Low-Molecular Weight Cow Colostrum Components in Functional Nutrition

Background: The concept of functional nutrition has been actively developed in recent years. LMWCC contains biologically active compounds of natural origin and can be promising components of functional nutrition.Methods: Wistar rats (intact, rats with Cu-induced toxicosis and rats with Cu-induced toxicosis, who received LMWCC per os in different doses of 0.01, 0.05, 0.1, 1, 2, 3 mg / 100 g of body weight of the animal). The effect of low-molecular weight components of cow colostrum (LMWCC) have been studied on the some physiological and biochemical parameters (body weight, temperature, ability to perform work, activity of aspartate aminotransferase, alanine aminotransferase, cholesterol, triacylglycerides, creatinine, albumin, gamma-glutamyltransferase and lipid hydroperoxides) in experimental animals with Cu -induced toxicosis.Results: It was found that LMWCC in small doses (0.05-0.1 mg / 100 g of weight) restored the growth rate, body temperature and partially working capacity in the test "swimming with a load" of animals with Cu-induced toxicosis. Restoration of physiological parameters in animals with Cu-induced toxemia correlated with activation of the antioxidant enzyme glutathione peroxidase and a decrease in serum hydroperoxides in blood serum.It was suggested that LMWCC can be promising components of functional nutrition for various toxicoses.Conclusions: LMWCC has antioxidant properties in relatively small doses (0.05-0.1 mg / 100 g of weight). Restoration of the physiological characteristics of animals with Cu-induced toxicosis correlates with the elimination of oxidative stress. Large doses of 1 mg / 100 g of body weight and more manifest pro-oxidant properties

The Toxic Effects of Low Molecular Weight Components of Cow Colostrums: The Short-Term and Long-Term Effects

Abstract: Background: Low-molecular components of colostrum (LMWCC) have a pronounced biological activity. We investigated the effect of different doses of LMWCC (0.01, 0.1, 1 and 5 g/100 g of body weight) on the behavior, dynamics of growth, acute and chronic toxicity, as well as the relative weight of the liver, spleen and kidneys of the experimental animals. Methods: We used 100 3-month male rats in the experiment. All animals were divided into 5 groups of 20 animals in each group, LMWCC was administered per os, and the control group received sterile water. Results: LMWCC revealed no pirogenic effect in a wide diapason of doses (0,01-5 g/100 g of animal mass). Immediately after the LMWCC administration the short-time decrease in the motion activity was observed. The low doses of LMWCC induced diarrhea in 10-20 % of of animals, the super-large dose – in 75% of animals. The acute toxicity of LMWCC (death of 15 % of animals) was detected only in super-large dose of LMWCC and it was accompanied by pronounced diarrhea. LMWCC influenced the mass of liver, spleen and kidney. 60 days after LMWCC administration the mass of liver was restored to control weight, but the mass of spleen and kidney was not restored. Conclusion: LMWCCdo not have chronic toxicity and can be attributed to non-toxic compounds with a possible side effect - a violation of the digestive system