Dynamic simulation of dispersed gas-liquid two-phase flow using a discrete bubble model.

In this paper a detailed hydrodynamic model for gas-liquid two-phase flow will be presented. The model is based on a mixed Eulerian-Lagrangian approach and describes the time-dependent two-dimensional motion of small, spherical gas bubbles in a bubble column operating in the homogeneous regime. The motion of these bubbles is calculated from a force balance for each individual bubble, accounting for all relevant forces acting on them. Contributions from liquid-phase pressure gradient, drag, virtual mass, liquid-phase vorticity and gravity are considered, whereas direct bubble-bubble interactions are accounted for via an interaction model resembling the collision model developed by Hoomans et al. (1996) to model gas-fluidized beds. The liquid-phase hydrodynamics are described using the volume-averaged, unsteady, Navier-Stokes equations. A preliminary model validation has been performed by comparing the computational results with experimental observations published previously in literature by various authors. The model is shown to predict correctly the motion of a bubble plume in a pseudo-two-dimensional bubble column operated at different superficial gas velocities, provided that a detailed description of the bubble dynamics is incorporated in the model. The effect of bubble column aspect ratio on the hydrodynamic behaviour of the column has also been investigated. Our model predicts the effect of aspect ratio on the flow structure in the bubble column. The importance of the various forces acting on the bubbles will also be discussed and it will be shown that the added mass force and the lift force cannot be neglected in bubble column simulation. Finally, the model has been used to study the start-up behaviour of a two-dimensional bubble column. It will be shown that the history of the gas-liquid two-phase flow significantly affects the flow structure ultimately obtained in a bubble column. This finding has, to our knowledge, not been reported before in literature

Acquired Brain Injury and Interventions in the Offender Population: A Systematic Review

Background and Aims: The prevalence of acquired brain injury (ABI) in offender populations appears much higher than in the general population, being estimated at 50% compared to 12%, respectively. Taking into account ABI-related cognitive and social impairments or behavioral changes in forensic treatments might be relevant and may improve treatment outcomes. The aim of the current review is to summarize and integrate the literature on psychological interventions or treatments for consequences of ABI in the forensic setting. Reviewing this literature could provide crucial information for improving treatment options for offenders with ABI, which may contribute to reducing recidivism. Methods: The PubMed/MEDLINE, PsychInfo, CINAHL, COCHRANE, and Web of Science databases were searched for studies in adult offenders with ABI that evaluated the effect of psychological interventions with a focus on ABI-related impairments and recidivism. Results: This review identified four intervention studies that met the inclusion criteria. These included an adult population (≥18-year-old) in a forensic setting (given the focus of the current review on treatment, defined here as an environment in which offenders are treated while being incarcerated or as outpatients), non-pharmacological treatments and were published in English or Dutch between 2005 and 2020. All studies reported some positive effects of the intervention on interpersonal behavior, cognition and recidivism. The aspects of the interventions that seemed most beneficial included personalized treatment and re-entry plans, support for the individual and their environment and psychoeducation about the effects of ABI. Discussion: Although positive effects were reported in the studies reviewed, all studies had methodological limitations in terms of sample size, study design and outcome measures which affects the strength of the evidence. This limits strong conclusions and generalizability to the entire offender population. Conclusion: Despite high prevalence of ABI in offender populations, interventions in forensic settings seldom address the effect of ABI. The few studies that did take ABI into account reported positive effects, but those results should be interpreted with caution. Future studies are warranted, since this does seem an important venue to improve treatment, which could eventually contribute to reducing recidivism

Suppression of airway inflammation by Illicium verum and trans-anethole

_Background_ SH2 domain containing inositol-5-phosphatase (SHIP1) is an important modulator of innate and adaptive immunity. In mice, loss of SHIP1 provokes severe ileitis resembling Crohn's disease (CD), as a result of deregulated immune responses, altered cytokine production and intestinal fibrosis. Recently, SHIP1 activity was shown to be correlated to the presence of a CD-associated single nucleotide polymorphism in ATG16L1. Here, we studied SHIP1 activity and expression in an adult cohort of CD patients. _Methods_ SHIP1 activity, protein and mRNA expression in peripheral blood mononuclear cells from CD patients in clinical remission were determined by Malachite green assay, Western blotting an

A Tractable Stochastic Model of Correlated Link Failures Caused by Disasters

In order to evaluate the expected availability of a service, a network administrator should consider all possible failure scenarios under the specific service availability model stipulated in the corresponding service-level agreement. Given the increase in natural disasters and malicious attacks with geographically extensive impact, considering only independent single link failures is often insufficient. In this paper, we build a stochastic model of geographically correlated link failures caused by disasters, in order to estimate the hazards a network may be prone to, and to understand the complex correlation between possible link failures. With such a model, one can quickly extract information, such as the probability of an arbitrary set of links to fail simultaneously, the probability of two nodes to be disconnected, the probability of a path to survive a failure, etc. Furthermore, we introduce a pre-computation process, which enables us to succinctly represent the joint probability distribution of link failures. In particular, we generate, in polynomial time, a quasilinear-sized data structure, with which the joint failure probability of any set of links can be computed efficiently.Embedded and Networked System

The effect of electro-anatomical mapping on the success rate and fluoroscopy time in supra-ventricular tachycardia ablation in children: single centre retrospective study

