EFFECTS OF PARTIAL REPLACEMENT OF SAND WITH LATERITIC SOIL IN SANDCRETE BLOCKS

Of recent, the attention of most researchers is shifting towards the optimization of building materials by using local contents; the use of indigenous materials; and local industrial by-products unique and abundant in certain localities. This study therefore explored ways in which lateritic soil could be utilised in hollow sandcrete block production in Ota, Ogun State, Nigeria. Sandcrete blocks were made with lateritic soil taken from different sources replacing the conventional fine aggregate (local river sand) in steps of 10% up to 60%. Their compressive strengths determined to check for conformity with standard sandcrete block as specified in the Nigerian National Building Code (2006) with a view to determine the acceptable percentage replacement. Soil tests were performed on the lateritic soil samples to characterise the soils. Classification of the lateritic soil samples within Ota, revealed that the lateritic soils are mostly sandy clay of high plasticity and may replace sand by up to 20%, though an approximate linear decrease in strength with increasing sand replacement with lateritic soil was observed. This percentage replacement can be recommended to the block making industries within Ota with a view to encouraging utilization, though it is encouraged to confirm the percentage before embarking on mass block production

EVALUATION OF THE LEVEL OF COMPLIANCE WITH CONSTRUCTION DESIGN MANAGEMENT (CDM 2007) REGULATIONS BY CLIENTS IN NIGERIA

The study evaluated the level of compliance with Construction Design Management (CDM) regulation by Nigerian clients based on the main duties of the client as stipulated in CDM regulation specification. To achieve this goal, sixty (60) questionnaires were distributed among construction firms and clients involved in the execution of projects in Lagos State in Nigeria. The survey showed that the client`s level of compliance based on the CDM regulation on client duty’s requirement has not been encouraging. The regulation requires that enough information should be given by the client; the study found that clients did not give enough information especially on building and number of the floor to be constructed also on the units of accommodation, land survey and report on soil investigation. Most of the respondents believed that the problem associated with the level of client compliance to CDM, includes poor level of communication and inadequate time allowed by the client at every stage in the construction process. In addition, some of the amenities that exist on the construction site are toilets and changing rooms while the sickbay which is important is the least to be found in the construction sites. Also the necessary amenities and are not place in the construction sites. The level of awareness of CDM regulation among the construction workers is low but client is meant to make the information available adequately as contained in the CDM regulation. It should be noted that however, that the problems on the health and safety might have effect on performance of the construction industry in terms of cost, time and quality of the construction. It is therefore concluded that Construction Design Management (CDM) regulation is not fully known among the construction industry’s client, contractors and site workers. The study recommended that for improved services, efforts should be made by project managers to create the awareness 42 Covenant Journal of Research in the Built Environment (CJRBE) Vol. 1, No. 1 (Maiden Edition), June, 2014.while clients attend short course and seminars on CDM regulation.The consulting firms of the project manager are enjoyed to improve on the necessary amenities available on the construction site and at the same time, the construction design management regulation should be conspicuously placed so that construction workers can have access to and be fully aware of the regulations. Finally, the client should appoint a CDM co -coordinator for each project site and that there should be agencies to monitor the implementation of the CDM regulation

Effects of Partial Replacement of Sand with Lateritic Soil in Sandcrete Blocks

Of recent, the attention of most researchers is shifting towards the optimization of building materials by using local contents; the use of indigenous materials; and local industrial by-products unique and abundant in certain localities. This study therefore explored ways in which lateritic soil could be utilised in hollow sandcrete block production in Ota, Ogun State, Nigeria. Sandcrete blocks were made with lateritic soil taken from different sources replacing the conventional fine aggregate (local river sand) in steps of 10% up to 60%. Their compressive strengths determined to check for conformity with standard sandcrete block as specified in the Nigerian National Building Code (2006) with a view to determine the acceptable percentage replacement. Soil tests were performed on the lateritic soil samples to characterise the soils. Classification of the lateritic soil samples within Ota, revealed that the lateritic soils are mostly sandy clay of high plasticity and may replace sand by up to 20%, though an approximate linear decrease in strength with increasing sand replacement with lateritic soil was observed. This percentage replacement can be recommended to the block making industries within Ota with a view to encouraging utilization, though it is encouraged to confirm the percentage before embarking on mass block productio

