3 research outputs found
Synthesis and Antimicrobial Activity of New Drimane and Homodrimane Sesquiterpenoids with Oxadiazole and Thiadiazole Fragments
No full textEnantiospecific, biosynthetically inspired formal total synthesis of (+)-Liphagal
No full textA biosynthetically inspired synthesis of (+)-liphagal has been achieved from (+)-sclareolide in 13 steps (9% overall yield). The key step is a biomimetic ring expansion of a highly stabilized benzylic carbocation, which generates the seven-membered ring and the benzofuran of the natural product in a single cascade reaction.Jonathan H. George, Jack E. Baldwin and Robert M. Adlingto
