Mobile Hardware-Information System for Neuro-Electrostimulation

The article describes organizational principles of the mobile hardware-informational system based on the multifactorial neuro-electrostimulation device. The system is implemented with two blocks: the first block forms the spatially distributed field of low-frequency monopolar current pulses between two multielement electrodes in the neck region. Functions of the second block, specialized control interface, are performed by a smartphone. Information is exchanged between two blocks through a telemetric channel. The mobile hardware-informational system allows to remotely change the structure of the current pulses field, to control its biotropic characteristics and to change the targets of the stimulation. Moreover, it provides patient data collection and processing, as well as access to the specialized databases. The basic circuit solutions for the neuro-electrostimulation device, implemented by means of microcontroller and elements of high-level hardware integration, are described. The prospects of artificial intelligence and machine learning application for treatment process management are discussed. © 2018 Vladimir S. Kublanov et al.)is study was supported by the Act 211 of the Government of the Russian Federation (contract no. 02.A03.21.0006) and was funded by RFBR (project no, 18-29-02052)

Using the dynamic mapping of the microwave brain radiation for functional studies

In this study, organizational principles of the radiophysical complex are proposed for simultaneous measurements of the brightness temperature fluctuations of the human brain and parameters of the autonomic nervous system. A new structure of the medical microwave radiothermograph is suggested based on the parametric compensation of losses in the circuit elements of the thermobalance. The aim of this article is to justify the structural organization of the radiophysical complex for the recording and joint real-time analysis of processes of the microwave radiation formation in the brain tissue and characteristics of the autonomic nervous system. Description of the radiophysical complex MRTHR with realization of these principles is presented. The peculiarity of the proposed radiophysical complex is in passive elements that do not contain electronic nodes and blocks and are inside the shielded cabin. In order to increase the accuracy of the brightness temperature of the deep brain structures measurement in the radiophysical complex a new structure is implemented. This structure of the medical microwave radiothermograph is based on the parametric compensation of losses in the circuit elements of the thermobalance

Case study of interrelation between brain-computer interface based multimodal metric and heart rate variability

The Brain-Computer Interface (BCI) can be used for evaluation of the state of individuals during everyday routines. As shown in previous works, there is a relationship between the BCI multimodal metric with functional states of human. We have used power of Theta, Alpha, Beta low and Beta high electroencephalography rhythms and head motion data signals for multimodal metric. Heart Rate Variability (HRV) is common medical method for functional state assessment. In this paper the results of interrelation estimation between multimodal metric and HRV are shown. We used Pearson correlation coefficient (PCC) for estimates of interrelation between multimodal metric and HRV. It was found, the best results for estimates of parasympathetic part of the autonomic nervous system and suprasegmental regulation HRV have value of PCC more then critical value for Pearson correlation. © 2019 by SCITEPRESS - Science and Technology Publications, Lda. All rights reserved.The work was supported by Act 211 Government of the Russian Federation, contract № 02.A03.21.0006

Observation of time quasicrystal and its transition to superfluid time crystal

We report experimental realization of a quantum time quasicrystal, and its transformation to a quantum time crystal. We study Bose-Einstein condensation of magnons, associated with coherent spin precession, created in a flexible trap in superfluid $^3$He-B. Under a periodic drive with an oscillating magnetic field, the coherent spin precession is stabilized at a frequency smaller than that of the drive, demonstrating spontaneous breaking of discrete time translation symmetry. The induced precession frequency is incommensurate with the drive, and hence the obtained state is a time quasicrystal. When the drive is turned off, the self-sustained coherent precession lives a macroscopically-long time, now representing a time crystal with broken symmetry with respect to continuous time translations. Additionally, the magnon condensate manifests spin superfluidity, justifying calling the obtained state a time supersolid or a time super-crystal

