457 research outputs found
Mast cell tumours and other skin neoplasia in Danish dogs - data from the Danish Veterinary Cancer Registry
<p>Abstract</p> <p>Background</p> <p>The Danish Veterinary Cancer Registry (DVCR) was established in May 2005 to gather information about neoplasms in the Danish dog and cat populations. Practitioners from more than 60 clinics throughout Denmark have submitted data on these species. The objectives of the current study were, with a special focus on mast cell tumours (MCT) to investigate the occurrence, gender distribution, biological behaviour, locations, types, the diagnostic method used and treatment of skin neoplasms in dogs based on information reported to the DVCR.</p> <p>Methods</p> <p>From May 15<sup>th </sup>2005 through February 29<sup>th </sup>2008, reports on a total of 1,768 canine cases of neoplasia in the skin, subcutis or adnexa were submitted.) Of these, 765 cases (43%) were confirmed by cytology or histopathology.</p> <p>Results</p> <p>The majority of dogs had a benign neoplasm (66%) while 21% were cases of malignant neoplasia. The most commonly encountered malignant neoplasms were MCT and soft tissue sarcomas and for benign neoplasms, lipomas and histiocytomas were the most common. The location of the neoplasms were primarily in the cutis, subcutis or in the perianal region. The occurrence, gender distribution, biological behaviour and location of canine skin neoplasias in Denmark were similar to earlier reports, although some national variations occurred. A correlation between grade of MCT and the proportion of cases treated surgically was observed.</p> <p>Conclusions</p> <p>Population based cancer registries like the DVCR are of importance in the collection of non-selected primary information about occurrence and distribution of neoplasms. The DVCR provides detailed information on cases of skin neoplasms in dogs and may serve as a platform for the study of sub-sets of neoplastic diseases (e.g. MCT) or subgroups of the canine population (e.g. a specific breed).</p
Oral malignant melanomas and other head and neck neoplasms in Danish dogs - data from the Danish Veterinary Cancer Registry
<p>Abstract</p> <p>Background</p> <p>Head and neck cancers (HNC) are relatively common and often very serious diseases in both dogs and humans. Neoplasms originating in the head and neck region are a heterogeneous group. HNC often has an unfavourable prognosis and the proximity of the tissue structures renders extirpation of tumours with sufficient margins almost incompatible with preservation of functionality. In humans oral malignant melanoma (OMM) is extremely rare, but represents a particular challenge since it is highly aggressive as is the canine counterpart, which thus may be of interest as a spontaneous animal model.</p> <p>Methods</p> <p>Canine cases entered in the Danish Veterinary Cancer Registry (DVCR) from May 15th 2005 through February 29th 2008 were included in this study. Fisher's exact test was used to compare proportions of HNC in dogs and humans as well as proportions of surgically treated cases of OMM and squamous cell carcinomas (SCC). Also the proportions of benign and malignant neoplasms of different locations in dogs were compared using Fisher's exact test.</p> <p>Results</p> <p>A total of 1768 cases of neoplasias (679 malignant, 826 benign, 263 unknown) were submitted. Of all neoplasias HNC accounted for 7.2% (n = 128). Of these, 64 (50%) were malignant and 44 (34%) benign. The most common types of malignant neoplasia were SCC (18; 28% of malignant), OMM (13; 20% of malignant), soft tissue sarcoma (11; 17% of malignant) and adenocarcinoma (5; 11% of malignant). The most common types of benign neoplasms were adenoma (7; 16% of benign), polyps (6; 14% of benign) and fibroma (5; 11% of benign).</p> <p>Conclusions</p> <p>In the current study, the proportion of neoplasia in the head and neck region in dogs in Denmark was similar to other canine studies and significantly more common than in humans with a large proportion of malignancies. Spontaneous HNC in dogs thus, may serve as a model for HNC in humans.</p> <p>Canine OMM is a spontaneous cancer in an outbred, immune-competent large mammal population and could be a clinical model for OMM in humans.</p
Bias and temperature dependence of the 0.7 conductance anomaly in Quantum Point Contacts
The 0.7 (2e^2/h) conductance anomaly is studied in strongly confined, etched
GaAs/GaAlAs quantum point contacts, by measuring the differential conductance
as a function of source-drain and gate bias as well as a function of
