A CLINICAL STUDY TO COMPARE THE EFFECT OF LEKHNIYA MAHAKASHAY THROUGH ORAL ADMINISTRATION AND SARWANG SWEDAN IN CASES OF STHAULYA W.S.R TO OBESITY

Today 2.1billion people nearly 30% of world population are either obese or overweight. The rise in global obesity rates over the last 3 decades has been wide spread presenting a major public health epidemic both for the developed and developing world. In Ayurveda obesity is referred as Sthaulya. Excessive truncal adiposity is very well correlated with risk for diabetes, hypertension and cardiovascular disease obese people are 20% more likely to develop pancreatic cancer, number of GI disorder and hepatobiliary disorder. Mostly obesity is primary i.e., no obvious cause exists other than imbalance in energy intake and energy expenditure. Importantly modest losses of 5% to 10% of body weight have been shown to reduce health risk such as hyperlipidemia, hypertension and insulin resistance. In this research drugs are selected from Ayurvedic classics and the effect of Lekhaniya mahakashay is compared in Sarwang swedan as well as in oral medication. Overall goals of this weight loss management are, to prevent further weight gain, to lose weight to achieve a realistic target BMI and to maintain a lower body weight over the long term

Recurrent Sequences and Cryptography

Fibonacci numbers are defined as recursively as F_(n+1)=F_n+F_(n-1) with initial conditions F_1=F_2=1. Lucas numbers also enjoys the same recurrence relation but with different initial conditions L_1=1,L_2=3. Large prims are very useful in public key cryptography. Lucas numbers can also be exploited for these purpose

Antenatal screening for thalassemia carrier at tertiary care centre

Background: Thalassemia syndromes are the commonest genetic disorders of blood and constitute a vast public health problem with 2.78 to 4% prevalence in India. The most effective and feasible approach to reduce the incidence of thalassemia major is implementation of carrier screening program to screen the antenatal women in early pregnancy. Methods: Institutional based cross sectional observational study was conducted. We screened 400 antenatal women by performing preliminary test red cell indices, Mentzer index and confirmatory test by high performance liquid chromatography. Husbands of positive women were also tested to find out couples on risk. Results: Out of 400 antenatal women screened, 46 required HbA2 estimation, and 11 (2.8%) were diagnosed as β-thalassemia minor positive. Most of thalassemia minor positive women were primigravida and mean (SD) age and gestational age of these women was 23.8 (3.1) years and 11.8 (1.7) weeks, respectively. Amongst thalassemia minor positive women most were mild to moderately anemic and these women had significantly greater mean TRBC count. Ninety one percent of thalassemia minor positive women had MCV<77. All of thalassemia minor positive women had MCH<27. Eighty two percent of thalassemia minor positive women had MI<13. None of couple at-risk was detected. So, prevalence of thalassemia carrier was 2.8%. Conclusions: Thalassemia is a monogenetic disorder with autosomal recessive streak. Universal screening in antenatal window by complete blood counts, hematological indices (MCV, MCH, TRBC), Mentzer index and HPLC may lead to non-pyrrhic victory over this odious entity

A Comparative Study on Apiculture Technology among Trained and Untrained Women

The present study aimed to assess the ‘level of skill’ of rural women about scientific apiculture practices and to find the relationship of different characteristics of women with their level of apiculture practice skill. Total 100 respondents were selected from Pusa block of Samastipur district. Seven villages were selected purposively in which 50 trained who have received training from Apicultural Research Training Centre , RAU Pusa to serve as experimental group and equal number of untrained women who have not undergone any skill oriented apiculture training programme were also selected randomly to serve as control group. The study indicated that the trained women differed significantly over the untrained women in respect of their improvement in skill. The proportion of trained women was more in ‘high level of skill’ of improved apiculture practices in comparision to the untrained women. Multiple regression analysis revealed that three characteristics i.e. caste family education and economic motivation contributed positively and significantly towards improvement in level of skill of recommended technologies among trained women. Hence, it can be said that training has positive impact on apiculture practices of women beekeepers. DOI: 10.17762/ijritcc2321-8169.15012

Study of onychomycosis

Background: Onychomycosis is one of the most common fungal nail infections caused by Dermatophytes, Non-Dermatophytic Molds (NDM) and Yeast. Though it is not life-threatening, can cause pain, discomfort, and disfigurement. It decreases the nail growth rate. Objectives: This study was carried out to document the clinico-mycological pattern and antifungal susceptibility pattern of onychomycosis.Methods: The study group included 130 consecutive patients with suspected fungal nail infections, attending Dermatology outpatient department of King George Hospital, Visakhapatnam, Andhra Pradesh during November 2012 to August 2014. The nail clippings of the patients were collected and subjected to KOH mounts for direct microscopy and fungal culture and antifungal susceptibility tests.Results: Onychomycosis was common among males (66.92%) than females (33.08%) with highest incidence was in age group 31-40 years (41.37%). Finger or toenails were exclusively involved in 32.18% and 55.18% patients respectively while these were involved concurrently in the rest of the 12.65% patients. Distal and lateral subungual onychomycosis seen in 64.36% of the patients was the most common clinical type. KOH and culture positivity were recorded in 56.92% and 48.46% cases respectively. Dermatophytes (50.58%) were predominant isolate followed by NDM (27.58%) and yeast (21.84%). Clotrimazole and ketoconazole were most effective antifungals against dermatophytes. For NDM, itraconazole, nystatin and amphotericin B and for yeast fluconazole and itraconazole were effective.Conclusions: The present study gives an insight about the aetiological agents causing onychomycosis and their anti-fungal susceptibility pattern in this region. Thus, it can help in taking adequate control measures to prevent it

Correlation between value of Hba1c and degree of sensorineural hearing loss in type 2 diabetics

