Systems and methods for stable haptic feedback over packet-switched networks

Providing haptic feedback to a user over a packet-switched network includes sensing movement of a haptic device by a user, the haptic device being configured to control a first virtual object within a virtual environment, transmitting data associated with the movement of the haptic device from a client computer to a remote server via the packet-switched network, the server modeling movement of the first virtual object in the virtual environment and estimating an orientation and a position of the first virtual object within the virtual environment, the server determining a type of tactile feedback to be provided to the user, the server transmitting the type of tactile feedback data to the client computer via the packet-switched network, and providing tactile feedback to the user with the haptic device

A phase I clinical study to assess safety and immunogenicity of yellow fever vaccine

Abstract Yellow fever, a mosquito-borne flavivirus infection, is an important public health problem in Africa and Latin America. A Yellow Fever vaccine (YFV) was developed and tested in a study in India. This was a Phase I, open-label, randomized, controlled study where healthy adults received SII YFV intramuscularly (SII YFV IM), SII YFV subcutaneously (SII YFV SC) or STAMARIL® (Sanofi-Pasteur) in 1:1:1 ratio. They were followed for solicited reactions for 10 days and unsolicited events for 28 days and serious adverse events for 3 months. YF-neutralizing antibodies were measured at baseline and on Days 10, 14, 28. A total of 60 adults were enrolled in the study. The proportion of participants with solicited reactions was 10%, 40%, and 25% in SII YFV SC, SII YFV IM, and STAMARIL® arms, respectively. No causally related unsolicited events or any serious adverse event was reported. After vaccination, the seroconversion was 94.44%, 100%, and 100%, in the three arms respectively. The post-vaccination geometric mean titers were similar in the study arms. The new YFV was found safe and immunogenic by IM as well as SC routes. The vaccine can be tested in further phases of clinical studies