Resonance-enhanced multiphoton ionization photoelectron spectroscopy of Rydberg states of N2O below the X ionization limit

A three-photon resonance-enhanced multiphoton ionization spectroscopic study on N2O is carried out in the spectral range from 80 000 cm - 1 up to the lowest ionization limit at 103 963 cm - 1. High-resolution photoelectron spectroscopy is used to identify and characterize the observed excited states. Eighteen origins are reported which have either not been assigned before or are reassigned now. Moreover, the photoelectron spectra taken at higher-lying resonances often show extensive vibronic coupling with the near-resonant vibronic manifolds built on lower-lying origins

Infarct size and left ventricular function in the PRoximal Embolic Protection in Acute myocardial infarction and Resolution of ST-segment Elevation (PREPARE) trial: ancillary cardiovascular magnetic resonance study

Objectives The aim of the study was to evaluate whether primary percutaneous coronary intervention (PCI) with combined proximal embolic protection and thrombus aspiration results in smaller final infarct size and improved left ventricular function assessed by cardiovascular magnetic resonance (CMR) in ST-segment elevation myocardial infarction (STEMI) patients compared with primary PCI alone. Background Primary PCI with the Proxis system improves immediate microvascular flow post-procedure as measured by ST-segment resolution, which could result in better outcomes. Methods The ancillary CMR study included 206 STEMI patients who were enrolled in the PRoximal Embolic Protection in Acute myocardial infarction and Resolution of ST-Elevation (PREPARE) trial. CMR imaging was assessed between 4 and 6 months after the index procedure. Results There were no significant differences in final infarct size (6.1 g/m(2) vs 6.3 g/m(2), p=0.78) and left ventricular ejection fraction (50% vs 50%, p=0.46) between both groups. Also, systolic wall thickening in the infarct area (44% vs 45%, p=0.93) or the extent of transmural segments (8.3% of segments vs 8.3% of segments, p=0.60) showed no significant differences. The incidence of major adverse cardiac and cerebral events at 6 months was similar in the Proxis and control group (8% vs 10%, respectively, p=0.43). Conclusions Primary PCI with combined proximal embolic protection and thrombus aspiration in STEMI patients did not result in significant differences in final infarct size or left ventricular function at follow-up CMR. In addition, there was no difference in the incidence of major adverse cardiac and cerebral events at 6 month

Proximal embolic protection in patients undergoing primary angioplasty for acute myocardial infarction (PREPARE): core lab adjudicated angiographic outcomes of a randomised controlled trial

Background Patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI) with the Proms system (St Jude Medical, St Paul, MN, USA) achieved significantly better microvascular flow as measured by ST-segment resolution However, no differences were observed in left ventricular ejection fraction or infarct size as obtained by cardiovascular magnetic resonance imaging The goal of the present study was to evaluate the effect of combined proximal embolic protection and thrombus aspiration on core lab adjudicated angiographic outcomes Methods In the PRoximal Embolic Protection in Acute myocardial infarction and Resolution of ST Elevation (PREPARE) study, patients were randomised to primary PCI with the Proms system (n=141) or primary PCI alone (n=143) An independent core laboratory re-evaluated all angiograms and adjudicated the angiographic outcomes and computerised quantitative blush evaluation (QuBE) value Results There were no significant differences in Thrombolysis In Myocardial Infarction (TIMI) flow grade, myocardial blush grade, or angiographic signs of distal embolisation among the two arms QuBE values did not significantly differ between the Proxis-treated patients and control patients (15 1 +/- 5 4 vs 15 8 +/- 5 5, respectively, p=0 34) Conclusion Primary PCI with combined proximal embolic protection and thrombus aspiration in STEMI patients more frequently resulted in complete immediate ST resolution compared with control patients However, there were no significant differences in core laboratory adjudicated angiographic outcomes (Neth Heart J 2010,18 531-6