Background: Diabetes mellitus and hearing loss are common public health problems. Sensorineural hearing loss in Type 2 diabetes mellitus patients is an underestimated complication. The aim was to study the correlation between level of HbA1c and degree of sensorineural hearing loss. Methods: It was a cross sectional study carried on 130 known cases of T2DM, aged 25-50 years. Various confounding factors such as coexisting hypertension, ear disease, ototoxic drug intake, any neuropathic disorder was excluded in advance. All patients underwent clinical ear examination and pure tone audiometry test. Their level of HbA1c was measured. This value of HbA1c was correlated with the hearing threshold. Results: Out of 130, 58 subjects had normal hearing while 72 had hearing impairment. Among subjects (72 out of 130) having hearing impairment, significant correlation (p-value 0.035 for right ear and 0.029 for left ear) between hearing threshold and HbA1c was found. Also, level of HbA1c significantly (p-value 0.049) correlated with degree of hearing loss. Conclusions: Hearing loss is an underestimated complication of T2DM. This needs to be addressed with periodic hearing assessment of diabetes patients

Compositional and shelf-life analysis of developed instant Indian recipe chilla mix from hull-less barley: A convenience food product

Barley has a rich nutritional and therapeutic profile. In an era of life-style based silent pandemics, the need to bring on table the convenient food products with sensory and nutritional acceptability is necessary. Hence, the present study aimed to develop an instant chilla mix from a novel hull-less variety of barley (Hordeum vulgare) (PL891). Various random combinations of composite flour (barley flour (BF), rice flour (RF) and gram flour (GF)) were prepared namely T1 (100:00:00), T2 (70:15:15), T3 (60:30:10), T4 (33:33:33), and T5 (00:00:100). Other ingredients such as onion, tomato, ginger, garlic, coriander, and chilli were also added. Nutritional and sensory parameters at fresh, three, six and nine month of storage interval were also analyzed. The assessed parameters (%) were reported as moisture (6.91±0.02 to 10.21±0.09), ash (2.11±0.05 to 3.10±0.02), protein (7.59±0.05 to 24.50±0.06), fat (1.50±0.02 to 6.10±0.04), crude fiber (1.08±0.02 to 2.87±0.02), and total carbohydrates (58.21±0.10 to 75.27±0.07). All the blends varied significantly (p≥0.05) during storage in terms of moisture, protein, fat, crude fiber, and carbohydrates, while a non-significant difference was noted in ash for all the treatments. Blending also affected the nutrient content of all the treatments significantly (P ≤ 0.05) depending upon the ratio of blending and composition of various ingredients in the product. The sensory attributes indicated that T2 blend with 70% PL891 hull-less barley flour was most acceptable. The developed product will be a nutritious substitute for chapati as barley is rich in numerous nutrients and have therapeutic potentials.  

Successful medical management of uterine arteriovenous malformation

Uterine Arteriovenous malformation (AVM) is defined as abnormal communication between the uterine arteries and veins. This can be congenital or acquired. It occurs more frequently in reproductive age group women. Patient present with complain of spotting per vagina to catastrophic bleeding per vaginum. Diagnosis is based upon clinical history and findings in colour doppler of pelvis. The treatment depends upon the age of the patient, her symptoms, age, desire of future fertility and localization and size of the lesion. Uterine artery embolization is the most commonly used treatment for symptomatic uterine arteriovenous malformation. There were few case reports of successful medical management of uterine AVM with GnRH agonist. But GnRH agonist have side effects that restrict its long time use and for Uterine artery embolization, clinical skill and set up is required and it is not available at every hospital. Here is presenting a case report of successful medical management of uterine arteriovenous malformation with combined oral contraceptive pills (coc). COC are easily available everywhere and its side effects are few if compared with GnRH agonist

Producing Copper Powder from Copper Bleed Solution by Hydrogen Reduction

This paper deals with the bench scale investigation on the hydrogen reduction of a highly acidic copper bleed solution.(CBS), generated in an Indian copper smelter, to produce highly pure copper powder. A titanium-lined autoclave of 1 L capacity was used for this study. After the optimization of the parameters for the recovery of copper powder, hydrogen reduction of copper was done in a larger autoclave to validate the results

Prevalence of metallo-beta-lactamases (MBLS) producing Pseudomonas aeruginosa in hospitalized patients in rural tertiary care hospital in Uttar Pradesh, India

Background: Pseudomonas aeruginosa is a leading cause of nosocomial infections due to MBLs production with limited therapeutic options, higher rate of colonization is encountered in hospitalized patient streated with broad spectrum antibiotics. This study was conducted with an aim to know the prevalence of Carbapenem resistant MBLs producing strains of Pseudomonas aeruginosa in hospitalized patients.Methods: A total of 14700 samples were obtained from various wards during Jan 2016 to June 2017, were screened for P. aeruginosa by conventional culture and biochemical tests. All confirmed P. aeruginosa isolates were further subjected to Modified Kirby- Bauer disc diffusion test as per CLSI guidelines. All IPM resistant isolates were screened for MBL production by DDST, CDST, MHT and E-test MBL.Results: Atotal of 1423were identified as P. aeruginosa. The isolation rate of P. aeruginosa at our hospital was 9.7%. Among these, 130(9.1%) isolates were IPM resistant. A total of 111 (85.4%) were MBL positive by CDST and E-test, 92 (70.5%) by DDST and 80 (61.5%) by MHT. The prevalence of MBL producing P. aeruginosa was 111/1423(7.8%) while among IPM resistant P. aeruginosa, its prevalence was 111/130 (85.4%).Conclusions: The study documents presence of nosocomial MBL producing P. aeruginosa strains in our Institute. E-test and CDST were superior to DDST and MHT for detection of MBLs