100 research outputs found
PDB17 GLYCEMIC VARIABILITY AND COMPLICATIONS IN PATIENTS WITH DIABETES MELLITUS: EVIDENCE FROM A SYSTEMATIC REVIEW OF THE LITERATURE
Risk of cardiometabolic outcomes among women with a history of pelvic inflammatory disease:A retrospective matched cohort study from the UK
Clinically meaningful and lasting HbA1c improvement rarely occurs after 5 years of type 1 diabetes: an argument for early, targeted and aggressive intervention following diagnosis.
AIMS/HYPOTHESIS: Our objectives were to explore whether the phenomenon of HbA1c 'tracking' occurs in individuals with type 1 diabetes, how long after diagnosis does tracking take to stabilise, and whether there is an effect of sex and age at diagnosis on tracking. METHODS: A total of 4525 individuals diagnosed with type 1 diabetes between 1 January 1995 and 1 May 2015 were identified from The Health Improvement Network (THIN) database. Mixed models were applied to assess the variability of HbA1c levels over time with random effects on general practices (primary care units) and individuals within practices. RESULTS: 4525 individuals diagnosed with type 1 diabetes were identified in THIN over the study period. The greatest difference in mean HbA1c measurement (-7.0 [95% CI -8.0, -6.1] mmol/mol [0.6%]) was seen when comparing measurements made immediately after diagnosis (0-1 year since diagnosis) with those at 10 or more years (the reference category). The mean difference in HbA1c for the successive periods compared with 10 or more years after diagnosis declined and was no longer statistically significant after 5 years. In the stratified analysis using sex and age group there was considerable heterogeneity with adult onset type 1 diabetes appearing to track earlier and at a lower mean HbA1c. CONCLUSIONS/INTERPRETATION: In individuals with type 1 diabetes, glycaemic control measured by HbA1c settles onto a long-term 'track' and this occurs on average by 5 years following diagnosis. Age at diagnosis modifies both the rate at which individuals settle into their track and the absolute HbA1c tracking level for the next 10 years
Risk of cardiovascular outcomes among women with endometriosis in the United Kingdom:a retrospective matched cohort study
The association between menstrual cycle characteristics and cardiometabolic outcomes in later life:A retrospective matched cohort study of 704,743 women from the UK.
PDB76 TREATMENT SATISFACTION IS POSITIVELY ASSOCIATED WITH GLYCEMIC CONTROLAND NEGATIVELY ASSOCIATED WITH PATIENT REPORTED EXPERIENCE OF HYPOGLYCEMIC SYMPTOMS AMONG PATIENTS WITH TYPE-2 DIABETES MELLITUS (T2DM) ON ORAL ANTI-HYPERGLYCEMIC AGENTS (OHA) IN EUROPE
The association between the reproductive health of young women and cardiovascular disease in later life:An umbrella review
Thyroid replacement therapy, thyroid stimulating hormone levels and long-term health outcomes in patients with hypothyroidism:a longitudinal study
Safety and efficacy of tuberculosis vaccine candidates in low- and middle-income countries:a systematic review of randomised controlled clinical trials
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