Aims: To evaluate the effect of electro-anatomical mapping on success rate and fluoroscopy time in ablation of supraventricular tachycardia substrates in a large group of children. Methods: Patients referred from multiple centres in the Netherlands and who received a first ablation for supraventricular tachycardia substrates in the Leiden University Medical Center between 2014 and 2020 were included in this retrospective cohort study. They were divided in procedures in patients with fluoroscopy and procedures in patients using electro-anatomical mapping. Results: Outcomes of ablation of 373 electro-anatomical substrates were analysed. Acute success rate in the fluoro-group (n = 170) was 95.9% compared to 94.5% in the electro-anatomical mapping group (n = 181) (p = 0.539); recurrence rate was 6.1% in the fluoro-group and 6.4% in the electro-anatomical mapping group (p = 0.911) after a 12-months follow-up. Redo-ablations were performed in 12 cases in the fluoro-group and 10 cases in the electro-anatomical mapping group, with a success rate of 83.3% versus 80.0%, resulting in an overall success rate of 95.9% in the fluoro-group and 92.8% in the electro-anatomical mapping group (p = 0.216) after 12 months. Fluoroscopy time and dose area product decreased significantly from 16.00 +/- 17.75 minutes (median +/- interquartile range) to 2.00 +/- 3.00 minutes (p = 0.000) and 210.5 mu Gym(2) +/- 249.3 to 32.9 mu Gym(2) +/- 78.6 (p = 0.000), respectively. In the fluoro-group, four complications occurred (2.0%) and in the electro-anatomical mapping group no complications occurred. Conclusion: These results demonstrate that ablations of supra-ventricular tachycardia substrates in children remain a highly effective and safe treatment after the introduction of electro-anatomical mapping as a standard of care, while significantly reducing fluoroscopy time and dose area product.Developmen

Probabilistic Shared Risk Link Groups Modeling Correlated Resource Failures Caused by Disasters

To evaluate the expected availability of a backbone network service, the administrator should consider all possible failure scenarios under the specific service availability model stipulated in the corresponding service-level agreement. Given the increase in natural disasters and malicious attacks with geographically extensive impact, considering only independent single component failures is often insufficient. This paper builds a stochastic model of geographically correlated link failures caused by disasters to estimate the hazards an optical backbone network may be prone to and to understand the complex correlation between possible link failures. We first consider link failures only and later extend our model also to capture node failures. With such a model, one can quickly extract essential information such as the probability of an arbitrary set of network resources to fail simultaneously, the probability of two nodes to be disconnected, the probability of a path to survive a disaster. Furthermore, we introduce standard data structures and a unified terminology on Probabilistic Shared Risk Link Groups (PSRLGs), along with a pre-computation process, which represents the failure probability of a set of resources succinctly. In particular, we generate a quasilinear-sized data structure in polynomial time, which allows the efficient computation of the cumulative failure probability of any set of network elements. Our evaluation is based on carefully pre-processed seismic hazard data matched to real-world optical backbone network topologies.Accepted author manuscriptEmbedded and Networked System

Overexpression of Cystathionine gamma-Lyase Suppresses Detrimental Effects of Spinocerebellar Ataxia Type 3

Spinocerebellar ataxia type 3 (SCA3) is a polyglutamine (polyQ) disorder caused by a CAG repeat expansion in the ataxin-3 (ATXN3) gene resulting in toxic protein aggregation. Inflammation and oxidative stress are considered secondary factors contributing to the progression of this neurodegenerative disease. There is no cure that halts or reverses the progressive neurodegeneration of SCA3. Here we show that overexpression of cystathionine.-lyase, a central enzyme in cysteine metabolism, is protective in a Drosophila model for SCA3. SCA3 flies show eye degeneration, increased oxidative stress, insoluble protein aggregates, reduced levels of protein persulfidation and increased activation of the innate immune response. Overexpression of Drosophila cystathionine.-lyase restores protein persulfidation, decreases oxidative stress, dampens the immune response and improves SCA3-associated tissue degeneration. Levels of insoluble protein aggregates are not altered; therefore, the data implicate a modifying role of cystathionine.-lyase in ameliorating the downstream consequence of protein aggregation leading to protection against SCA3-induced tissue degeneration. The cystathionine.-lyase expression is decreased in affected brain tissue of SCA3 patients, suggesting that enhancers of cystathionine.-lyase expression or activity are attractive candidates for future therapies

Personalized peptide-based vaccination for treatment of colorectal cancer: rational and progress

Colorectal cancer (CRC) is one of the most common cancers globally and is associated with a high rate of morbidity and mortality. A large proportion of patients with early stage CRC who undergo conventional treatments develop local recurrence or distant metastasis and in this group of advanced disease, the survival rate is low. Furthermore there is often a poor response and/or toxicity associated with chemotherapy and chemo-resistance may limit continuing conventional treatment alone. Choosing novel and targeted therapeutic approaches based on clinicopathological and molecular features of tumors in combination with conventional therapeutic approach could be used to eradicate residual micrometastasis and therefore improve patient prognosis and also be used preventively. Peptide-based vaccination therapy is one class of cancer treatment that could be used to induce tumor-specific immune responses, through the recognition of specific antigen-derived peptides in tumor cells, and this has emerged as a promising anti-cancer therapeutic strategy. The aim of this review was to summarize the main findings of recent studies in exciting field of peptide-based vaccination therapy in CRC patients as a novel therapeutic approach in treatment of CRC