Spin polarisabilities of the nucleon at NLO in the chiral expansion

We present a calculation of the fourth-order (NLO) contribution to spin-dependent Compton scattering in heavy-baryon chiral perturbation theory, and we give results for the four spin polarisabilities. No low-energy constants, except for the anomalous magnetic moments of the nucleon, enter at this order. For forward scattering the fourth-order piece of the spin polarisability of the proton turns out to be almost twice the size of the leading piece, with the opposite sign. This leads to the conclusion that no prediction can currently be made for this quantity. For backward scattering the fourth-order contribution is much smaller than the third-order piece which is dominated by the anomalous scattering, and so cannot explain the discrepancy between the CPT result and the current best experimental determination.Comment: 8 pages, 2 figures, revtex. Minor typos corrected and reference adde

OPTIMIZATION AND SOLUBILIZATION STUDY OF NANOEMULSION BUDESONIDE AND CONSTRUCTING PSEUDOTERNARY PHASE DIAGRAM

Objective: The aim of the present study was to formulate and optimize budesonide nanoemulsions for targeting inflammation.Methods: Budesonide is only found in individuals that have used or taken this drug. It is a glucocorticoid used in the management of asthma, the treatment of various skin disorders, and allergic rhinitis. The exact mechanism of the action of budesonide in the treatment of Crohn's disease is not fully understood. However, being a glucocorticosteroid, budesonide has a high local anti-inflammatory effect. The formulation was optimized for different components and the solubility study for the oil in surfactant and cosurfactant mix ratio was optimized using ternary phase diagram.Results: The surfactant mix ratio was optimized as 1:3 where the maximum concentration of the oil has solubilized and the nanoemulsion area was increased.Conclusion: Budesonide nanoemulsion for targeting inflammation and the pseudoternary phase diagram for the solubility studies and the components of different phases were optimized and achieved through this study

DEVELOPMENT OF A PERFORMANCE MONITORING SYSTEM TO OPTIMIZE PV BASED SOLAR ELECTRICITY GENERATION

Demand for electricity in Malaysia has seen a substantial hike in light of the nation’s rapid economic development in pursuit of achieving Vision 2020. The current method of generating electricity is through the use of conventional energy sources such as fossil fuels. However, consistent usage of fossil fuels has resulted in detrimental effects towards the environment besides the dampening amount of natural resources available globally. An alternative energy source that is capable of sustaining the demand is needed to ensure a sustainable future. Since its implementation through the Sustainable Energy Development Authority (SEDA), the Feed-in-Tariff (FiT) mechanism has established a total installed Photovoltaic (PV) capacity of 192 MW from 655 projects that are currently operational from the overall of 2628 approved projects in Malaysia

Catheter Direct Thrombolysis as a Modality of Management for Pulmonary Embolism: Risk Stratifying with the Pulmonary Embolism Severity Index

Catheter Directed Thrombolysis (CDT) or Systemic Thrombolysis (ST) are current standards of care for patients experiencing a Massive (MPE) or Submassive (SPE) Pulmonary Embolism which are categories that are defined by AHA guidelines for the Emergency Department. The Pulmonary Embolism Severity Index (PESI), a five-tier system, is a composite metric that can risk stratify PE into low risk (tiers 1,2) for SPE and high risk (tiers 3,4,5) for MPE, predicting mortality and outcomes. This study aims to determine if CDT or ST/no intervention (ST/NI) has better outcomes for MPE and SPE patients, while using PESI as a risk stratification tool. We conducted a retrospective analysis of patients from 2010 – 2016 who underwent CDT or ST/NI, matching patients using ten variables to yield N= 336: with equal proportions receiving CDT and ST/NI. 96 patients were in the low risk PESI group and 240 patients were in the high risk PESI group. In both low and high risk PESI groups, CDT intervention was associated with longer length of stay, (

Inhibition of free radical activity by dual PPAR α and PPAR γ agonist using analytical assay methods

Background: Overproduction of free radicals involved in the pathology of a wide variety of clinical disorders. Poor glycaemic control in diabetic people leads to free radical production responsible for diabetic related complications. Antioxidants produces resistance against the oxidative stress by scavenging free radicals may useful in treating diabetic related complications. Saroglitazar is a newer antidiabetic drug act on dual Peroxisome Proliferator Receptor Agonist α (PPAR α) and PPAR γ agonist with protection effect on Diabetes mellitus induced lipid dystrophy. Our study was done to evaluate the in vitro antioxidant effect Saroglitazar by 1, 1 Diphenyl 2 Picryl hydrazide (DPPH) and Nitric Oxide (NO) method.Methods: In this study, we demonstrated invitro antioxidant activity by using 10 mg/dl stock solutions of Saroglitazar. DPPH and NO free radical scavenging test were done for different concentration of Saroglitazar.Results: Saroglitazar showed concentration dependent free radical scavenging activity in DPPH assay. In DPPH assay at higher concentration 1000ug concentration showed 49.18% free radical scavenging activity. At lower concentration 10ug showed 17.18% free radical scavenging activity. NO scavenging activity at lower concentration 100ug showed 55.15% activity. But the higher concentration (1000ug) only slight increase in 60.15% activity.Conclusions: Thus Saroglitazar invitro antioxidant analysis proved that it is a potent antioxidant

Stability indicating RP-HPLC method development and validation for the simultaneous estimation of Grazoprevir and Elbasvir in bulk and pharmaceutical dosage form

A simple, Accurate and precise method was developed for the simultaneous estimation of the Grazoprevir and Elbasvir in Tablet dosage form. Chromatogram was run through Kromosil C18 (250 x 4.6 mm), 5m. Mobile phase containing Buffer: Acetonitrile taken in the ratio 45:55 was pumped through column at a flow rate of 1 ml/min. Buffer used in this method was Di Potassium Hydrogen ortho Phosphate. Temperature was maintained at 30°C. Optimized wavelength selected was 215 nm. Retention time of Elbasvir and Grazoprevir and were found to be 2.503 min and 3.004. %RSD of the Elbasvir and Grazoprevir were and found to be 0.3 and 0.4 respectively. %Recovery was obtained as 98.17% and 99.83% for Grazoprevir and Elbasvir respectively. LOD, LOQ values obtained from regression equations of Grazoprevir and Elbasvir were 0.24, 0.73 and 0.06, 0.19 respectively. Retention times were decreased and run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries