The effect of hemodynamically-guided hypotensive therapy in one-year observation: Randomized, prospective and controlled trial (FINEPATH study)

Background: The use of impedance cardiography (ICG) revealed to provide beneficial blood pressure (BP) lowering effect. However, the follow-up in previous trials was short and brachial BP was the only evaluated hemodynamic variable. Thus, we aimed to estimate the influence of ICG-guided therapy on brachial and central BP, impedance-derived hemodynamic profile and echocardiographic features after 12 months in a randomized, prospective and controlled trial (NCT01996085). Methods: One hundred and forty-four hypertensives were randomly assigned to groups of empiric (GE) and ICG-guided therapy (HD). Office BP, ambulatory BP monitoring, central BP and echocardiography (left ventricular hypertrophy and diastolic function assessment) were performed before and after 12 months of treatment. Results: Blood pressure reduction was higher in HD (office BP: 21.8/14.1 vs. 19.9/11.8 mm Hg; mean 24-h BP: 19.0/10.9 vs. 14.4/9.2 mm Hg). However, the only statistically significant differences were: percentage of patients achieving BP reduction of minimum 20 mm Hg for of­fice diastolic BP (27.3% vs. 12.1%; p = 0.034) and mean 24-h systolic BP (49.1% vs. 27.3%; p = 0.013). More pronounced improvement in the left ventricular diastolic dysfunction (delta E/A 0.34 vs. 0.12, p = 0.017) was the only other beneficial hemodynamic effect. Conclusions: Beneficial BP lowering effect of hemodynamically-guided pharmacotherapy, observed previously in short-term observation, persists over time. Hemodynamic effects of such a treatment approach, especially those of prognostic value (central BP, myocardial hypertrophy), should be evaluated in further studies including patients with resistant hypertension, heart failure, diabetes mellitus and chronic kidney disease

A Catalog of Spectroscopically Confirmed White Dwarfs from the Sloan Digital Sky Survey Data Release 4

We present a catalog of 9316 spectroscopically confirmed white dwarfs from the Sloan Digital Sky Survey Data Release 4. We have selected the stars through photometric cuts and spectroscopic modeling, backed up by a set of visual inspections. Roughly 6000 of the stars are new discoveries, roughly doubling the number of spectroscopically confirmed white dwarfs. We analyze the stars by performing temperature and surface gravity fits to grids of pure hydrogen and helium atmospheres. Among the rare outliers are a set of presumed helium-core DA white dwarfs with estimated masses below 0.3 Msun, including two candidates that may be the lowest masses yet found. We also present a list of 928 hot subdwarfs.Comment: Accepted by the Astrophysical Journal Supplements, 25 pages, 24 figures, LaTeX. The electronic catalog, as well as diagnostic figures and links to the spectra, is available at http://das.sdss.org/wdcat/dr4

Risk of left atrial appendage thrombus in patients with atrial fibrillation and chronic kidney disease

Background: Atrial fibrillation (AF) and chronic kidney disease (CKD) are associated with an increased risk of ischemic stroke. The aim of this study was to compare the clinical characteristics, the incidence of left atrial appendage (LAA) thrombus and its predictors, and spontaneous echo contrast (SEC) in a population of patients with AF depending on estimated glomerular filtration rate (eGFR) values. Methods: This study included 1962 patients who underwent transesophageal echocardiographic examination (TEE) prior to cardioversion or ablation in the years 2014–2018 in three cardiac centers. Results: More than a quarter of AF patients had decreased eGFR ( < 60 mL/min/1.73 m2) and were characterized as a high-risk population, with more comorbidities, higher thromboembolic and bleeding risk compared to those with normal renal function. Oral anticoagulation (OAC) was prescribed in 97% and 93% of patients with decreased and normal eGFR, respectively, with a higher prevalence of prescribed non-vitamin K antagonist oral anticoagulants (NOACs). The incidence of LAA thrombus (24%, 9% and 4%) and SEC (25%, 25% and 19%) increases simultaneously with a decrease in eGFR ( < 30, 30–59 and > 60 mL/min/1.73 m2, respectively). Among patients prescribed reduced doses of NOAC, those with decreased eGFR were more often observed with LAA thrombus (10% vs. 2.5%). Non-paroxysmal AF, heart failure and previous bleeding were predictors of LAA thrombus, irrespective of eGFR value. CKD was the predictor of LAA thrombus in all patients including those with non-paroxysmal AF, males, without diabetes, without hypertension and with CHA2DS2-VASc < 2. Conclusions: Despite OAC, patients with concomitant AF and CKD remain at high risk for LAA thrombus formation

A Strategy for Finding Near Earth Objects with the SDSS Telescope

We present a detailed observational strategy for finding Near Earth Objects (NEOs) with the Sloan Digital Sky Survey (SDSS) telescope. We investigate strategies in normal, unbinned mode as well as binning the CCDs 2x2 or 3x3, which affects the sky coverage rate and the limiting apparent magnitude. We present results from 1 month, 3 year and 10 year simulations of such surveys. For each cadence and binning mode, we evaluate the possibility of achieving the Spaceguard goal of detecting 90% of 1 km NEOs (absolute magnitude H <= 18 for an albedo of 0.1). We find that an unbinned survey is most effective at detecting H <= 20 NEOs in our sample. However, a 3x3 binned survey reaches the Spaceguard Goal after only seven years of operation. As the proposed large survey telescopes (PanStarss; LSST) are at least 5-10 years from operation, an SDSS NEO survey could make a significant contribution to the detection and photometric characterization of the NEO population.Comment: Accepted by AJ -- 12 pages, 11 figure

