Peer Response Groups in the ESOL Classroom : A Study

This qualitative study is introduced through a discussion of peer response groups and the researcher\u27s interest in them. The guiding question of whether peer response groups are as useful for teaching writing ESOL classrooms as in first language classrooms is stated along with supplementary research questions. These are fol lowed by a review of relevant theories and summaries of peer response group hi story, social and cultural factors, and research done on peer response groups in first and additional language classrooms

Oh! look at that baby, who can she be? [first line of chorus]

Performers: Baby Dorothy JohnsonPiano and Voice (with lyrics

Targeting tumor-associated macrophages as a novel strategy against breast cancer

Tumor-associated macrophages (TAMs) are associated with tumor progression and metastasis. Here, we demonstrate for the first time that legumain, a member of the asparaginyl endopeptidase family functioning as a stress protein, overexpressed by TAMs, provides an ideal target molecule. In fact, a legumain-based DNA vaccine served as a tool to prove this point, as it induced a robust CD8(+) T cell response against TAMs, which dramatically reduced their density in tumor tissues and resulted in a marked decrease in proangiogenic factors released by TAMs such as TGF-β, TNF-α, MMP-9, and VEGF. This, in turn, led to a suppression of both tumor angiogenesis and tumor growth and metastasis. Importantly, the success of this strategy was demonstrated in murine models of metastatic breast, colon, and non–small cell lung cancers, where 75% of vaccinated mice survived lethal tumor cell challenges and 62% were completely free of metastases. In conclusion, decreasing the number of TAMs in the tumor stroma effectively altered the tumor microenvironment involved in tumor angiogenesis and progression to markedly suppress tumor growth and metastasis. Gaining better insights into the mechanisms required for an effective intervention in tumor growth and metastasis may ultimately lead to new therapeutic targets and better anticancer strategies