Using the lost letter technique to measure real-life behavioral effects of alcohol use

Introduction and aims: People’s behaviors after alcohol use are more extreme and alcohol has a narrowing effect on a person’s cognitive capacity. We tested this effect, making use of the Lost-Letter Technique (LLT), in which the return rate of “lost letters” by public mail is used to measure altruistic behavior. We hypothesized that return rates would be lower when people are under the influence of alcohol, and that an anti-alcohol prime in the address would even further decrease return rates. Design and methods: 768 letters were dropped, half of those at times when some degree of intoxication was likely versus when sober passers-by were common. Three different addressees were used to convey an anti-alcohol cue, a charitable cue, and a neutral cue. Results: The average response rate was 33.1%, and was significantly lower during late bar hours than during lunch hours (20.3% versus 45.8%). Also, when envelopes were found by people who were more likely to have consumed alcohol, anti-alcohol cues gained significantly lower response rates (12.7% versus 23.1%). Discussion and conclusions: This study confirms that alcohol use causes less altruistic behavior and different responses to alcohol-related cues, suggesting that LLT is a promising method to study people’s behavior. Future research could also focus on other substances, (mood-)states, and technology as a means of data collection

The role of acquaintanceship in the perception of child behaviour problems

The role of acquaintanceship with the child on reports of child behaviour by different informants was examined within the framework of a general theory of personality judgment. Mothers of referred children and group-care workers rated videotaped behaviour samples of a well known and an unknown child in the clinic. Independent observers also rated the videotapes. In line with the acquaintanceship hypothesis, mothers were found to perceive more behaviour problems than independent observers when rating well known children but not unknown children. Contrary to the acquaintanceship hypothesis, however, the group-care workers in our study reported more behaviour problems than the other informants regardless of their acquaintance with the children. The clinical and methodological implications of these findings are discussed

Prediction of response to biological treatment with monoclonal antibodies in severe asthma

In recent years, major developments have occurred in severe asthma management. Different asthma phenotypes and subgroups have been identified and new treatment options have become available. A total of five monoclonal antibodies are currently approved in severe asthma treatment: omalizumab, mepolizumab, reslizumab, benralizumab and dupilumab. These drugs have been shown to reduce exacerbations and to have an oral corticosteroid-sparing effect in many severe asthma patients. However, biological treatment is not successful in all patients and should be discontinued in non-responsive patients. Treating the right patient with the right biologic, and therefore biologic response prediction, has become a major point of interest in severe asthma management. A variety of response outcomes is utilized in the different clinical trials, as well as a huge range of potential predicting factors. Also, regarding the timing of the response evaluation, there are considerable differences between studies. This review summarizes the results from studies on predicting responses and responders to biological treatment in severe asthma, taking into account clinical, functional and inflammatory parameters assessed prior to the start of treatment as well as following a few months of therapy. In addition, future perspectives are discussed, highlighting the need for more research to improve patient identification and treatment responses in the field of biological treatment in severe asthma

Methane dissociation on Pt(111): Searching for a specific reaction parameter density functional

Theoretical Chemistr

Forces on a boiling bubble in a developing boundary layer, in microgravity with g-jitter and in terrestrial conditions

Terrestrial and microgravity flow boiling experiments were carried out with the same test rig, comprising a locally heated artificial cavity in the center of a channel near the frontal edge of an intrusive glass bubble generator. Bubble shapes were in microgravity generally not far from those of truncated spheres,which permitted the computation of inertial lift and drag from potential flow theory for truncated spheres approximating the actual shape. For these bubbles, inertial lift is counteracted by drag and both forces are of the same order of magnitude as g-jitter. A generalization of the Laplace equation is found which applies to a deforming bubble attached to a plane wall and yields the pressure difference between the hydrostatic pressures in the bubble and at the wall, p. A fully independent way to determine the overpressure p is given by a second Euler-Lagrange equation. Relative differences have been found to be about 5% for both terrestrial and microgravity bubbles. A way is found to determine the sum of the two counteracting major force contributions on a bubble in the direction normal to the wall from a single directly measurable quantity. Good agreement with expectation values for terrestrial bubbles was obtained with the difference in radii of curvature averaged over the liquid-vapor interface, (1/R2 − 1/R1), multiplied with the surface tension coefficient, σ. The new analysis methods of force components presented also permit the accounting for a surface tension gradient along the liquid-vapor interface. No such gradients were found for the present measurements

Atomic diffraction from nanostructured optical potentials

We develop a versatile theoretical approach to the study of cold-atom diffractive scattering from light-field gratings by combining calculations of the optical near-field, generated by evanescent waves close to the surface of periodic nanostructured arrays, together with advanced atom wavepacket propagation on this optical potential.Comment: 8 figures, 10 pages, submitted to Phys. Rev.

Application of van der Waals functionals to the calculation of dissociative adsorption of N 2

Theoretical Chemistr

Life satisfaction amongst police officers working in the area of child abuse investigation

Child abuse investigation is an area of work reported to be associated with high levels of work stress. This potentially places professionals at risk of psychological harm and may lead to lower life satisfaction than in the general population. The current study examined this issue within a large sample of Australian police officers. Specifically, 214 officers working in the area of child abuse investigation responded to a single global measure of life satisfaction (LS) known to be highly related to other measures of subjective wellbeing as well as clinical depression. The results revealed that, irrespective of the officers&rsquo; gender or degree of exposure to child abuse cases, the mean score from LS score was within the expected adult normative range. Further, the overall incidence of low LS in this sample (1.9 per cent) was not significantly different from the general population (4.3 per cent). The implications of these findings for police organisations are discussed.<br /

The use of a direct bronchial challenge test in primary care to diagnose asthma

Many asthmatics in primary care have mild symptoms and lack airflow obstruction. If variable expiratory airflow limitation cannot be determined by spirometry or peak expiratory flow, despite a history of respiratory symptoms, a positive bronchial challenge test (BCT) can confirm the diagnosis of asthma. However, BCT is traditionally performed in secondary care. In this observational real-life study, we retrospectively analyze 5-year data of a primary care diagnostic center carrying out BCT by histamine provocation. In total, 998 primary care patients aged ≥16 years underwent BCT, without any adverse events reported. To explore diagnostic accuracy, we examine 584 patients with a high pretest probability of asthma. Fifty-seven percent of these patients have a positive BCT result and can be accurately diagnosed with asthma. Our real-life data show BCT is safe and feasible in a suitably equipped primary care diagnostic center. Furthermore, it could potentially reduce diagnostic referrals to secondary care

N 2

Theoretical Chemistr