temperature. We investigate in detail how, for a given gate voltage, the
differential conductance depends on the finite bias voltage and find a
so-called self-gating effect, which we correct for. The 0.7 anomaly at zero
bias is found to evolve smoothly into a conductance plateau at 0.85 (2e^2/h) at
finite bias. Varying the gate voltage the transition between the 1.0 and the
0.85 (2e^2/h) plateaus occurs for definite bias voltages, which defines a gate
voltage dependent energy difference . This energy difference is
compared with the activation temperature T_a extracted from the experimentally
observed activated behavior of the 0.7 anomaly at low bias. We find \Delta =
k_B T_a which lends support to the idea that the conductance anomaly is due to
transmission through two conduction channels, of which the one with its subband
edge \Delta below the chemical potential becomes thermally depopulated as the
temperature is increased.Comment: 9 pages (RevTex) with 9 figures (some in low resolution
Tourniquets do not increase the total blood loss or re-amputation risk in transtibial amputations
AIM: To investigate the total blood loss (TBL) and the safety with respect to the re-amputation rate after transtibial amputation (TTA) conducted with and without a tourniquet. METHODS: The study was a single-centre retrospective cohort study of patients with a primary TTA admitted between January 2013 and April 2015. All patients with a primary TTA were assessed for inclusion if the amputation was performed because of arteriosclerosis or diabetic complications. All patients underwent a standardized TTA procedure that was performed approximately 10 cm below the knee joint and performed with sagittal flaps. The pneumatic tourniquet, when used, was inflated around the femur to a pressure of 100 mmHg above the systolic blood pressure. The number of blood transfusions within the first four postoperative days was recorded. The intraoperative blood loss (OBL), which is defined as the volume of blood lost during surgery, was determined from the suction volume and by the weight difference of the surgical dressings. The trigger for a blood transfusion was set at a decrease in the Hgb level < 9.67 g/dL (6 mmol/L). Transfusions were performed with pooled red blood cells containing 245 mL per portion, which equals 55 g/L of haemoglobin. The TBL during the first four postoperative days was calculated based on the haemoglobin level and the estimated blood volume. The re-amputation rate was evaluated within 30 d. RESULTS: Seventy-four out of 86 consecutive patients who underwent TTA within the two-year study period were included in the analysis. Of these, 38 were operated on using a tourniquet and 36 were operated on without using a tourniquet. There were no significant preoperative differences between the groups. The patients in both groups had a postoperative decrease in their Hgb level compared with preoperative baseline values. The patients operated on using a tourniquet received approximately three millilitres less blood transfusion per kilogram body weight compared with patients operated on without a tourniquet. The duration of surgery was shorter and the OBL was less for the tourniquet group than the non-tourniquet group, whereas no significant difference was observed for the TBL. The TBL median was 859 mL (IQR: 383-1315) in the non-tourniquet group vs 737 mL (IQR: 331-1218) in the tourniquet group (P = 0.754). Within the 30-d follow-up period, 9 patients in the tourniquet group and 11 in the non-tourniquet group underwent a re-amputation at the trans-femoral level. The use of a tourniquet showed no statistically significant association with the 30-d re-amputation at the femur level in the multiple logistic regression model (P = 0.78). The only variable with a significant association with re-amputation was age (OR = 1.07; P = 0.02). CONCLUSION: The results indicate that tourniquets do not cause severe vascular damage with an increased postoperative bleeding or failure rate as the result
Total Blood Loss After Transfemoral Amputations Is Twice the Intraoperative Loss:An Observational Cohort Study of 81 Nontraumatic Amputations
Many-body spin related phenomena in ultra-low-disorder quantum wires
Zero length quantum wires (or point contacts) exhibit unexplained conductance
structure close to 0.7 X 2e^2/h in the absence of an applied magnetic field. We
have studied the density- and temperature-dependent conductance of
ultra-low-disorder GaAs/AlGaAs quantum wires with nominal lengths l=0 and 2 mu
m, fabricated from structures free of the disorder associated with modulation
