Water, Tourists, and Community Equity: a scenario analysis for Destinations in the United States

Water resource management has long been a vital component of sustainable development. At destinations where tourism is among the largest economic sectors, a remarkable increase in water consumption could draw challenges to environmental and social assets. The complex relationship between tourism, water and community has yet to be explored. This study attempts to explore the complex nexus between tourism, water resources, and destination community. It builds on the assumption of various climate change scenarios to impacts and reactions to stakeholders within the nexus. This study aims to answer (1) who are the water stress and conflict generators at the selected destinations? (2) What are the geo-political and policy discourses on water resource rights that shape the tourists\u27 visitation, spending, and behaviors and the local tourism industry? And (3) How could destination policymakers set future water management structures that equally address the water right in fulfilling the needs of multiple stakeholders

Synergistic actions between the SRP RNA and translating ribosome allow efficient delivery of the correct cargos during cotranslational protein targeting

During cotranslational protein targeting by the Signal Recognition Particle (SRP), the correct cargo accelerates stable complex assembly between the SRP and SRP receptor (FtsY) by several orders of magnitude, thus enabling rapid and faithful cargo delivery to the target membrane. The molecular mechanism underlying this cargo-induced rate acceleration has been unclear. Here we show that the SRP RNA allows assembly of the SRP–FtsY complex to be specifically stimulated by a correct cargo, and, reciprocally, a correct cargo enables the SRP RNA to optimize its electrostatic interactions with FtsY. These results combined with recent structural work led us to suggest a “conformational selection” model that explains the synergistic action of the SRP RNA with the cargo in accelerating complex assembly. In addition to its previously proposed role in preventing the premature dissociation of SRP and FtsY, we found that the SRP RNA also plays an active role in ensuring the formation of productive assembly intermediates, thus guiding the SRP and FtsY through the most efficient pathway of assembly

Signal Recognition Particle: An Essential Protein-Targeting Machine

The signal recognition particle (SRP) and its receptor compose a universally conserved and essential cellular machinery that couples the synthesis of nascent proteins to their proper membrane localization. The past decade has witnessed an explosion in in-depth mechanistic investigations of this targeting machine at increasingly higher resolutions. In this review, we summarize recent work that elucidates how the SRP and SRP receptor interact with the cargo protein and the target membrane, respectively, and how these interactions are coupled to a novel GTPase cycle in the SRP·SRP receptor complex to provide the driving force and enhance the fidelity of this fundamental cellular pathway. We also discuss emerging frontiers in which important questions remain to be addressed