Arquitetura da Informação Multimodal: contribuições no desenvolvimento de Inteligência Artificial

Resumo Apresentar contribuições da Arquitetura da Informação Multimodal na organização da informação para treinamento de redes neurais artificiais, visando posicionar a Ciência da Informação como área do conhecimento atuante em problemas de Inteligência Artificial. Utilizaram-se as definições da Arquitetura da Informação Multimodal seguindo a fase tecnológica com abordagem explicativa e qualitativa. Propõe-se procedimento de cinco passos para delineamento, análise e transformação do espaço informacional a ser utilizado em métodos de treinamento e aprendizagem de redes neurais, de forma a complementar lacunas identificadas por autores voltados a implementações da ciência da computação. Verifica-se potencial para desenvolvimento de um método estruturado de Arquitetura da Informação Multimodal que forneça instrumentos para a organização do pré-processamento de dados a serem utilizados como massa de teste e aprendizado em redes neurais artificiais. Esse método posicionaria a ciência da informação como atuante e produtora de soluções de inteligência artificial, substituindo o papel atual de mera consumidora de soluções pré-fabricadas pela Ciência da Computação

Tumor Shrinkage in Response to Vitamin K2 in Hepatocellular Carcinoma with Multiple Lung Metastases: A Case Report

Introduction: Advanced or metastatic hepatocellular carcinoma (HCC) can be lethal because of the limited therapeutic approach such as sorafenib. Recently, Vitamin K2 (VK2) has been increasingly recognized to have anti-cancer effects for HCC in vitro and vivo. However, the direct anti-cancer effect of VK2 to HCC has not been established yet in human.Presentation of Case: We presented here a 88-year-HCC patient displayed a tumor shrinkage in response to VK2 in multiple lung metastases, indicating the possibility of VK2 as an anti-cancer agent in human. Menatetrenone, a VK2 analogue, was introduced for multiple lung metastases as a palliative treatment, and thereafter multiple lung metastases, except one lung lesion, displayed tumor shrinkage and disappeared within five months after VK2 intake. The residual one lesion continued to grow up during the intake of VK2, suggesting that the residual tumor was insensitive to VK2 represented by tumor heterogeneity. Consequently, after a radiation therapy for the residual lesion, the elevated tumor markers of all were finally decreased into normal levels, and he is still alive for 18 months after VK2 intake without elevated tumor marker levels and toxic adverse effects.Conclusion:VK2 may be a therapeutic option for advanced and metastatic HCCs without any toxic adverse

Isolation from a Healthy Carrier and Characterization of a Neisseria meningitidis Strain That Is Deficient in γ-Glutamyl Aminopeptidase Activity

γ-Glutamyl aminopeptidase (GGT) activity is used as a specific marker for the identification of Neisseria meningitidis. We isolated from a healthy carrier and characterized an N. meningitidis isolate which lacked the activity due to the insertional mutation of the ggt gene, suggesting that naturally occurring N. meningitidis isolates do not always possess GGT activity

Hand-assisted laparoscopic spleen-preserving distal pancreatectomy combined with laparoscopic distal gastrectomy for the treatment of pancreatic neuroendocrine tumor with early gastric cancer: Report of a case

AbstractIntroductionIn a distal pancreatectomy combined with a distal gastrectomy, the splenic artery and vein must be conserved. However, it is not easy in pure laparoscopic surgery. We performed a hand-assisted laparoscopic spleen-preserving distal pancreatectomy (HALS-SPDP) combined with a laparoscopic distal gastrectomy (LDG) for the treatment of a pancreatic neuroendocrine tumor (NET) with early gastric cancer.Presentation of caseA 67-year-old male was hospitalized with no complaint. He was diagnosed with a pancreatic tail tumor (1.5cm in diameter) and early gastric cancer. He had undergone an endoscopic submucosal dissection (ESD). The pathohistology of the dissected tissue demonstrated that the histology was moderately differentiated adenocarcinoma, and the depth of the gastric cancer was pT1b2 (submucosal layer ∼1000μm). First, a pancreatectomy was performed extracorporeally under direct vision after detaching the spleen and the distal pancreas from the retroperitoneum under a hand-assisted laparoscopy. After the distal pancreatectomy, an LDG with a D1 lymphadenectomy was performed intracorporeally. The postoperative course was not eventful. Six months after surgery, an enhanced computed tomography (CT) scan revealed the patency of the splenic artery.ConclusionAn HALS-SPDP combined with an LDG is beneficial and safe for the patients who have a pancreatic benign or low-grade malignant tumor and gastric cancer