An introspective analysis of the etiological relationships of psychopathy in serial killers and successful business men

Ted Bundy. Jeffrey Dahmer. Charles Manson. Decades following their acts of violence, their names continue to incite fear as well as perplexity into the motivations that brought about their heinous crimes. As individuals possessing psychopathic personalities, they used their charm and quick wit to both manipulate and gain the trust of their victims. While their names do not elicit the same emotional response as Bundy or Manson, Bernie Madoff and Steve Jobs may also express the symptomology characteristic of psychopathy. But rather than committing violent crimes, they channeled their talents to the advancement of their careers and toward financial gain. However, some developmental factors must have influenced the manner in which they chose to use their personality traits for their own gain. The key to these differences may involve the etiology at the foundation of their psychopathy and the ways in which their childhood experiences shaped their adult personalities

Exome Sequence Analysis of 14 Families With High Myopia

PURPOSE: To identify causal gene mutations in 14 families with autosomal dominant (AD) high myopia using exome sequencing. METHODS: Select individuals from 14 large Caucasian families with high myopia were exome sequenced. Gene variants were filtered to identify potential pathogenic changes. Sanger sequencing was used to confirm variants in original DNA, and to test for disease cosegregation in additional family members. Candidate genes and chromosomal loci previously associated with myopic refractive error and its endophenotypes were comprehensively screened. RESULTS: In 14 high myopia families, we identified 73 rare and 31 novel gene variants as candidates for pathogenicity. In seven of these families, two of the novel and eight of the rare variants were within known myopia loci. A total of 104 heterozygous nonsynonymous rare variants in 104 genes were identified in 10 out of 14 probands. Each variant cosegregated with affection status. No rare variants were identified in genes known to cause myopia or in genes closest to published genome-wide association study association signals for refractive error or its endophenotypes. CONCLUSIONS: Whole exome sequencing was performed to determine gene variants implicated in the pathogenesis of AD high myopia. This study provides new genes for consideration in the pathogenesis of high myopia, and may aid in the development of genetic profiling of those at greatest risk for attendant ocular morbidities of this disorder