Heart rate variabilitymeasurement using a smartphone camera

In this article authors conduct a research targeting a possibilities of heart rate variability (HRV) measurement using smartphone camera. Factors strongly influencing the photoplethysmogram signal registered with smartphone camera are described. An algorithm for HRV signal measurement using photoplethysmogram is proposed. In order to perform simultaneous photoplethysmogram and electrocardiogram registration an experiment has been settled. Comparative analysis between HRV signals measured from photoplethysmogram and electrocardiogram is performed. Relying on such analysis quantitative estimates of quality of HRV signal measured from photoplethysmogram have been acquired. Demonstrated that proposed method has high accuracy. Results of this research will be used while developing an application that is capable of processing HRV signals in real time mode.В статье представлены результаты исследования возможности измерения вариабельности сердечного ритма (ВСР) при помощи камеры смартфона. Рассмотрены факторы, оказывающие сильное влияние на сигнал при регистрации фотоплетизмограммы с использованием камеры смартфона. Предложен алгоритм измерения сигнала ВСР по данным фотоплетизмограммы позволяет существенно уменьшить влияние описанных факторов, искажающих сигнал. Поставлен эксперимент, в ходе которого производилась одновременная регистрация фотоплетизмограммы (ФПГ) с использованием камеры смартфона и специального разработанного программного обеспечения, и электрокардиограммы (ЭКГ) с использованием электроэнцефалографа-анализатора. Проведен сравнительный анализ полученных сигналов ВСР ФПГ с данными измерений ВСР ЭКГ. По результатам сравнительного анализа приведены количественные оценки качества получаемого сигнала ВСР ФПГ. Показано, что предложенный алгоритм обработки ВСР ФПГ имеет высокую точность. Результаты исследования будут использованы при создании приложения, способного регистрировать и обрабатывать сигналы ВСР ФПГ в режиме реального времени

Preliminary study of video-based respiratory rate assessment

This paper presents the results of comparative study in physiological monitoring of human respiration rate between electrocardiography-based (ECG) method and video-based method of chest motion detection. The study involved 4 subjects aged from 30 to 70 years. During the study each subject lied on back. Total duration of the study conduct 1.5 hours. The results show that video-based and ECG-based respiration monitoring methods shows similar average respiration rate values. The outcome of the present work incites that video-based respiration assessment can be used as alternative or additional method of human respiration monitoring or diagnosingВ работе представлены результаты сравнительного анализа определения средней частоты дыхания человека полученной по данным сигнала электрокардиограммы (ЭКГ) и видеоизображений движений грудной клетки. В исследовании приняло участие 4 человека в возрасте от 30 до 70 лет. В ходе исследования испытуемые лежали на спине. Суммарная длительность исследований составила 1,5 часа. Показано, что оценки средней частоты дыхания по данным видеоизображений сопоставимы с оценками получаемыми по данным ЭКГ. Таким образом, метод определения дыхания по видеоизображениям может быть использован как альтернативный или дополнительный способ мониторинга или диагностики дыхания человека

THE EVALUATION OF HEART RATE VARIABILITY SIGNALS USING MONOFRACTAL ANALYSIS

The comparison analysis of Hurst exponent indicators for short-term series of heart rate variability of four patients groups by different methods is presented. The consistent results obtained by both methods of estimation are shown. Change of the Hurst exponent corresponds to the dynamics of patient treatment

“ARMAN” archaea depend on association with euryarchaeal host in culture and in situ

AbstractIntriguing, yet uncultured ‘ARMAN’-like archaea are metabolically dependent on other members of the microbial community. It remains uncertain though which hosts they rely upon, and, because of the lack of complete genomes, to what extent. Here, we report the co-culturing of ARMAN-2-related organism, Mia14, with Cuniculiplasma divulgatum PM4 during the isolation of this strain from acidic streamer in Parys Mountain (Isle of Anglesey, UK). Mia14 is highly enriched in the binary culture (ca. 10% genomic reads) and its ungapped 0.95 Mbp genome points at severe voids in central metabolic pathways, indicating dependence on the host, C. divulgatum PM4. Analysis of C. divulgatum isolates from different sites and shotgun sequence data of Parys Mountain samples suggests an extensive genetic exchange between Mia14 and hosts in situ. Within the subset of organisms with high-quality genomic assemblies representing the ‘DPANN’ superphylum, the Mia14 lineage has had the largest gene flux, with dozens of genes gained that are implicated in the host interaction.</jats:p