645 research outputs found

    ID1: MODELLING THE COSTS AND EFFECTS OF CMV MANAGEMENT STRATEGIES IN TRANSPLANT RECIPIENTS AS A SUPPORT FOR CURRENT AND FUTURE DECISION-MAKING

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    Dislocation patterns and the similitude principle: 2.5D mesoscale simulations

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    During plastic flow of crystalline solids, dislocations self-organize in the form of patterns, with a wavelength that is inversely proportional to stress. After four decades of investigations, the origin of this property is still under discussion. We show that dislocation patterns verifying the principle of similitude can be obtained from dynamics simulations of double slip. These patterns are formed in the presence of long- and short-range interactions, but they are not significantly modified when only short-range interactions are present. This new insight into dislocation patterning phenomena has important implications regarding current models

    A Framework for Developing Multiyear Conferences on Current Societal Issues

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    This article describes how Extension professionals and university faculty collaborated on the planning, implementation, and evaluation of a conference to address a key societal issue. Needs assessment and evaluation results are presented as well as an explanation of how results were used in planning future conferences. With limited Extension budgets and personnel, partnering among Extension specialists, university faculty, and experts in relevant topics is a valuable and efficient way to provide the most impact for a community. Developing multiyear conferences to address significant societal issues may be a new way to increase Extension\u27s impact

    Missing physics in stick-slip dynamics of a model for peeling of an adhesive tape

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    It is now known that the equations of motion for the contact point during peeling of an adhesive tape mounted on a roll introduced earlier are singular and do not support dynamical jumps across the two stable branches of the peel force function. By including the kinetic energy of the tape in the Lagrangian, we derive equations of motion that support stick-slip jumps as a natural consequence of the inherent dynamics. In the low mass limit, these equations reproduce solutions obtained using a differential-algebraic algorithm introduced for the earlier equations. Our analysis also shows that mass of the ribbon has a strong influence on the nature of the dynamics.Comment: Accepted for publication in Phys. Rev. E (Rapid Communication

    Relaxation oscillations and negative strain rate sensitivity in the Portevin - Le Chatelier effect

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    A characteristic feature of the Portevin - Le Chatelier effect or the jerky flow is the stick-slip nature of stress-strain curves which is believed to result from the negative strain rate dependence of the flow stress. The latter is assumed to result from the competition of a few relevant time scales controlling the dynamics of jerky flow. We address the issue of time scales and its connection to the negative strain rate sensitivity of the flow stress within the framework of a model for the jerky flow which is known to reproduce several experimentally observed features including the negative strain rate sensitivity of the flow stress. We attempt to understand the above issues by analyzing the geometry of the slow manifold underlying the relaxational oscillations in the model. We show that the nature of the relaxational oscillations is a result of the atypical bent geometry of the slow manifold. The analysis of the slow manifold structure helps us to understand the time scales operating in different regions of the slow manifold. Using this information we are able to establish connection with the strain rate sensitivity of the flow stress. The analysis also helps us to provide a proper dynamical interpretation for the negative branch of the strain rate sensitivity.Comment: 7 figures, To appear in Phys. Rev.

    The hidden order behind jerky flow

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    Jerky flow, or the Portevin-Le Chatelier effect, is investigated at room temperature by applying statistical, multifractal and dynamical analyses to the unstable plastic flow of polycrystalline Al-Mg alloys with different initial microstructures. It is shown that a chaotic regime is found at medium strain rates, whereas a self-organized critical dynamics is observed at high strain rates. The cross-over between these two regimes is signified by a large spread in the multifractal spectrum. Possible physical mechanisms leading to this wealth of patterning behavior and their dependence on the strain rate and the initial microstructure are discussed

    Glucoregulatory Consequences and Cardiorespiratory Parameters in Rats Exposed to Chronic–Intermittent Hypoxia: Effects of the Duration of Exposure and Losartan

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    Background: Obstructive sleep apnea (OSA) is associated with glucose intolerance. Both chronic sleep disruption and recurrent blood oxygen desaturations (chronic–intermittent hypoxia, CIH) may cause, or exacerbate, metabolic derangements. Methods: To assess the impact of CIH alone, without accompanying upper airway obstructions, on the counter-regulatory response to glucose load and cardiorespiratory parameters, we exposed adult male Sprague-Dawley rats to CIH or sham room air exchanges for 10 h/day for 7, 21, or 35 days and then, 1 day after conclusion of CIH exposure, conducted intravenous glucose-tolerance tests (ivgtt) under urethane anesthesia. Additional rats underwent 35 days of CIH followed by 35 days of regular housing, or had 35 day-long CIH exposure combined with daily administration of the type 1 angiotensin II receptor antagonist, losartan (15 mg/kg, p.o.), and then were also subjected to ivgtt. Results: Compared with the corresponding control groups, CIH rats had progressively reduced glucose-stimulated insulin release and impaired glucose clearance, only mildly elevated heart rate and/or arterial blood pressure and slightly reduced respiratory rate. The differences in insulin release between the CIH and sham-treated rats disappeared in the rats normally housed for 35 days after 35 days of CIH/sham exposure. The losartan-treated rats had improved insulin sensitivity, with no evidence of suppressed insulin release in the CIH group. Conclusion: In adult rats, the glucose-stimulated insulin release is gradually suppressed with the duration of exposure to CIH, but the effect is reversible. Elimination of the detrimental effect of CIH on insulin release by losartan suggests that CIH disrupts glucoregulation through angiotensin/catecholaminergic pathways. Accordingly, treatment with continuous positive airway pressure may ameliorate pre-diabetic conditions in OSA patients, in part, by reducing sympathoexcitatory effects of recurrent nocturnal hypoxia

    Modelización de las inestabilidades en la deformación plástica de monocristales de circona estabilizada con itria (YCSZ)

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    En este trabajo se presenta un modelo para explicar las inestabilidades dinámicas observadas durante la deformación plástica a alta temperatura de monocristales de circona estabilizada con itria, (YCSZ, yttria cubic stabilized zirconia) con alto contenido en itria. El modelo se basa en el fenómeno Portevin-Le Chatelier (PLC), que consiste en episodios sucesivos de anclaje y desanclaje de dislocaciones cuando éstas se mueven con una velocidad del mismo orden que los defectos que obstaculizan su movimiento. La evaluación numérica de los parámetros implicados en el modelo muestra que las inestabilidades plásticas son totalmente compatibles con el efecto Portevin- Le Chatelie

    High order amplitude equation for steps on creep curve

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    We consider a model proposed by one of the authors for a type of plastic instability found in creep experiments which reproduces a number of experimentally observed features. The model consists of three coupled non-linear differential equations describing the evolution of three types of dislocations. The transition to the instability has been shown to be via Hopf bifurcation leading to limit cycle solutions with respect to physically relevant drive parameters. Here we use reductive perturbative method to extract an amplitude equation of up to seventh order to obtain an approximate analytic expression for the order parameter. The analysis also enables us to obtain the bifurcation (phase) diagram of the instability. We find that while supercritical bifurcation dominates the major part of the instability region, subcritical bifurcation gradually takes over at one end of the region. These results are compared with the known experimental results. Approximate analytic expressions for the limit cycles for different types of bifurcations are shown to agree with their corresponding numerical solutions of the equations describing the model. The analysis also shows that high order nonlinearities are important in the problem. This approach further allows us to map the theoretical parameters to the experimentally observed macroscopic quantities.Comment: LaTex file and eps figures; Communicated to Phys. Rev.
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