Concise synthesis of (–)-cotylenol, a 14-3-3 PPI molecular glue

Small molecules that modulate the 14-3-3 protein-protein interaction (PPI) network represent valuable therapeutics and tool com-pounds. However, access has been lost to 14-3-3 PPI molecular glues of the cotylenin class, leading to investigations into practi-cal chemical syntheses. Here we report a concise synthesis of (–)-cotylenol via a 10-step entry into the 5-8-5 cotylenin binding region using a convergent fragment coupling and Claisen-ene cascade

Terahertz Application for Non-Destructive Inspection of Coated Al Electrical Conductive Wires

At present, one of the main inspection methods of electric wires is visual inspection. The development of a novel non-destructive inspection technology is required because of various problems, such as water invasion by the removal of insulators. Since terahertz (THz) waves have high transparency to nonpolar substances such as coatings of conductive wire, electric conductive wires are extremely suitable for THz non-destructive inspection. In this research, in order to investigate the quantitative possibility of detecting the defects on aluminum electric wire, THz wave reflection imaging measurement was performed for artificially disconnected wires. It is shown that quantitative detection is possible for the disconnect status of the aluminum electric wire by using THz waves

Cross-wake force and correlated head-tail instability in beam-beam collisions with a large crossing angle

This paper discusses novel coherent beam-beam instability in collisions with a large crossing angle. The instability appears in the correlated head-tail motion of two colliding beams. A cross-wake force, which is localized at the collision point, is introduced to represent the head-tail correlation between colliding beams. A mode-coupling theory based on this localized cross-wake force enables us to explain the correlated heal-tail instability. The use of a collision scheme with a large crossing angle is becoming popular in the design of electron–positron colliders. An example thereof is the SuperKEKB project, in which a collision with a large crossing angle is performed to boost the luminosity to 0.8×10^{36}  cm^{-2} s^{-1}. Future circular colliders will also be designed with a large crossing angle. Strong-strong simulations, which have shown the first coherent head-tail instability, can limit the performance of proposed future colliders. The mechanism whereby this instability occurs is mode coupling due to the cross-wake force. This instability may affect all collider designs based on the crab waist scheme

キラルシラシクロペンテノールの変換を基盤とするキラルシラシクロペンタン類の立体選択的合成

修士（理学