Unveiling the Noncanonical Activation Mechanism of Cdks: Insights From Recent Structural Studies

The Cyclin-dependent kinases (CDKs) play crucial roles in a range of essential cellular processes. While the classical two-step activation mechanism is generally applicable to cell cycle-related CDKs, both CDK7 and CDK8, involved in transcriptional regulation, adopt distinct mechanisms for kinase activation. In both cases, binding to their respective cyclin partners results in only partial activity, while their full activation requires the presence of an additional subunit. Recent structural studies of these two noncanonical kinases have provided unprecedented insights into their activation mechanisms, enabling us to understand how the third subunit coordinates the T-loop stabilization and enhances kinase activity. In this review, we summarize the structure and function of CDK7 and CDK8 within their respective functional complexes, while also describing their noncanonical activation mechanisms. These insights open new avenues for targeted drug discovery and potential therapeutic interventions in various diseases related to CDK7 and CDK8

An UM-based silhouette-crease edge enhancement for noisy images

[[abstract]]This paper presents an improved unsharp masking (UM) technique that enhances the quality and suppresses noises for the images acquired from a noisy environment such as taken during night time. Our approach employs noise smoothing and the idea that important edges should be enhanced more than minor edges. Edges are classified as silhouette and crease edges (major and minor edges) according to their lengths. An adaptive weighting method is used to enhance the edges. In this way, the major edges (silhouette) are sharpened more than minor edges (crease). The proposed method is examined on night images as well as noisy images. It is also compared to existing UM-based methods with satisfying results.[[notice]]補正完

Polarization and decoherence in a two-component Bose-Einstein Condensate

We theoretically investigate polarization properties of a two-component Bose-Einstein condensate (BEC) and influence of decoherence induced by environment on BEC polarization through introducing four BEC Stokes operators which are quantum analog of the classical Stokes parameters for a light field. BEC polarization states can be geometrically described by a Poincar\'{e} sphere defined by expectation values of BEC Stokes operators. Without decoherence, it is shown that nonlinear inter-atomic interactions in the BEC induce periodic polarization oscillations whose periods depend on the difference between self-interaction in each component and inter-component interaction strengths. In particular, when inter-atomic nonlinear self-interaction in each BEC component equals inter-component nonlinear interaction, Stokes vector associated with Stokes operators precesses around a fixed axis in the dynamic evolution of the BEC. The value of the processing frequency is determined by the strength of the linear coupling between two components of the BEC. When decoherence is involved, we find each component of the Stokes vector decays which implies that decoherence depolarizes the BEC.Comment: 10 pages, 2 figure

Holographic fermions in charged Lifshitz theory

We investigate the properties of holographic fermions in charged Lifshitz black holes at finite temperature through the AdS/CFT correspondence. In the charged Lifshitz background with the dynamical exponent $z=2$, we find that the dispersion relation is linear. The scaling behavior of the imaginal part of the Green function relative to $k_{\perp}=k-k_F$ is also discussed. We find, although the system has linear dispersion relation and quadratic quasi-particle width, it does not satisfy Luttinger's theorem. We also find that the variation of the scaling parameters $\alpha$ and $\beta$ is small as the charge $q$ varies. Furthermore, we also discuss the effect of the dynamical exponent $z$ by considering the cases $z=4$ and $z=6$ and show that $ImG_{ii}$ become smooth when the dynamical exponent $z$ increases.Comment: 1+16pages, many figures, published versio

Awareness, knowledge and acceptance of community on a non-communicable disease intervention – findings from the “Healthy Community, Developed Nation” (KOSPEN) in the Southern Zone of Peninsular Malaysia

Introduction Community-based health promotion programme has been recognised to reduce modifiable lifestyle risk behaviours for non-communicable diseases. The aim of this study was to evaluate the proportion of the awareness, knowledge and acceptance of a community-based intervention programme, “Komuniti Sihat, Pembina Negara“ (KOSPEN) (Healthy Community, Developed Nation). Methods This cross-sectional study employed a two-stage proportionate sampling method to select a representative sample of communities in the Southern states of Peninsular Malaysia, Negeri Sembilan, Malacca, and Johor. Face-to-face interviews by trained research assistants using pre-validated questionnaires was the study tool applied. Results The study revealed that approximately two thirds of respondents were aware of the KOSPEN programme (65.5%) and almost half (45.4%) of them were involved in the health promotion activities, namely health screenings (84.8%), health talks (66.4%), and providing plain water in formal occasion (52.9%). About two thirds and one-quarter of them have a very good (73.4%) and good (24.1%) general view on this programme. Four out of ten respondents faced difficulties joining the activities. Lack of time (83.0%) was reported as the main barrier. Conclusions The KOSPEN programme in overall was moderately accepted by the community. However, the need for future improvement has to be highlighted in order to enhance the involvement and participation of the communities