detected. Conclusion We have characterized a novel ETV6-NTRK3 fusion transcript which has not been previously described in AML FAB M0 by FISH and RACE PCR. ETV6-NTRK3 rearrangements have been described in secretory breast carcinoma and congenital fibrosarcoma.</p

Relation between soil organic matter and yield levels of nonlegume crops in organic and conventional farming systems

The aim of this study was to evaluate the interaction between yield levels of nonleguminous crops and soil organic matter (SOM) under the specific conditions of organic and conventional farming, respectively, and to identify implications for SOM management in arable farming considering the farming system (organic vs. conventional). For that purpose, correlations between yield levels of nonlegume crops and actual SOM level (Corg, Nt, Chwe, Nhwe) as well as SOM-level development were examined including primary data from selected treatments of seven long-term field experiments in Germany and Switzerland. Yield levels of nonlegume crops were positively correlated with SOM levels, but the correlation was significant only under conditions of organic farming, and not with conventional farming treatments. While absolute SOM levels had a positive impact on yield levels of nonlegumes, the yield levels of nonlegumes and SOM-level development over time correlated negatively. Due to an increased demand of N from SOM mineralization, higher yield levels of nonlegumes obviously indicate an increased demand for OM supply to maintain SOM levels. Since this observation is highly significant for farming without mineral-N fertilization but not for farming with such fertilization, we conclude that the demand of SOM-level maintenance or enhancement and thus adequate SOM management is highly relevant for crop production in organic farming both from an agronomical and ecological point of view. Under conventional management, the agronomic relevance of SOM with regard to nutrient supply is much lower than under organic management. However, it has to be considered that we excluded other possible benefits of SOM in our survey that may be highly relevant for conventional farming as well