59 research outputs found
Disorder-induced critical behavior in driven diffusive systems
Using dynamic renormalization group we study the transport in driven
diffusive systems in the presence of quenched random drift velocity with
long-range correlations along the transport direction. In dimensions
we find fixed points representing novel universality classes of
disorder-dominated self-organized criticality, and a continuous phase
transition at a critical variance of disorder. Numerical values of the scaling
exponents characterizing the distributions of relaxation clusters are in good
agreement with the exponents measured in natural river networks
Viral Capsid Is a Pathogen-Associated Molecular Pattern in Adenovirus Keratitis
Human adenovirus (HAdV) infection of the human eye, in particular serotypes 8, 19 and 37, induces the formation of corneal subepithelial leukocytic infiltrates. Using a unique mouse model of adenovirus keratitis, we studied the role of various virus-associated molecular patterns in subsequent innate immune responses of resident corneal cells to HAdV-37 infection. We found that neither viral DNA, viral gene expression, or viral replication was necessary for the development of keratitis. In contrast, empty viral capsid induced keratitis and a chemokine profile similar to intact virus. Transfected viral DNA did not induce leukocyte infiltration despite CCL2 expression similar to levels in virus infected corneas. Mice without toll-like receptor 9 (Tlr9) signaling developed clinical keratitis upon HAdV-37 infection similar to wild type mice, although the absolute numbers of activated monocytes in the cornea were less in Tlr9−/− mice. Virus induced leukocytic infiltrates and chemokine expression in mouse cornea could be blocked by treatment with a peptide containing arginine glycine aspartic acid (RGD). These results demonstrate that adenovirus infection of the cornea induces chemokine expression and subsequent infiltration by leukocytes principally through RGD contact between viral capsid and the host cell, possibly through direct interaction between the viral capsid penton base and host cell integrins
Different treatment strategies versus a common standard arm (CSA) in patients with newly diagnosed AML over the age of 60 years: a randomized German inter-group study
Topographisch-Statistisch-Geographisches Wörterbuch der sämmtlichen preußischen Staaten oder Beschreibung aller Provinzen, Kreise, Distrikte, Städte, Aemter, Flecken, Dörfer, Vorwerke, Flüsse, Seen, Berge, [et]c. [et]c. in den preußischen Staaten
[Leopold Krug]Autopsie nach Ex. der UB Greifswald u. der ULB Sachsen-Anhalt (Halle)Vorlageform der Veröffentlichungsangabe: Halle, bei Karl August Kümme
Paadern - Ramutten
Vorlageform des Erscheinungsvermerks: Halle, bei Karl August Kümmel, 1800
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