Hepatic Protoporphyria in Weanling Pigs

Hepato-cutaneous porphyria can be induced in weanling pigs. The collidine derivative, DDC, produces protoporphyria in these animals, associated with photosensitivity. This porphyria is characterized by accumulation of protoporphyrin in the bile and liver. Fecal protoporphyrin excretion is markedly increased. The levels of protoprophyrin in the bile and liver are dependent on the dosage level of DDC. Erythrocyte protoporphyrin levels are not elevated. Protoporphyrin in the plasma and skin of animals on the maximal DDC dose was demonstrated. There was no significant elevation of urinary porphyrins in the experimental pigs