ASCA Observations of Two Ultra-Luminous Compact X-Ray Sources in the Edge-on Spiral Galaxy NGC 4565

The edge-on spiral galaxy NGC 4565 was observed for $\sim$ 35 ks with ASCA in the 0.5-10 keV energy band. The X-ray emission was dominated by two bright sources, which can be identified with two point-like X-ray sources seen in the ROSAT HRI image. The observed 0.5-10 keV fluxes of these sources, $1.7 \times 10^{-12} erg/s cm^{-2}$ and $0.7 \times 10^{-12}erg/s cm^{-2}$, %$1.66 \times 10^{-12} erg/s cm^{-2}$ %$0.66 \times 10^{-12} erg/s cm^{-2}$ imply bolometric luminosities of $1.0\times 10^{40} erg/s$ and $4 \times 10^{39} erg/s$, respectively. They exhibit similar spectra, which can be explained by emission from optically thick accretion disks with the inner disk temperature of 1.4-1.6 keV. One of them, coincident in position with the nucleus, shows too low absorption to be the active nucleus seen through the galaxy disk. Their spectra and high luminosities suggest that they are both mass accreting black hole binaries. However the black-hole mass required by the Eddington limit is rather high ($\geq 50 M_{\odot}$), and the observed disk temperature is too high to be compatible with the high black-hole mass. Several attempts are made to solve these problesms.Comment: 20page

Polyamine depletion induces G1 and S phase arrest in human retinoblastoma Y79 cells

<p>Abstract</p> <p>Background</p> <p>Polyamines and ornithine decarboxylase (ODC) are essential for cell proliferation. DL-α-difluoromethylornithine (DFMO), a synthetic inhibitor of ODC, induces G₁arrest through dephosphorylation of retinoblastoma protein (pRb). The effect of DFMO on cell growth of pRb deficient cells is not known. We examined the effects of DFMO on pRb deficient human retinoblastoma Y79 cell proliferation and its molecular mechanism.</p> <p>Methods</p> <p>Using cultured Y79 cells, the effects of DFMO were studied by using polyamine analysis, western blot, gel shift, FACS and promoter analysis.</p> <p>Results</p> <p>DFMO suppressed the proliferation of Y79 cells, which accumulated in the G1 and S phase. DFMO induced p27/Kip1 protein expression, p107 dephosphorylation and accumulation of p107/E2F-4 complex in Y79 cells.</p> <p>Conclusion</p> <p>These results indicate that p107 dephosphorylation and accumulation of p107/E2F-4 complex is involved in G₁and S phase arrest of DFMO treated Y79 cells.</p

Role of KIT-Positive Interstitial Cells of Cajal in the Urinary Bladder and Possible Therapeutic Target for Overactive Bladder

In the gastrointestinal tract, interstitial cells of Cajal (ICCs) act as pacemaker cells to generate slow wave activity. Interstitial cells that resemble ICCs in the gastrointestinal tract have been identified by their morphological characteristics in the bladder. KIT is used as an identification marker of ICCs. ICCs in the bladder may be involved in signal transmission between smooth muscle bundles, from efferent nerves to smooth muscles, and from the urothelium to afferent nerves. Recent research has suggested that not only the disturbance of spontaneous contractility caused by altered detrusor ICC signal transduction between nerves and smooth muscle cells but also the disturbance of signal transduction between urothelial cells and sensory nerves via suburothelial ICC may induce overactive bladder (OAB). Recent reports have suggested that KIT is not only a detection marker of these cells, but also may play a crucial role in the control of bladder function. Research into the effect of a c-kit receptor inhibitor, imatinib mesylate, on bladder function implies that KIT-positive ICCs may be therapeutic target cells to reduce bladder overactivity and that the blockage of c-kit receptor may offer a new therapeutic strategy for OAB treatment, although further study will be needed

Reducing nonideal to ideal coupling in random matrix description of chaotic scattering: Application to the time-delay problem