Psychosis with paranoid delusions after a therapeutic dose of mefloquine: a case report

BACKGROUND: Convenient once-a-week dosing has made mefloquine a popular choice as malaria prophylaxis for travel to countries with chloroquine-resistant malaria. However, the increased use of mefloquine over the past decade has resulted in reports of rare, but severe, neuropsychiatric adverse reactions, such as anxiety, depression, hallucinations and psychosis. A direct causality between mefloquine and severe reactions among travelers has been partly confounded by factors associated with foreign travel and, in the case of therapeutic doses of mefloquine, the central nervous system manifestations of Plasmodium infection itself. The present case provides a unique natural history of mefloquine-induced neuropsychiatric toxicity and revisits its dose-dependent nature. CASE PRESENTATION: This report describes an acute exacerbation of neuropsychiatric symptoms after an unwarranted therapeutic dose (1250 mg) of mefloquine in a 37-year-old male previously on a once-a-week prophylactic regimen. Neuropsychiatric symptoms began as dizziness and insomnia of several days duration, which was followed by one week of escalating anxiety and subtle alterations in behaviour. The patient's anxiety culminated into a panic episode with profound sympathetic activation. One week later, he was hospitalized after developing frank psychosis with psychomotor agitation and paranoid delusions. His psychosis remitted with low-dose quetiapine. CONCLUSION: This report suggests that an overt mefloquine-induced psychosis can be preceded by a prodromal phase of moderate symptoms such as dizziness, insomnia, and generalized anxiety. It is important that physicians advise patients taking mefloquine prophylaxis and their relatives to recognize such symptoms, especially when they are accompanied by abrupt, but subtle, changes in behaviour. Patients with a history of psychiatric illness, however minor, may be at increased risk for a mefloquine-induced neuropsychiatric toxicity. Physicians must explicitly caution patients not to self-medicate with a therapeutic course of mefloquine when a malaria diagnosis has not been confirmed

EVALUATION OF THE LEVEL OF COMPLIANCE WITH CONSTRUCTION DESIGN MANAGEMENT (CDM 2007) REGULATIONS BY CLIENTS IN NIGERIA

The study evaluated the level of compliance with Construction Design Management (CDM) regulation by Nigerian clients based on the main duties of the client as stipulated in CDM regulation specification. To achieve this goal, sixty (60) questionnaires were distributed among construction firms and clients involved in the execution of projects in Lagos State in Nigeria. The survey showed that the client`s level of compliance based on the CDM regulation on client duty’s requirement has not been encouraging. The regulation requires that enough information should be given by the client; the study found that clients did not give enough information especially on building and number of the floor to be constructed also on the units of accommodation, land survey and report on soil investigation. Most of the respondents believed that the problem associated with the level of client compliance to CDM, includes poor level of communication and inadequate time allowed by the client at every stage in the construction process. In addition, some of the amenities that exist on the construction site are toilets and changing rooms while the sickbay which is important is the least to be found in the construction sites. Also the necessary amenities and are not place in the construction sites. The level of awareness of CDM regulation among the construction workers is low but client is meant to make the information available adequately as contained in the CDM regulation. It should be noted that however, that the problems on the health and safety might have effect on performance of the construction industry in terms of cost, time and quality of the construction. It is therefore concluded that Construction Design Management (CDM) regulation is not fully known among the construction industry’s client, contractors and site workers. The study recommended that for improved services, efforts should be made by project managers to create the awareness 42 Covenant Journal of Research in the Built Environment (CJRBE) Vol. 1, No. 1 (Maiden Edition), June, 2014.while clients attend short course and seminars on CDM regulation.The consulting firms of the project manager are enjoyed to improve on the necessary amenities available on the construction site and at the same time, the construction design management regulation should be conspicuously placed so that construction workers can have access to and be fully aware of the regulations. Finally, the client should appoint a CDM co -coordinator for each project site and that there should be agencies to monitor the implementation of the CDM regulation