The Sloan Digital Sky Survey Quasar Catalog IV. Fifth Data Release

We present the fourth edition of the Sloan Digital Sky Survey (SDSS) Quasar Catalog. The catalog contains 77,429 objects; this is an increase of over 30,000 entries since the previous edition. The catalog consists of the objects in the SDSS Fifth Data Release that have luminosities larger than M_i = -22.0 (in a cosmology with H_0 = 70 km/s/Mpc, Omega_M = 0.3, and Omega_Lambda = 0.7) have at least one emission line with FWHM larger than 1000 km/s, or have interesting/complex absorption features, are fainter than i=15.0, and have highly reliable redshifts. The area covered by the catalog is 5740 sq. deg. The quasar redshifts range from 0.08 to 5.41, with a median value of 1.48; the catalog includes 891 quasars at redshifts greater than four, of which 36 are at redshifts greater than five. Approximately half of the catalog quasars have i < 19; nearly all have i < 21. For each object the catalog presents positions accurate to better than 0.2 arcsec. rms per coordinate, five-band (ugriz) CCD-based photometry with typical accuracy of 0.03 mag, and information on the morphology and selection method. The catalog also contains basic radio, near-infrared, and X-ray emission properties of the quasars, when available, from other large-area surveys. The calibrated digital spectra cover the wavelength region 3800--9200A at a spectral resolution of ~2000. The spectra can be retrieved from the public database using the information provided in the catalog. The average SDSS colors of quasars as a function of redshift, derived from the catalog entries, are presented in tabular form. Approximately 96% of the objects in the catalog were discovered by the SDSS.Comment: 37 pages, Accepted for publication in A

Hot DB White Dwarfs from the Sloan Digital Sky Survey

We present ugriz photometry and optical spectroscopy for 28 DB and DO white dwarfs with temperatures between 28,000K and 45,000K. About 10 of these are particularly well-observed; the remainder are candidates. These are the hottest DB stars yet found, and they populate the "DB gap" between the hotter DO stars and the familiar DB stars cooler than 30,000K. Nevertheless, after carefully matching the survey volumes, we find that the ratio of DA stars to DB/DO stars is a factor of 2.5 larger at 30,000 K than at 20,000 K, suggesting that the "DB gap" is indeed deficient and that some kind of atmospheric transformation takes place in roughly 10% of DA stars as they cool from 30,000 K to 20,000 K.Comment: Accepted by the Astronomical Journal. 34 pages, 10 figures, LaTe

The Sloan Digital Sky Survey-II Supernova Survey: Search Algorithm and Follow-up Observations

The Sloan Digital Sky Survey-II Supernova Survey has identified a large number of new transient sources in a 300 sq. deg. region along the celestial equator during its first two seasons of a three-season campaign. Multi-band (ugriz) light curves were measured for most of the sources, which include solar system objects, Galactic variable stars, active galactic nuclei, supernovae (SNe), and other astronomical transients. The imaging survey is augmented by an extensive spectroscopic follow-up program to identify SNe, measure their redshifts, and study the physical conditions of the explosions and their environment through spectroscopic diagnostics. During the survey, light curves are rapidly evaluated to provide an initial photometric type of the SNe, and a selected sample of sources are targeted for spectroscopic observations. In the first two seasons, 476 sources were selected for spectroscopic observations, of which 403 were identified as SNe. For the Type Ia SNe, the main driver for the Survey, our photometric typing and targeting efficiency is 90%. Only 6% of the photometric SN Ia candidates were spectroscopically classified as non-SN Ia instead, and the remaining 4% resulted in low signal-to-noise, unclassified spectra. This paper describes the search algorithm and the software, and the real-time processing of the SDSS imaging data. We also present the details of the supernova candidate selection procedures and strategies for follow-up spectroscopic and imaging observations of the discovered sources.Comment: Accepted for publication in The Astronomical Journal (66 pages, 13 figures); typos correcte

Thirty‐Five New Pulsating DA White Dwarf Stars

We present 35 new pulsating DA (hydrogen atmosphere) white dwarf stars discovered from the Sloan Digital Sky Survey (SDSS) and the Hamburg Quasar Survey (HQS). We have acquired high-speed time series photometry of preselected DA white dwarfs with a prime focus CCD photometer on the 2.1 m telescope at McDonald Observatory over 15 months. We selected these stars on the basis of prior photometric and spectroscopic observations by the SDSS and HQS. For the homogeneous SDSS sample, we achieve a success rate of 80% for finding new variables at a detection threshold of 0.1%-0.3%. With 35 newly discovered DA variable white dwarfs, we almost double the current sample of 39

A Catalog of Spectroscopically Identified White Dwarf Stars in the First Data Release of the Sloan Digital Sky Survey

We present the full spectroscopic white dwarf and hot subdwarf sample from the SDSS first data release, DR1. We find 2551 white dwarf stars of various types, 240 hot subdwarf stars, and an additional 144 objects we have identified as uncertain white dwarf stars. Of the white dwarf stars, 1888 are non-magnetic DA types and 171, non-magnetic DBs. The remaining (492) objects consist of all different types of white dwarf stars: DO, DQ, DC, DH, DZ, hybrid stars like DAB, etc., and those with non-degenerate companions. We fit the DA and DB spectra with a grid of models to determine the Teff and log(g) for each object. For all objects, we provide coordinates, proper motions, SDSS photometric magnitudes, and enough information to retrieve the spectrum/image from the SDSS public database. This catalog nearly doubles the known sample of spectroscopically-identified white dwarf stars. In the DR1 imaged area of the sky, we increase the known sample of white dwarf stars by a factor of 8.5. We also comment on several particularly interesting objects in this sample.Comment: To be published ApJ, 20May04. 52 pages, 13 figures, 12 tables. Full tables are available at the (now-corrected) SDSS DR1 Value-added catalog at http://www.sdss.org/dr1/products/value_added/index.htm