doping. In a direct comparison we observe structure near 0.7 X 2e^2/h for l=0
whereas the l=2 mu m wires show structure evolving with increasing electron
density to 0.5 X 2e^2/h in zero magnetic field, the value expected for an ideal
spin-split sub-band. Our results suggest the dominant mechanism through which
electrons interact can be strongly affected by the length of the 1D region.Comment: 5 Pages, 4 figure
Spin-dependent thermoelectric transport coefficients in near-perfect quantum wires
Thermoelectric transport coefficients are determined for semiconductor
quantum wires with weak thickness fluctuations. Such systems exhibit anomalies
in conductance near 1/4 and 3/4 of 2e^2/h on the rising edge to the first
conductance plateau, explained by singlet and triplet resonances of conducting
electrons with a single weakly bound electron in the wire [T. Rejec, A. Ramsak,
and J.H. Jefferson, Phys. Rev. B 62, 12985 (2000)]. We extend this work to
study the Seebeck thermopower coefficient and linear thermal conductance within
the framework of the Landauer-Buettiker formalism, which also exhibit anomalous
structures. These features are generic and robust, surviving to temperatures of
a few degrees. It is shown quantitatively how at elevated temperatures thermal
conductance progressively deviates from the Wiedemann-Franz law.Comment: To appear in Phys. Rev. B 2002; 3 figure
Restricted and unrestricted Hartree-Fock calculations of conductance for a quantum point contact
Very short quantum wires (quantum contacts) exhibit a conductance structure
at a value of conductance close to . It is believed that the
structure arises due to the electron-electron interaction, and it is also
related to electron spin. However details of the mechanism of the structure are
not quite clear. Previously we approached the problem within the restricted
Hartree-Fock approximation. This calculation demonstrated a structure similar
to that observed experimentally. In the present work we perform restricted and
unrestricted Hartree-Fock calculations to analyze the validity of the
approximations. We also consider dependence of the effect on the electron
density in leads. The unrestricted Hartree-Fock method allows us to analyze
trapping of the single electron within the contact. Such trapping would result
in the Kondo model for the ``0.7 structure''. The present calculation confirms
the spin-dependent bound state picture and does not confirm the Kondo model
scenario.Comment: 6 pages, 9 figure
Effect of the spin-orbit interaction on the band structure and conductance of quasi-one-dimensional systems
We discuss the effect of the spin-orbit interaction on the band structure,
wave functions and low temperature conductance of long quasi-one-dimensional
electron systems patterned in two-dimensional electron gases (2DEG). Our model
for these systems consists of a linear (Rashba) potential confinement in the
direction perpendicular to the 2DEG and a parabolic confinement transverse to
the 2DEG. We find that these two terms can significantly affect the band
structure introducing a wave vector dependence to subband energies, producing
additional subband minima and inducing anticrossings between subbands. We
discuss the origin of these effects in the symmetries of the subband wave
functions.Comment: 15 pages including 14 figures; RevTeX; to appear in Phys.Rev.B (15
Nov 1999
Extreme sensitivity of the spin-splitting and 0.7 anomaly to confining potential in one-dimensional nanoelectronic devices
Quantum point contacts (QPCs) have shown promise as nanoscale spin-selective
components for spintronic applications and are of fundamental interest in the
study of electron many-body effects such as the 0.7 x 2e^2/h anomaly. We report
on the dependence of the 1D Lande g-factor g* and 0.7 anomaly on electron
density and confinement in QPCs with two different top-gate architectures. We
obtain g* values up to 2.8 for the lowest 1D subband, significantly exceeding
previous in-plane g-factor values in AlGaAs/GaAs QPCs, and approaching that in
InGaAs/InP QPCs. We show that g* is highly sensitive to confinement potential,
particularly for the lowest 1D subband. This suggests careful management of the
QPC's confinement potential may enable the high g* desirable for spintronic
applications without resorting to narrow-gap materials such as InAs or InSb.
The 0.7 anomaly and zero-bias peak are also highly sensitive to confining
potential, explaining the conflicting density dependencies of the 0.7 anomaly
in the literature.Comment: 23 pages, 7 figure
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