We write explicitly a transformation of the scattering phases reducing the problem of quantum chaotic scattering for systems with M statistically equivalent channels at nonideal coupling to that for ideal coupling. Unfolding the phases by their local density leads to universality of their local fluctuations for large M. A relation between the partial time delays and diagonal matrix elements of the Wigner-Smith matrix is revealed for ideal coupling. This helped us in deriving the joint probability distribution of partial time delays and the distribution of the Wigner time delay.Comment: 4 pages, revtex, no figures; published versio

Effect of antibiotic therapy on the inflammatory responses during streptococcal pneumonia in emphysematous mice

Background and objective: Bacterial infection is one of the most important causes of acute exacerbation of respiratory failure in patients with chronic obstructive pulmonary disease (COPD). There were few studies evaluating the effects of early intervention by antibiotic on respiratory bacterial infection in COPD subjects. We investigated the effect of early intervention by respiratory quinolone antibiotic on the systemic inflammatory responses induced by streptococcal pneumonia using a mouse model of experimental emphysema. Methods: Experimental pulmonary emphysema was developed by a single intratracheal instillation of porcine pancreatic elastase in ICR mice. Three weeks later, lethal doses of Streptococcus pneumoniae were intratracheally inoculated, followed by oral administration of 50 mg/kg body weight of Grepafloxacin (GPFX) every day from a day after tracheal inoculation. Results: While all emphysematous mice without GPFX treatment died within 8 days, all emphysematous mice with GPFX treatment survived. Seventy two hrs after infection, serum levels of tumor necrosis factor alpha, chemokine (C-X-C motif) ligand 1, and CXCL2 (Macrophage inflammatory protein-2) in emphysematous mice with antibiotic therapy were significantly lower than those without therapy. Conclusions: Thus, the early intervention using a respiratory quinolone antibiotic prevents emphysematous mice with pneumonia from severe systemic inflammation, and rescues these mice from death. These results suggest that early intervention using a respiratory quinolone may improve the outcome of the exacerbated COPD patients

AC resistivity of d-wave ceramic superconductors

We model d-wave ceramic superconductors with a three-dimensional lattice of randomly distributed $\pi$ Josephson junctions with finite self-inductance. The linear and nonlinear ac resistivity of the d-wave ceramic superconductors is obtained as function of temperature by solving the corresponding Langevin dynamical equations. We find that the linear ac resistivity remains finite at the temperature $T_p$ where the third harmonics of resistivity has a peak. The current amplitude dependence of the nonlinear resistivity at the peak position is found to be a power law. These results agree qualitatively with experiments. We also show that the peak of the nonlinear resistivity is related to the onset of the paramagnetic Meissner effect which occurs at the crossover temperature $T_p$, which is above the chiral glass transition temperature $T_{cg}$.Comment: 7 eps figures, Phys. Rev. B (in press

Discovery of a new dwarf nova, TSS J022216.4+412259.9: WZ Sge-type dwarf novae breaking the shortest superhump period record

We report on the time-resolved CCD photometry of a newly discovered variable star, TSS J022216.4+412259.9 during the outburst in 2005 November-December brightening. The obtained light curves unambiguously showed 0.2-0.3 mag modulations, which we confirmed to be the superhump observed among SU UMa-type dwarf novae. We also performed a period search for the data obtained during the outburst plateau phase, and revealed the existence of the two periodicities: 0.054868(98) days for the first two nights and 0.055544(26) days for the following plateau phase. This bi-periodicity is hardly observed in usual SU UMa-type dwarf novae, but characteristic of WZ Sge-type stars. We undoubtedly detected a rebrightening in the post-outburst stage, which is typical of short-period SU UMa-type dwarf novae including WZ Sge-type stars. These observations suggests that TSS J022216.4+412259.9 may be a new WZ Sge stars breaking the shortest superhump period of 0.05648 days for V592 Her among this class with a known superhump period so far.Comment: 5 pages, 6 figures, accepted for PASJ lette