Evaluation of the prevalence of silicone oil droplets in the vitreous in patients treated with multiple intravitreal drug injections

Background. At present, intraocular drops of silicone oil, which is a lubricant for disposable syringes used for intravitreal injections, are being actively studied. Among the undesirable effects of their presence are patient’s complaints of visual discomfort associated with floating opacities, as well as a potential connection with episodes of intraocular inflammation and increased intraocular pressure.The aim: to assess the prevalence of silicone oil droplets in the vitreous in patients treated with multiple intravitreal injections.Materials and methods. A single-center retrospective cohort study was carried out. Inclusion criterion: treatment with multiple (at least 5) intravitreal injections of drug solutions performed according to registered indications. The study group consisted of 86 eyes of 85 patients (56 women, 29 men; age – from 36 to 89 y.o., average – 71.7 y.o.), who received an average of 13.2 injections of solutions of various drugs.Results. Drops of silicone oil were detected by biomicroscopy in 57 eyes (66.28 %) and by ultrasonography in 76 (88.37 %). The coincidence of the results of applying the methods was recorded in 73.26 % of observations. Seven (8.1 %) patients had characteristic complaints. Four patients (4.7  %) had a history of aseptic vitreitis. The  hypothesis was  confirmed that the possibility of silicone oil droplets getting into the vitreous increases with the number of intravitreal injections. A similar relationship was established in relation to the possibility of the appearance of characteristic complaints in patients due to the presence of drops and episodes of aseptic vitreitis.Conclusion. The release of drops of silicone oil from syringes during intravitreal injections is an urgent problem that requires further study. In the Russian Federation, the situation is aggravated by the lack of prefilled syringes with drugs approved for administration into the eye cavity, as well as the lack of syringe models designed for use in ophthalmology

Method of statistical data processing: the influence of pharmacological drugs on white rats locomotor activity

The method of statistical processing of the experimental data on the effect of pharmaceuticals on the motor activity of white rats is given. The technique is applicable to small (up to 10) of paired samples. The ways of data verification for compliance with the normal distribution law are discussed. If we have a matching then t-test of Student is used. In case of discrepancy with normal distribution nonparametric tests must be applied.Приведена методика статистической обработки экспериментальных данных по изучению влияния фармакологических препаратов на двигательную активность белых крыс. Методика применима для малых (до 10) парных выборок. Обсуждаются способы проверки данных на соответствие нормальному закону распределения. При наличии соответствия использован t-критерий Стьюдента. В случае несоответствия нормальному закону применяются непараметрические критерии

Features of expression and amplification of the TOR2A gene in breast carcinoma cells.

The study is retrospective. Considered 104 cases of breast cancer. In each case, thelevelofexpressionandamplificationofTop2a was calculated. The normal expression level of Top2a was in 11.5% ofcasesofbreastcancerandischaracteristiconlyofthenormalstatusofthe Top2a gene. In all cases of breast cancer with amplification of the Top2a gene, we received overexpression of the Top2a enzyme. When comparing the expression level of Top2a in breast cancer subtypes, a significant difference was only found between the HR + / Her2- and HR- / Her2 + subtypes (p = 0.039). In determining the nature of the dependence of Top2a amplification with Top2a expression, we found that the synthesis of Top2a protein depends on the number of copies of the Top2a gene on the chromosome.В статье рассмотрено ретроспективное исследование 104 случаев РМЖ. В каждом случае рассчитывали уровень экспрессии и амплификации Тор2а. Нормальный уровень экспрессии Тор2а был в 11,5% случаев РМЖ и характерен только нормальному статусу гена Тор2а. Во всех случаях РМЖ с амплификацией гена Тор2а мы получили гиперэкспрессию фермента Тор2а. При сравнении уровня экспрессии Тор2а в подтипах РМЖ получили достоверное различие только между подтипами HR+/Her2- и HR-/ Her2+ (p=0,039). При определении характера зависимости амплификации Top2a с экспрессией Тор2а мы установили, что синтез белка Тор2а зависит от количества копий гена Top2a на хромосоме

Analysis of choroidal thickness in patients receiving anti-VEGF therapy for myopic chorioidal neovascularization (preliminary report)

The purpose of the study is the determination and analysis of indicators of choroidal thickness (CT) in the macula in patients with myopic choroidal neovascularization (mCNV) who received anti-VEGF therapy.Цель исследования — определение и анализ показателей толщины хориоидеи (ТХ) в макулярной области у пациентов с миопической хориоидальной неоваскуляризацией (мХНВ), получавших антиангиогенную терапию

Medium-term and long-term results of anti-VEGF therapy for myopic choroidal neovascularisation (preliminary report)

The article considers the results of a retrospective analysis of the treatment of myopic choroidal neovascularisation (mCNV) in 45 patients (49 eyes). The high efficacy of anti-VEGF therapy of mCNV with ranibizumab and aflibercept was demonstrated, which manifested itself in a statistically significant increase in the best corrected visual acuity and a decrease in the central retinal thickness during treatment, with the results being preserved in terms from 12 (n = 49) to 60 (n = 21) and more (n = 16) monthsВ статье рассмотрены результаты ретроспективного анализа лечения миопической хориоидальной неоваскуляризации (мХНВ) 45 пациентов (49 глаз). Продемонстрирована высокая эффективность антиангиогенной терапии мХНВ препаратами ранибизумаб и афлиберцепт, выразившаяся в статистически значимом повышении максимальной корригированной остроты зрения вдаль и снижении толщины сетчатки в центральной зоне на фоне лечения с сохранением результатов в сроки от 12 (n = 49) до 60 (n = 21) и более (n = 16) месяцев

Why are patients with macular diseases receiving anti-VEGF therapy lost to follow -up

The article provides an analysis of the results of a phone survey 214 patients who stopped anti-VEGF therapy of macular diseases in real clinical practice from 2011 to 2019. The following categories of respondents were identified: complete cessation of treatment - 120 (56.1%) patients, change of clinic - 20 (9.3%), death - 23 (10.7%), status not established - 51 (23.8%). The most frequent reasons for stopping treatment were dissatisfaction with its results (59 cases; 49.2%), financial burden (49; 40.8%) and general comorbidities (24; 20.0%).В статье приводится анализ результатов телефонного опроса 214 пациентов, прекративших антиангиогенную терапию заболеваний макулы в условиях реальной клинической практики за период с 2011 по 2019 год. Выявлены следующие категории респондентов, прекративших лечение: полное прекращение терапии - 120 (56,1%), смена клиники - 20 (9,3%), смерть - 23 (10,7%). Не удалось установить статус 51 (23,8%) человека. Наиболее частыми причинами прекращения лечения (n=120) стали неудовлетворенность его результатами (59 случаев; 49,2%), финансовое бремя (49; 40,8%) и общие сопутствующие заболевания (24; 20,0%

Assessment of the state of bone mineral density in postmenopausal women with chronic periodontitis

The aim of the study - to determine the state of bone mineral density in women with osteoporosis and chronic generalized periodontitis of moderate severity.Цель исследования - определить состояние минеральной плотности кости у женщин с остеопорозом и хроническим генерализованным пародонтитом средней степени тяжест