1 research outputs found
The role molecular-genetic factors in the development of the weakness of labor in first labor women
Objective: The study of energy metabolism of the myometrium at coordinated (MRC) and the weak labor activity (Wed), identify molecular-genetic predictors of uterine inertia. Subject and methods. In a prospective cohort study included 110 nulliparous women, the clinical course of labor allocated to two groups: I (main) - births proceeded from the weakness of labor (n=62), II (comparison group) - coordinated labor (n=48). A molecular genetic study of polymorphism of genes of the energy exchange method of pyrosequencing. Results. Morphological studies showed the presence of a disturbance of cellular energy metabolism of the myocytes with Wed. Revealed a protective role of genotypes at the polymorphic marker gene PPARA2498 G>C, variant allele T of the polymorphism in the PPARD -87, both homozygous variants PPARGC A203P1Π genotypes GG and SS for Wed. Conclusion. The results of the study can contribute to predicting the weakness of labor in young somatically healthy with physiological pregnancy first labor women.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊ ΡΠ½Π΅ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° ΠΌΠΈΠΎΠΌΠ΅ΡΡΠΈΡ ΠΏΡΠΈ ΠΊΠΎΠΎΡΠ΄ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ (ΠΠ Π) ΠΈ ΡΠ»Π°Π±ΠΎΠΉ ΡΠΎΠ΄ΠΎΠ²ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ (Π‘Π Π), Π²ΡΡΠ²Π»Π΅Π½ΠΈΠ΅ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠ΅Π΄ΠΈΠΊΡΠΎΡΠΎΠ² ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠ»Π°Π±ΠΎΡΡΠΈ ΡΠΎΠ΄ΠΎΠ²ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄. Π ΠΏΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅ ΠΊΠΎΠ³ΠΎΡΡΠ½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΠΊΠ»ΡΡΠ΅Π½Ρ 110 ΠΏΠ΅ΡΠ²ΠΎΡΠΎΠ΄ΡΡΠΈΡ
ΠΆΠ΅Π½ΡΠΈΠ½, ΠΏΠΎ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌΡ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΡΠΎΠ΄ΠΎΠ² Π²ΡΠ΄Π΅Π»Π΅Π½Ρ Π΄Π²Π΅ Π³ΡΡΠΏΠΏΡ: I (ΠΎΡΠ½ΠΎΠ²Π½Π°Ρ) - ΡΠΎΠ΄Ρ ΠΏΡΠΎΡΠ΅ΠΊΠ°Π»ΠΈ ΡΠΎ ΡΠ»Π°Π±ΠΎΡΡΡΡ ΡΠΎΠ΄ΠΎΠ²ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ {n=62), II (Π³ΡΡΠΏΠΏΠ° ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ) - Ρ ΠΊΠΎΠΎΡΠ΄ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΡΠΎΠ΄ΠΎΠ²ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΡΡ (ΠΏ=48). ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π³Π΅Π½ΠΎΠ² ΡΠ½Π΅ΡΠ³ΠΎΠΎΠ±ΠΌΠ΅Π½Π° ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΏΠΈΡΠΎΡΠ΅ΠΊΠ²ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. ΠΡΡΠ²Π»Π΅Π½Π° ΠΏΡΠΎΡΠ΅ΠΊΡΠΈΠ²Π½Π°Ρ ΡΠΎΠ»Ρ Π³Π΅Π½ΠΎΡΠΈΠΏΠΎΠ² ΠΏΠΎ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠ½ΠΎΠΌΡ ΠΌΠ°ΡΠΊΠ΅ΡΡ Π³Π΅Π½Π° PPARA2498 G>C ΠΈ Π²Π°ΡΠΈΠ°Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π»Π»Π΅Π»Ρ Π’ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° PPARD -87, ΠΎΠ±Π° Π³ΠΎΠΌΠΎΠ·ΠΈΠ³ΠΎΡΠ½ΡΡ
Π²Π°ΡΠΈΠ°Π½ΡΠΎΠ² PPARGC1Π Π203Π Π³Π΅Π½ΠΎΡΠΈΠΏΠΎΠ² GG ΠΈ Π‘Π‘ Π΄Π»Ρ Π‘Π Π. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΌΠΎΠ³ΡΡ Π²Π½Π΅ΡΡΠΈ ΡΠ²ΠΎΠΉ Π²ΠΊΠ»Π°Π΄ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ»Π°Π±ΠΎΡΡΠΈ ΡΠΎΠ΄ΠΎΠ²ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Ρ ΠΌΠΎΠ»ΠΎΠ΄ΡΡ
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