EVALUATION OF THE LEVEL OF COMPLIANCE WITH CONSTRUCTION DESIGN MANAGEMENT (CDM 2007) REGULATIONS BY CLIENTS IN NIGERIA

The study evaluated the level of compliance with Construction Design Management (CDM) regulation by Nigerian clients based on the main duties of the client as stipulated in CDM regulation specification. To achieve this goal, sixty (60) questionnaires were distributed among construction firms and clients involved in the execution of projects in Lagos State in Nigeria. The survey showed that the client`s level of compliance based on the CDM regulation on client duty’s requirement has not been encouraging. The regulation requires that enough information should be given by the client; the study found that clients did not give enough information especially on building and number of the floor to be constructed also on the units of accommodation, land survey and report on soil investigation. Most of the respondents believed that the problem associated with the level of client compliance to CDM, includes poor level of communication and inadequate time allowed by the client at every stage in the construction process. In addition, some of the amenities that exist on the construction site are toilets and changing rooms while the sickbay which is important is the least to be found in the construction sites. Also the necessary amenities and are not place in the construction sites. The level of awareness of CDM regulation among the construction workers is low but client is meant to make the information available adequately as contained in the CDM regulation. It should be noted that however, that the problems on the health and safety might have effect on performance of the construction industry in terms of cost, time and quality of the construction. It is therefore concluded that Construction Design Management (CDM) regulation is not fully known among the construction industry’s client, contractors and site workers. The study recommended that for improved services, efforts should be made by project managers to create the awareness 42 Covenant Journal of Research in the Built Environment (CJRBE) Vol. 1, No. 1 (Maiden Edition), Jan. 2014. while clients attend short course and seminars on CDM regulation.The consulting firms of the project manager are enjoyed to improve on the necessary amenities available on the construction site and at the same time, the construction design management regulation should be conspicuously placed so that construction workers can have access to and be fully aware of the regulations. Finally, the client should appoint a CDM co-coordinator for each project site and that there should be agencies to monitor the implementation of the CDM regulation

Treatment outcomes of immune-related cutaneous adverse events

PURPOSE: The aim of the current study was to report the efficacy of topical and systemic treatments for immune-related cutaneous adverse events (ircAEs) attributed to checkpoint inhibitors in an uncontrolled cohort of patients referred to oncodermatology clinics. METHODS: A retrospective analysis of patients with ircAEs evaluated by dermatologists from January 1, 2014, to December 31, 2017, at three tertiary care hospitals and cancer centers were identified through electronic medical records. Clinicopathologic characteristics, dermatologic therapy outcome, and laboratory data were analyzed. RESULTS: A total of 285 patients (median age, 65 years [range, 17 to 89 years]) with 427 ircAEs were included: pruritus (n = 138; 32%), maculopapular rash (n = 120; 28%), psoriasiform rash (n = 22; 5%), and others (n = 147; 34%). Immune checkpoint inhibitor class was associated with ircAE phenotype (P = .007), where maculopapular rash was predominant in patients who received combination therapy. Severity of ircAEs was significantly reduced (mean Common Terminology Criteria for Adverse Events grade: 1.74 v 0.71; P, .001) with dermatologic interventions, including topical corticosteroids, oral antipruritics, and systemic immunomodulators. A total of 88 ircAEs (20%) were managed with systemic immunomodulators. Of these, 22 (25%) of 88 persisted or worsened. In seven patients with corticosteroid-refractory ircAEs, improvement resulted from targeted biologic immunomodulatory therapies that included rituximab and dupilumab. Serum interleukin-6 (IL-6) was elevated in 34 (52%) of 65 patients; grade 3 or greater ircAEs were associated with increased absolute eosinophils (odds ratio, 4.1; 95% CI, 1.3 to 13.4) and IL-10 (odds ratio, 23.8; 95% CI, 2.1 to 262.5); mean immunoglobulin E serum levels were greater in higher-grade ircAEs: 1,093 kU/L (grade 3), 245 kU/L (grade 2), and 112 kU/L (grade 1; P = .043). CONCLUSION: Most ircAEs responded to symptom- and phenotype-directed dermatologic therapies, whereas biologic therapies were effective in patients with corticosteroid-refractory disease. Increased eosinophils, IL-6, IL-10, and immunoglobulin E were associated with ircAEs, and they may represent actionable therapeutic targets for immune-related skin toxicities