12 research outputs found
Effect of antidepressant medication use during pregnancy on preterm birth: meta-analysis results.
(1)<p>Typically 1st trimester; some women continued during pregnancy, others discontinued.</p>(2)<p>Typically 3<sup>rd</sup> trimester.</p>(3)<p>Factors varied between studies, but typically included maternal age, smoking, alcohol use, parity, and history of prematurity or miscarriage.</p>(4)<p>Values of I<sup>2</sup> are percentages (% of variance explained). 95% uncertainty intervals are calculated as proposed by Higgins and Thompson <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0092778#pone.0092778-Higgins1" target="_blank">[89]</a>.</p
Study-specific and pooled odds ratio estimates for antidepressant medication during pregnancy and preterm birth.
<p>Studies that did not adjust for other risk factors.</p
Adjusted study-specific and pooled odds ratio estimates for antidepressant medication during pregnancy and preterm birth.
<p>Subset of studies that account for the underlying psychiatric illness.</p
Characteristics of 41 studies evaluating the association between antidepressant medication use during pregnancy and preterm birth.
<p>Abbreviations: Prosp = Prospective cohort; Retro = Retrospective cohort; depr = depression; AD = antidepressant; SRI = serotonin reuptake inhibitor; TCA = tricyclic antidepressant; NaSSA = Noradrenergic and specific serotonergic antidepressants; SNRI = Serotonin–norepinephrine reuptake inhibitors; NRI = noradrenaline reuptake inhibitors; T = trimester; exp = exposed; TIS = Teratogen Information Service.</p
Sensitivity analysis of residual confounding (Rule-out approach).
<p>Example for estimated OR = 1.61 (depression adjusted point estimate) and OR = 1.26 (lower 95% bound of depression adjusted estimate) for different levels of confounder prevalence (▪ P<sub>c</sub> = 0.05, OR = 1.61; •P<sub>c</sub> = 0.25, OR = 1.61; □ P<sub>c</sub> = 0.05, OR = 1.26; ○P<sub>c</sub> = 0.25, OR = 1.26). Each line splits the area into two. The upper right area represents all combinations of OR<sub>EC</sub> and RR<sub>CD</sub> that would create confounding by an unmeasured factor strong enough to move the point estimate of OR to the null (OR = 1) or beyond. The area to the lower left represents all parameter combinations that would not be able to move the estimated OR to the null.</p
Funnel plot with pseudo 95% confidence limits.
<p>Funnel plot with pseudo 95% confidence limits.</p
Overview of the linkage and cohort identification process; Medicaid Analytic eXtract, 2000–2007.
<p>Overview of the linkage and cohort identification process; Medicaid Analytic eXtract, 2000–2007.</p
Number of pregnancies contributed to the base cohort by state; Medicaid Analytic eXtract, 2000–2007.
<p>Number of pregnancies contributed to the base cohort by state; Medicaid Analytic eXtract, 2000–2007.</p
The number of deliveries before linkage and the percentage of deliveries that linked to an infant, and the number of child MSIS_ID and date of birth combinations before linkage and the percentage of combinations that linked to a delivery listed by inpatient and outpatient linkage and by state; Medicaid Analytic eXtract, 2000–2007.
<p>The number of deliveries before linkage and the percentage of deliveries that linked to an infant, and the number of child MSIS_ID and date of birth combinations before linkage and the percentage of combinations that linked to a delivery listed by inpatient and outpatient linkage and by state; Medicaid Analytic eXtract, 2000–2007.</p