TRIBAL PLANTS AND THEIR INBORN ANTIMICROBIAL ACTIVITIES

The importance of medicinal plants in traditional health-care practices provides clues to new areas of research and in the biodiversity of conservation. Right from the beginning, the documentation of traditional knowledge, especially on the medicinal uses of plants, has provided many important drugs for the modern day. Even today, this area holds much more hidden treasure as almost 80% of the human population in developing countries depend on plant resources for health care. Keeping this in view, the present study was initiated to document the traditionally used tribal plants and their inborn antimicrobial activity which is enhanced on the synthesis of noble metal nanoparticles

In vitro anticancer activity of Sargassum sp. polysaccharides against MCF-7 cell lines

1267-1273Seaweed polysaccharides are compounds with promising chemopreventive and chemotherapeutic activities. In this study, polysaccharides isolated from Sargassum seaweeds were tested for their efficiency in cancer therapy. Polysaccharides were isolated, purified, and characterized using nuclear magnetic resonance (NMR); and Fourier transform infrared (FT-IR) spectroscopic and matrix-assisted laser desorption ionization mass spectrometric (MALDI-MS). It was found that the polysaccharides from Sargassum sp. branches are sulfated galactose–fucose disaccharides and sulfated galactose monosaccharides attached to the main chain through (1–4) linkages. Further, the polysaccharides were tested for cytotoxicity and anticancer activity against human breast adenocarcinoma cell line (MCF-7) using the Annexin-V/propidium iodide (PI) staining method

Thermal comfort properties of knitted fabrics produced from bamboo/polyester core-spun yarns

The influence of polyester content, twist and loop length on the comfort properties of single jersey knitted fabrics produced from 100% bamboo, 80:20 bamboo/polyester and 60:40 bamboo/polyester core-spun yarns has been studied. Comfort properties, such as air permeability, moisture vapour transmission, thermal conductivity and thermal resistance properties have been analyzed with three different twist levels and loop lengths. Box–Behnken, a three level three factorial design software, has been used to study the interactive effect of core-sheath ratio, twist and loop length on the comfort properties of single jersey knitted fabrics, response surface equations are derived and the design variables are optimized. It is found that the increase in bamboo content in the core yarns having high twist and loop length increases the moisture vapour transmission and thermal conductivity of the knitted fabrics. The air permeability and thermal resistance of the knitted fabrics are found to be higher as the polyester component is increased. High twist and loop length increase the thermal comfort properties of knitted fabrics

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Evaluation and studies on the structural impact of substituted 4, 5-Dihydroisoxazoles on their biological activities

In present study, a series of isoxazole derivatives synthesized were evaluated for antimicrobial activities by disc diffusion method. Some compounds of the series exhibited promising antibacterial and antifungal activity compared to standard drugs. The minimum inhibitory concentration (MIC’s) was determined against each organism. The compounds were tested for their in-vitro antioxidant activity and reducing power ability. Free radicals play an important role in various pathological and xenotoxic effects so antioxidant may have protective role in these pathological conditions. Based on the results of an antimicrobial, anti-oxidant study, the effect of substitution on the activity and possible structure activity relationship of the compounds for their antioxidant activity is presented

Synthetic strategies and significance of pyrroline analogs

The isomeric forms of pyrrolines; 1-pyrroline, 2-pyrroline and 3-pyrroline and their derivatives are an important class of heterocyclic compounds. They exhibit wide range of biological applications, particularly in their versatile enzymatic activity. This brief review article presents up to date information about the strategies adopted for the synthesis of pyrrolines and their derivatives. Also describes the biological activities associated with them, more emphasis was given on their enzymatic activity and impact of these molecules on diseases in plants and animals

Wdrożenie narzędzi „Lean Management” w przemyśle odzieżowym

Garment Manufacturing is one of the oldest in the world, compromising a high number of critical operations. The main issues in the garment industry are the lead time, production rate, very poor line balancing and fabric wastes. Productivity improvement is carried out by implementing the various lean tools in the industry, such as 5S, Value Stream Mapping (VSM) and line balancing in the sewing section. After the implementation of lean tools in the garment industry, the outcomes observed are a reduction in work-in-progress inventory, increases in the production process and increased line efficiency. Similarly the before and after implementation of 5S, which shows space utilisation in the sewing section, is increased. In this research, an implementation study was conducted in only one organisation. Hence the results extracted by the conduct of this implementation study are achievable and adaptable in similar organisations.Główne problemy w przemyśle odzieżowym to czas realizacji, tempo produkcji, bardzo niska równowaga linii i marnotrawstwo tkanin. Celem pracy było uzyskanie poprawy produktywności poprzez wdrożenie różnych narzędzi „Lean Management” w branży, takich jak 5S, Mapowanie Strumienia Wartości (VSM) i równoważenie linii w dziale szycia. Po wdrożeniu narzędzi „Lean Management” w przemyśle odzieżowym na podstawie uzyskanych rezultatów zaobserwowano zmniejszenie zapasów w toku prac, zwiększenie procesu produkcji i zwiększenie wydajności linii. Przedstawione w pracy wyniki dotyczą badania wdrożeniowego przeprowadzonego w jednej organizacji. W związku z tym wyniki uzyskane w ramach tego badania są możliwe do osiągnięcia i dostosowania w podobnych organizacjach

<span style="font-size:14.0pt;line-height: 115%;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:black;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">Study of ionic conductivity in KBr: (CrO₄)^2- crystals</span>

862-866The ionic conductivity of pure KBr and KBr crystals doped with chromate anion has been measured in the temperature range of 200-600oC. In pure KBr crystals, large contribution to conductivity by cation vacancies has been observed at higher temperatures. Ionic conductivity measurements are made on pure KBr crystals and KBr crystals doped with 0.25, 0.5 and 0.75 mole % of chromate anion in as-grown state. Further, the effects of quenching and annealing on conductivity of KBr crystals doped with 0.75 mole % chromate ion are measured. The conductivity versus temperature plots show that, as concentration of impurity anions increases, the conductivity decreases in extrinsic associated region. As the concentration increases to 0.75 mole %, the conductivity increased to high value compared to 0.5 mole %. But, it is less than that of pure crystals. The extrinsic un-associated region shows a slight variation in conductivity but, tends to be same that of as-grown pure KBr crystals. The variation in conductivity of doped KBr crystals are explained on the basis of formation of complexes with background impurities, formation of neutral pairs, introduction of fresh dislocations, etc. The variation in conductivity due to quenching and annealing is explained on the basis of dissociations and aggregation of complexes, vanishing of newly introduced dislocations, etc. The corresponding activation energy values are evaluated.</span