The role of apical support and rectal mucosal prolapse excision in successful treatment of rectocele combined with perineum descending: short-term and follow-up results

The aim of the research was to improve the results of surgery treatment of posterior compartment of pelvic floor using abdominal sacrocolpopexy and stapled trance-anal resection (STARR

The advantages of the abdominal sacral colpopexy combined with stapled trance-anal resection of the rectal mucosal prolapse (STARR) for the surgical treament of perineum descending syndrome

The problem of pelvic organ prolapse in women is still actual, because of high frequency of this pathology. Several surgical techniques have been suggested for pelvic descending syndrome treatment. But a large number of complications, unsatisfactory anatomical and functional results of suggested methods force to look for other solutions of the proble

The role of polymorphism of hereditary thrombophilia candidate genes in the development of arterial hypertension in women with preeclampsia

Preeclampsia is a severe pregnancy complication that has long been one of the leading causes of maternal and perinatal mortality and morbidity worldwide. Despite the achievements of modern medicine, the etiology of this pathology is not known. Multiple risk factors for the development of PE have been identified: arterial hypertension, diabetes mellitus, obesity, a hereditary history of preeclampsia, thrombophilia, etc., but recently, special attention has been paid to genetic determinants, namely, the contribution of individual polymorphic loci of various gene

Insilico test of functional role of rs8068318 polymorphism of arterial hypertension-associated TBX2 candidate gene

In the course of this study, the functional role of rs8068318 polymorphism of the TBX2 candidate gene associated with the development of arterial hypertension was studied. The selection of the polymorphic locus was based on the data of the catalog of genome-wide association study (GWAS) of the National Human Genome Research Institute. The functional role was evaluated using online software: HaploReg (v4.1), GTExportal, and PolyPhen-

Endoscopic surgical interventions in the treatment of periampullary cancer

In this paper retrospective treatment result analysis of 386 patients with periampullary cancer, complications are carried out by obstructive jaundice. Patients were organized into two groups: the first group patients to whom traditional surgical interventions were applied, and entered the second – treated with endoscopic transpapillary surgeries. We have shown that at the nonresectable cancer of bodies of a pancreatoduodenal zone complicated by obstructive jaundice, endoscopic transpapillary interventions are the main method of decompression of a biliary tree, thus allowing complete avoidance of traditional surgical intervention

The study of the associations of polymorphism of matrix metalloproteinases with multifactorial human diseases and in silico assessment of their functional effects

The objective of this study is to identify the associations of polymorphism of matrix metalloproteinase genes with multifactorial diseases and evaluate in silico their functional effects. The material for the study was genomic DNA isolated from venous blood samples by the standard phenol-chloroform extraction method. The rs2250889 MMP9, rs11568818 MMP7 and rs17576 MMP9 polymorphic loci were studied using the polymerase chain reaction on a CFX-96 Real-Time System thermal cycler (Bio-Rad Laboratories, Inc., US) using oligonucleotide primers and probes synthesized by Syntol LLC, Russia

Comparative analysis of tissue reactions during implantation of endoprostheses made of polytetrafluoroethylene in the anterior abdominal wall

The objective of this research was a comparative study of the reaction of the tissues of the anterior abdominal wall to the PTFE-endoprosthesis with a DLC-coating at long-term experimental stage

The OSACA Database and a Kinematic Analysis of Stars in the Solar Neighborhood

We transformed radial velocities compiled from more than 1400 published sources, including the Geneva--Copenhagen survey of the solar neighborhood (CORAVEL-CfA), into a uniform system based on the radial velocities of 854 standard stars in our list. This enabled us to calculate the average weighted radial velocities for more than 25~000 HIPPARCOS stars located in the local Galactic spiral arm (Orion arm) with a median error of +-1 km/s. We use these radial velocities together with the stars' coordinates, parallaxes, and proper motions to determine their Galactic coordinates and space velocities. These quantities, along with other parameters of the stars, are available from the continuously updated Orion Spiral Arm CAtalogue (OSACA) and the associated database. We perform a kinematic analysis of the stars by applying an Ogorodnikov-Milne model to the OSACA data. The kinematics of the nearest single and multiple main-sequence stars differ substantially. We used distant (r\approx 0.2 kpc) stars of mixed spectral composition to estimate the angular velocity of the Galactic rotation -25.7+-1.2 km/s/kpc, and the vertex deviation,l=13+-2 degrees, and detect a negative K effect. This negative K effect is most conspicuous in the motion of A0-A5 giants, and is equal to K=-13.1+-2.0 km/s/kpc.Comment: 16 pages, 8 figure

Malat1 RNA genetic factor and T1 bladder cancer

In this study, we collected overview data regarding the possible association of rs 3200401 polymorphism of the MALAT1 gene in patients with a single focus and multifocal bladder cancer stage T

Could the results of posterior colporrhaphy and levatoroplasty be improved by abdominal sacrocolporectopexy?

The aim of our study was to improve poor results of preliminary colporrhaphy and anterior levatoroplasty performed for patients with low and middle rectocel