44 research outputs found

    The effect of sevelamer carbonate and lanthanum carbonate on the pharmacokinetics of oral calcitriol

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    Background. Lanthanum carbonate and sevelamer carbonate are non-calcium-based phosphate binders used to manage hyperphosphataemia in patients with chronic kidney disease (CKD). Patients with CKD may require intravenous or oral active vitamin D. We investigated the effects of lanthanum carbonate and sevelamer carbonate on the bioavailability of oral calcitriol

    Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms: what do we know and what do we need to know?

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    BACKGROUND: Low vitamin D status is associated with risk of colorectal cancer and has been implicated in inflammatory bowel disease. Irritable bowel syndrome (IBS) is a chronic, relapsing, functional bowel disorder. A nascent literature suggests a role for vitamin D in IBS, but this has not been collated or critiqued. To date, seven studies have been published: four observational studies and three randomised controlled trials (RCTs). All observational studies reported that a substantial proportion of the IBS population was vitamin D deficient. Two intervention studies reported improvement in IBS symptom severity scores and quality of life (QoL) with vitamin D supplementation. There are limited data around the role of vitamin D in IBS. CONCLUSIONS: The available evidence suggests that low vitamin D status is common among the IBS population and merits assessment and rectification for general health reasons alone. An inverse correlation between serum vitamin D and IBS symptom severity is suggested and vitamin D interventions may benefit symptoms. However, the available RCTs do not provide strong, generalisable evidence; larger and adequately powered interventions are needed to establish a case for therapeutic application of vitamin D in IBS

    Processing of Ice Cloud In-Situ Data Collected by Bulk Water, Scattering, and Imaging Probes: Fundamentals, Uncertainties and Efforts towards Consistency

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    In-situ observations of cloud properties made by airborne probes play a critical role in ice cloud research through their role in process studies, parameterization development, and evaluation of simulations and remote sensing retrievals. To determine how cloud properties vary with environmental conditions, in-situ data collected during different field projects processed by different groups must be used. However, due to the diverse algorithms and codes that are used to process measurements, it can be challenging to compare the results. Therefore it is vital to understand both the limitations of specific probes and uncertainties introduced by processing algorithms. Since there is currently no universally accepted framework regarding how in-situ measurements should be processed, there is a need for a general reference that describes the most commonly applied algorithms along with their strengths and weaknesses. Methods used to process data from bulk water probes, single particle light scattering spectrometers and cloud imaging probes are reviewed herein, with emphasis on measurements of the ice phase. Particular attention is paid to how uncertainties, caveats and assumptions in processing algorithms affect derived products since there is currently no consensus on the optimal way of analyzing data. Recommendations for improving the analysis and interpretation of in-situ data include the following: establishment of a common reference library of individual processing algorithms; better documentation of assumptions used in these algorithms; development and maintenance of sustainable community software for processing in-situ observations; and more studies that compare different algorithms with the same benchmark data sets

    Multi-Year Analysis of Rain-Snow Levels at Marquette, Michigan

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    This study uses observations from a ground-based instrument suite to investigate the rain-snow level (RSL) in stratiform rainfall from January 2014 to April 2020 in the Upper Great Lakes Region. The height above the surface where ice melts to rain, the rain-snow level, influences microphysical assumptions in remote sensing precipitation retrievals and the ability of space-based radar to discriminate surface precipitation phase because of ground clutter. The instrument suite is installed at the Marquette, MI (MQT) National Weather Service station adjacent to Lake Superior. Rain events and the RSLs are studied through a ground-based vertically profiling radar (Micro Rain Radar), a custom NASA-developed video disdrometer (Precipitation Imaging Package), and reanalysis products from ECMWF ERA5 and NASA MERRA-2. Distinct macro and microphysical characteristics are observed in precipitation events with shallow RSLs (1.8 km AGL). Intermediate RSLs correspond to rain events with relatively higher rain rates and a higher concentration of small drops in the drop size distributions (DSDs). Shallow RSL DSDs contain relatively higher concentrations of large drops with lower fall speeds suggesting that partially melted snowflakes may be reaching the surface. Reflectivity-rain-rate relationships are also impacted by microphysical differences associated with RSL regimes. Radar-detected RSLs agree with reanalysis-derived melt levels-especially at wet-bulb isotherms of 0.5°C and 1°C. Seasonal differences such as shallow RSLs in winter, fall, and spring have subsequent implications for satellite detectability.Plain Language SummaryThe height above the surface where falling snow melts to rain, the rain-snow level (RSL), can be detected by both ground-based and space-based radars. However, space-based radars are limited in their ability to capture precipitation near the surface due to interference. This work investigates RSLs between January 2014 and April 2020 from ground-based observations at the Marquette, MI National Weather Service office. This work includes observations from ground-based profiling radar and a custom NASA-developed instrument that records high resolution videos of precipitation at the surface. In addition, profile temperature and moisture data are used. These products are commonly used with satellite observations to determine the surface precipitation phase. The results show different characteristics for rain events with shallow and intermediate RSLs. The radar-detected RSLs illustrate good agreement with melt levels derived from reanalysis profile data, which is useful for satellite retrievals of precipitation. Seasonal differences such as shallow rain-snow levels in winter, fall, and spring have subsequent implications for satellite detectability.Key PointsRain-snow levels (RSLs) are shallow in winter. In autumn and spring, RSLs span the full range of the profiling radarRainfall microphysical characteristics and rates vary with RSLsRSLs determined from vertically profiling radar Doppler velocity correlate well with reanalysis derived melt levelsPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/175770/1/jgrd58447_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/175770/2/jgrd58447.pd
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