Compassion and Merit in Early Buddhism with the Focus on the Aṅguttara Nikāya and the Ekottarika Āgama

Of the four Nikāyas in Pali and the four Āgamas in Chinese, the numerical collections, i.e. the Aṅguttara Nikāya and the Ekottarika Āgama, are the most adaptable and considerate of individual needs according to ancient Indian/Chinese and modern American monks. Therefore, these two collections contain a considerable proportion of suttas/sūtras that are closely connected with the notion of compassion (karuṇā/anukampā). These two collections include many suttas addressed to Buddhists dealing with the ethical and spiritual concerns of life within the world, and thus involves the issues of merit (puñña). In this study I have illustrated the significant but often underestimated position of compassion with merit in early Buddhist doctrine. The soteriological function of compassion associated with merit is expounded in the early suttas/sūtras, particularly those in the Aṅguttara Nikāya and the Ekottarika Āgama. On the other hand, many discourses in these two collections reify great compassion by extending Buddhist concern from monastics to the laity, caring for all beings’ worldly welfare based on an ethical system of merit

Some reflections on translating the pali texts: Literary conventions, Buddhist thought, cultural background and textual history

For over a century many Buddhist texts in Pali have been translated into English, the four main Nikāyas at least twice. Significant improvements have been made in regard to English translations of Pali texts. This paper provides five case studies that illustrate the problems and complexities involved in translating Pali texts. Examples are taken from four suttas of the Aṅguttara Nikāya. Various issues are addressed using textual and contextualised analyses. I attempt to offer solutions to some problems related to translating the Pali through different approaches, including style, philology, history, Buddhist thought and inter-religious relation

Is mindfulness Buddhist? (and why it matters).

Modern exponents of mindfulness meditation promote the therapeutic effects of "bare attention"--a sort of non-judgmental, non-discursive attending to the moment-to-moment flow of consciousness. This approach to Buddhist meditation can be traced to Burmese Buddhist reform movements of the first half of the 20th century, and is arguably at odds with more traditional Theravāda Buddhist doctrine and meditative practices. But the cultivation of present-centered awareness is not without precedent in Buddhist history; similar innovations arose in medieval Chinese Zen (Chan) and Tibetan Dzogchen. These movements have several things in common. In each case the reforms were, in part, attempts to render Buddhist practice and insight accessible to laypersons unfamiliar with Buddhist philosophy and/or unwilling to adopt a renunciatory lifestyle. In addition, these movements all promised astonishingly quick results. And finally, the innovations in practice were met with suspicion and criticism from traditional Buddhist quarters. Those interested in the therapeutic effects of mindfulness and bare attention are often not aware of the existence, much less the content, of the controversies surrounding these practices in Asian Buddhist history

Incorporating mindfulness: questioning capitalism

This paper engages with Buddhist critiques of capitalism and consumerism; and it challenges the capitalist appropriations of Buddhist techniques. We show how Buddhist modernism and Marxism/socialism can align, and how Engaged Buddhism spawns communalism and socially revolutionary impulses for sustainability and ecological responsibility within the framework of Buddhist thought and mindfulness traditions. Our case study of the Thai Asoke community exemplifies Buddhist communal mindfulness-in-action, explores successes and idiosyncrasies, and shows how communal principles can operate in such work-based communities

The practice of mindfulness (Sati) in early Buddhism

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

A novel flowchart to predict mortality and analyse effectiveness of routinely used pharmacological regimens in paraquat poisoning

International audienc

An Atypical F-Actin Capping Protein Modulates Cytoskeleton Behaviors Crucial for Trichomonas vaginalis Colonization

ABSTRACT Cytoadherence and migration are crucial for pathogens to establish colonization in the host. In contrast to a nonadherent isolate of Trichomonas vaginalis, an adherent one expresses more actin-related machinery proteins with more active flagellate-amoeboid morphogenesis, amoeba migration, and cytoadherence, activities that were abrogated by an actin assembly blocker. By immunoprecipitation coupled with label-free quantitative proteomics, an F-actin capping protein (T. vaginalis F-actin capping protein subunit α [TvFACPα]) was identified from the actin-centric interactome. His-TvFACPα was detected at the barbed end of a growing F-actin filament, which inhibited elongation and possessed atypical activity in binding G-actin in in vitro assays. TvFACPα partially colocalized with F-actin at the parasite pseudopod protrusion and formed a protein complex with α-actin through its C-terminal domain. Meanwhile, TvFACPα overexpression suppressed F-actin polymerization, amoeboid morphogenesis, and cytoadherence in this parasite. Ser2 phosphorylation of TvFACPα enriched in the amoeboid stage of adhered trophozoites was reduced by a casein kinase II (CKII) inhibitor. Site-directed mutagenesis and CKII inhibitor treatment revealed that Ser2 phosphorylation acts as a switching signal to alter TvFACPα actin-binding activity and the consequent actin cytoskeleton behaviors. Through CKII signaling, TvFACPα also controls the conversion of adherent trophozoites from amoeboid migration to the flagellate form with axonemal motility. Together, CKII-dependent Ser2 phosphorylation regulates TvFACPα binding to actin to fine-tune cytoskeleton dynamics and drive crucial behaviors underlying host colonization by T. vaginalis. IMPORTANCE Trichomoniasis is one of the most prevalent nonviral sexually transmitted diseases. T. vaginalis cytoadherence to urogenital epithelium cells is the first step in the colonization of the host. However, studies on the mechanisms of cytoadherence have focused mainly on the role of adhesion molecules, and their effects are limited when analyzed by loss- or gain-of-function assays. This study proposes an extra pathway in which the actin cytoskeleton mediated by a capping protein α-subunit may play roles in parasite morphogenesis, cytoadherence, and motility, which are crucial for colonization. Once the origin of the cytoskeleton dynamics could be manipulated, the consequent activities would be controlled as well. This mechanism may provide new potential therapeutic targets to impair this parasite infection and relieve the increasing impact of drug resistance on clinical and public health

Design of optimal step–stress accelerated life tests under progressive type I censoring with random removals

Progressive type I censoring with random removal (PCRR), Step–stress, Accelerated life testing, Asymptotic variance, Variance (V)-optimality, Determinant (D)-optimality,