SYNTHESIS AND CHARACTERIZATION OF NEW COUMARIN DERIVATIVES CONTAINING VARIOUS MOIETIES WITH ANTIBACTERIAL ACTIVITIES

Objective: The purpose of this research is to evaluate the antibacterial activity of different moieties (Schiff bases, chalcones, hydrazones and hydrazinyl thiazole) derivatives, inserted at carbon 8 of 7-hydroxy-4-methyl coumarin, using in vitro, serial broth dilution method.Methods: A series of new coumarin derivatives, including (Schiff bases, chalcones, hydrazones and hydrazinyl thiazole), were prepared from 7-hydroxy-4-methyl coumarin, by insertion of the formyl group, at carbon number 8 using Duff reaction. The structure of the new synthesized derivatives elucidated and confirmed utilizing the corresponding analytical and spectroscopic data; including FT-IR, 13C-NMR, and mass spectroscopy. All new coumarin derivatives have been screened for their preliminary antibacterial activity, by serial broth dilution method against two Gram-positive bacteria (Staphylococcus epidermidis and Staphylococcus hemolyticus) and two Gram-negative bacteria (Escherichia coli and Klebsiella pneumoniae).Results: All the synthesized compounds have been found to exhibit considerable antibacterial activity in vitro. Among all the derivatives, compound (5a), showed the highest rate of inhibition, against (Escherichia coli), while compound (6a), showed the greatest anti-bacterial activity against (Staphylococcus hemolyticus), each with minimum inhibitory concentration of (25µg/ml), and the highest MIC of 200 µg/ml for compound 2, against. Klebsiella pneumoniae.Conclusion: Our results displayed a substantial preliminary antibacterial activity of the new coumarin moieties, especially some hydrazones and chalcones at C8 of the coumarin nucleus, against Gram-positive and a Gram-negative bacteria with distinguished MIC.Â

A micro-capacitive pressure sensor design and modelling

Abstract. Measuring air pressure using a capacitive pressure sensor is a robust and precise technique. In addition, a system that employs such transducers lies within the low power consumption applications such as wireless sensor nodes. In this article a high sensitivity with an elliptical diaphragm capacitive pressure sensor is proposed. This design was compared with a circular diaphragm in terms of thermal stresses and pressure and temperature sensitivity. The proposed sensor is targeted for tyre pressure monitoring system application. Altering the overlapping area between the capacitor plates by decreasing the effective capacitance area to improve the overall sensitivity of the sensor (ΔC ∕ C), temperature sensitivity, and built-up stresses is also examined in this article. Theoretical analysis and finite element analysis (FEA) were employed to study pressure and temperature effects on the behaviour of the proposed capacitive pressure sensor. A MEMS (micro electro-mechanical systems) manufacturing processing plan for the proposed capacitive sensor is presented. An extra-low power short-range wireless read-out circuit suited for energy harvesting purposes is presented in this article. The developed read-out circuitry was tested in terms of sensitivity and transmission range.</jats:p

Flexible Bond Wire Capacitive Strain Sensor for Vehicle Tyres

The safety of the driving experience and manoeuvrability of a vehicle can be improved by detecting the strain in tyres. To measure strain accurately in rubber, the strain sensor needs to be flexible so that it does not deform the medium that it is measuring. In this work, a novel flexible bond wire capacitive strain sensor for measuring the strain in tyres is developed, fabricated and calibrated. An array of 25 micron diameter wire bonds in an approximately 8 mm × 8 mm area is built to create an interdigitated structure, which consists of 50 wire loops resulting in 49 capacitor pairs in parallel. Laser machining was used to pattern copper on a flexible printed circuit board PCB to make the bond pads for the wire attachment. The wire array was finally packaged and embedded in polydimethylsiloxane (PDMS), which acts as the structural material that is strained. The capacitance of the device is in a linear like relationship with respect to the strain, which can measure the strain up to at least ±60,000 micro-strain (±6%) with a resolution of ~132 micro-strain (0.013%). In-tyre testing under static loading has shown the ability of the sensor to measure large tyre strains. The technology used for sensor fabrication lends itself to mass production and so the design is considered to be consistent with low cost commercialisable strain sensing technology

Intelligent tyre technologies

This thesis reports an investigation about range of intelligent tyre technologies. A piezoelectric transducer was utilized to measure tyre inner liner strain in the longitudinal direction. Tyre driving condition can be recognized from different tyre strain pattern data which is collected from the piezoelectric transducers. Tyre load, slip angle, and rolling speed can be identified from the tyre strain pattern throughout the tyre contact patch area strain pattern. A novel circumferential four-chamber tyre concept was designed, manufactured and tested in this study. These four-chamber prototypes can have independent inflation pressure in each chamber to provide wide range of tyre behavior which is suitable for different road surfaces and driving conditions. The multi-chamber tyre has a range of modes to accommodate urban and motorway driving for rolling resistance and grip control. A multi-chamber tyre finite element model using ABAQUS software was developed from a conventional tyre model to design and validate these tyre prototypes. These multi-chamber tyre prototypes were manufactured with the assistance of Fusion Innovations Ltd and tested in the University of Birmingham tyre test rig. Finally, a shape memory alloy valve design was investigated to control the air flow in the multi-chamber tyre

Fatigue Characteristics and Numerical Modelling Prosthetic for Chopart Amputation

This research is looking for three laminated composite material groups. These three groups were utilized in experimental investigation to find their mechanical properties. These properties have been used to design and manufacture a socket for a partial foot prosthesis using an ANSYS model. This socket was manufactured with a vacuum pressure device to improve its properties. The socket composite material was tested for tensile and fatigue properties; then, its results were used in the ANSYS model. The composite material matrix was laminated in an 80 : 20 ratio, and there were three types of reinforcement lamination material (Perlon, glass fiber, and carbon fiber). The mechanical property results of these tests were found as follows: using only-Perlon reinforcement, the properties are σy=33.6 MPa, σult=35.6 MPa, and modulus of elasticity=1.03 GPa; using (3Perlon +2carbon fiber +3perlon) layers, the properties were σy=65.5 MPa, σult=92.5 MPa, and modulus of elasticity=1.99 GPa; and using (3Perlon + 2 glass fiber + 3perlon) layers, the results were σy=40 MPa, σult=46.6 MPa, and modulus of elasticity=1.4 GPa. The ANSYS model used the boundary condition from the measured contact pressure between the socket and the patient’s stump. The MatScan (F-socket) pressure sensor utilized these interface pressure measurements. The maximum values for the pressure were found as follows: 190 kPa and 164 kPa, which are recorded in the posterior and lateral locations, respectively. The calculated factor of safety for the prosthesis that has been made from a selected composite material with the following layers (3 Perlon+2 carbon fiber+3 Perlon) is 1.037 which is safe for design prosthetic applications. From this study, more prosthetic designs can be modelled and manufactured using this approach. Prosthetics and orthotics are usually custom-made for each patient according to its specific requirements. So, it will be very helpful to find a procedure to analyze the prosthetics before manufacturing it