Mnogie stany ropne utrudniające rozpoznanie, wikłające przebieg i leczenie chłoniaka Hodgkina u 29-letniego mężczyzny — opis przypadku

Chłoniak Hodgkina (HL) jest chorobą nowotworową tkanki limfoidalnej. Cechuje się występowaniem monoklonalnych komórek Reed–Sternberga oraz komórek Hodgkina, które powodują masywny odczyn prawidłowych limfocytów w węzłach chłonnych. Rokowanie u chorych na HL zależy od stopnia zaawansowania choroby. Metodą referencyjną w leczeniu pierwszej linii jest chemioterapia według schematu ABVD zawierającą adriamycynę, bleomycnę winblastynę i dekarbazynę. W pracy przedstawiono opis przypadku chorego na chłoniaka Hodgkina z współistniejącym zakażeniem gronkowcem złocistym. W trakcie leczenia obserwowano krwiopochodne zapalenie stawu biodrowego ze wstrząsem septycznym. Powikłanie leczono operacyjne poprzez usunięcie torebki stawowej, głowy i szyjki kości udowej prawej. Po okresie rekonwalescencji kontynuowano zaplanowane leczenie systemowe uzyskując całkowitą remisję

Pazopanib in clear cell sarcoma therapy

Clear cell sarcoma (CCS) is a rare soft-tissue sarcoma and is characterized by a translocation t(12;22) (q13;q12). Because of some similarities to maligned melanoma it is called melanoma of soft parts. CCS has characteristic clinical features. It is commonly reported in young adults as slowly growing tumor followed by aggressive course. Its features are: regional lymph node spread and tendency for local recurrence and a propensity for pulmonary metastasis. Metastatic CCS is a very aggressive disease with pure prognosis. Conventional chemotherapy has little role to play in the management of CCS. The article presents the case of a patient with metastatic CCS with massive lung dissemination, metastatic in liver, left adrenal, pelvis and superficial soft tissue. In patient pazopanib therapy resulted in nine-month control of the disease

The role of histopathological examination, therapeutic difficulties and thromboembolism treatment during palliative chemotherapy in patient with antithrombin deficiency, colon cancer and endometrial cancer

Palliative chemotherapy in patients with thrombophilia is a challenge for clinical oncologists. On one hand the optimal treatment should be very safe for patient, on the other hand – as effective as possible. That therapy is also connected with proper thromboprophylaxis. The incidence of multiple cancers is a serious problem of modern oncology. In patients whose medical history includes two or more cancers, it is essential to obtain histopathological diagnosis before the administration of treatment of disseminated disease. It allows to avoid improper therapy which is often toxic. The article presents the case of a patient with antithrombin deficiency and two cancers in medical history: colon cancer and endometrial cancer. The treatment of the patient because of the metastatic cancer was started after the histopathological diagnosis. In metastatic lymph node the endometrial cancer was recognized. The carboplatin and paclitaxel were used in the therapy. The treatment was conducted in four course chemotherapy. It revealed considerable polyneuropathy and hematologic toxicity limiting from further therapy. Treatment allowed to obtain biochemical response, decrease of metastases and the condition of a patient improved. During the systemic therapy thromboprophylaxis with acenocumarol was used. The incidence of venous thromboembolism or bleeding complications were not noticed

Comprehensive Geriatric Assessment (CGA) in qualification for palliative chemotherapy

More than a half of new cancer cases affects elderly people. The number of patients in that group is constantly raising. Geriatric patients with cancer are very ununiform group with their biological age, comorbidities and conditions. The risk of the treatment’s toxicity in that group is increased due to loss of organ reserves. Based not only on metrical age or performance status but using precise assessment aids with choosing proper treatment this lowers the complication rate. Comprehensive Geriatric Assessment (CGA) is a multidimensional tool that helps assess elderly patients including daily living, physical status, cognitive functions, depression, nutrition and comorbidities. The following describes utility of CGA in 77-year-old male with colon cancer being qualified for palliative chemotherap