Hemodynamic energy dissipation in the cardiovascular system: generalized theoretical analysis on disease states.

BACKGROUND: We present a fundamental theoretical framework for analysis of energy dissipation in any component of the circulatory system and formulate the full energy budget for both venous and arterial circulations. New indices allowing disease-specific subject-to-subject comparisons and disease-to-disease hemodynamic evaluation (quantifying the hemodynamic severity of one vascular disease type to the other) are presented based on this formalism. METHODS AND RESULTS: Dimensional analysis of energy dissipation rate with respect to the human circulation shows that the rate of energy dissipation is inversely proportional to the square of the patient body surface area and directly proportional to the cube of cardiac output. This result verified the established formulae for energy loss in aortic stenosis that was solely derived through empirical clinical experience. Three new indices are introduced to evaluate more complex disease states: (1) circulation energy dissipation index (CEDI), (2) aortic valve energy dissipation index (AV-EDI), and (3) total cavopulmonary connection energy dissipation index (TCPC-EDI). CEDI is based on the full energy budget of the circulation and is the proper measure of the work performed by the ventricle relative to the net energy spent in overcoming frictional forces. It is shown to be 4.01+/-0.16 for healthy individuals and above 7.0 for patients with severe aortic stenosis. Application of CEDI index on single-ventricle venous physiology reveals that the surgically created Fontan circulation, which is indeed palliative, progressively degrades in hemodynamic efficiency with growth (p CONCLUSIONS: Energy dissipation in the human circulation has been analyzed theoretically to derive the proper scaling (indexing) factor. CEDI, AV-EDI, and TCPC-EDI are proper measures of the dissipative characteristics of the circulatory system, aortic valve, and the Fontan connection, respectively.</p