1,006 research outputs found
The efficacy of halofantrine in the treatment of acute malaria in nonimmune travelers
A multicenter prospective trial was performed to investigate the efficacy and the tolerability of halofantrine in nonimmune patients with malaria imported from areas with drug-resistant falciparum parasites (mainly Africa). Forty-five of the 74 subjects were treated with a one-day regimen (3 x 500 mg) of halofantrine, and the other 29 received the same regimen with an additional treatment on day 7. In the second group, a 100% efficacy rate was demonstrated, but in the group receiving the one-day regimen, four recrudescences were observed in patients with falciparum malaria. Only five mild adverse reactions were seen, which disappeared spontaneously after the end of the treatment. We conclude that halofantrine is highly effective in curing malaria in nonimmune subjects. The treatment scheme for such persons should include an additional treatment on day 7 for nonimmune individuals. This drug was well tolerated in our patients, indicating that halofantrine will be useful in the treatment of multidrug-resistant malaria in nonimmune persons
Challenges for Developing Rechargeable Room-Temperature Sodium Oxygen Batteries
© 2018 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The development of high energy-density and low-cost energy storage devices requires new chemistry beyond the horizon of current state-of-the-art lithium-ion batteries. Recently, sodium/oxygen (Na/O2) batteries have attracted great attention as one possible battery type among the new generation of rechargeable batteries. They convince with superior energy density, a relatively simple cell reaction, and abundance of sodium. Research on Na/O2 batteries has progressed quickly in recent years. However, a fundamental understanding underpinning the complex chemical/electrochemical side reactions is still insufficient, and many challenges remain unsolved for real practical applications. Herein, recent achievements and remaining issues for the development of rechargeable Na/O2 batteries are summarized. The discussion focuses on cell reaction mechanisms as well as cathode materials, sodium anodes, and electrolytes as key components of this type of battery. Furthermore, perspectives for future research and technological advances of Na/O2 batteries are outlined
Metric Features of a Dipolar Model
The lattice spin model, with nearest neighbor ferromagnetic exchange and long
range dipolar interaction, is studied by the method of time series for
observables based on cluster configurations and associated partitions, such as
Shannon entropy, Hamming and Rohlin distances. Previous results based on the
two peaks shape of the specific heat, suggested the existence of two possible
transitions. By the analysis of the Shannon entropy we are able to prove that
the first one is a true phase transition corresponding to a particular melting
process of oriented domains, where colored noise is present almost
independently of true fractality. The second one is not a real transition and
it may be ascribed to a smooth balancing between two geometrical effects: a
progressive fragmentation of the big clusters (possibly creating fractals), and
the slow onset of a small clusters chaotic phase. Comparison with the nearest
neighbor Ising ferromagnetic system points out a substantial difference in the
cluster geometrical properties of the two models and in their critical
behavior.Comment: 20 pages, 15 figures, submitted to JPhys
Ensuring the Visibility and Accessibility of European Creative Content on the World Market:The Need for Copyright Data Improvement in the Light of New Technologies and the Opportunity Arising from Article 17 of the CDSM Directive
Non-Hermitian SUSY Hydrogen-like Hamiltonians with real spectra
It is shown that the radial part of the Hydrogen Hamiltonian factorizes as
the product of two not mutually adjoint first order differential operators plus
a complex constant epsilon. The 1-susy approach is used to construct
non-hermitian Hamiltonians with hydrogen spectra. Other non-hermitian
Hamiltonians are shown to admit an extra `complex energy' at epsilon. New
self-adjoint hydrogen-like Hamiltonians are also derived by using a 2-susy
transformation with complex conjugate pairs epsilon, (c.c) epsilon.Comment: LaTeX2e file, 13 pages, 6 EPS figures. New references added. The
present is a reorganized and simplified versio
Ensuring the Visibility and Accessibility of European Creative Content on the World Market:The Need for Copyright Data Improvement in the Light of New Technologies and the Opportunity Arising from Article 17 of the CDSM Directive
Ordering of dipolar Ising crystals
We study Ising systems of spins with dipolar interactions. We find a simple
approximate relation for the interaction energy between pairs of parallel
lattice columns of spins running along the Ising spin direction. This relation
provides insight into the relation between lattice geometry and the nature of
the ordered state. It can be used to calculate ground state energies. We have
also obtained ground state energies and ordering temperatures T_0 from Monte
Carlo simulations. Simple empirical relations, that give T_0 for simple and
body centered tetragonal lattices in terms of lattice parameters are also
established. Finally, the nature of the ordered state and T_0 are determined
for Fe_8 clusters, which crystallize on a triclinic lattice.Comment: 13 pages, 4 eps figures, to be published in PRB. For related work,
see http://pipe.unizar.es/~jf
Increasing Dominance - the Role of Advertising, Pricing and Product Design
Despite the empirical relevance of advertising strategies in concentrated markets, the economics literature is largely silent on the effect of persuasive advertising
strategies on pricing, market structure and increasing (or decreasing) dominance. In a simple model of persuasive advertising and pricing with differentiated goods,
we analyze the interdependencies between ex-ante asymmetries in consumer appeal, advertising and prices. Products with larger initial appeal to consumers will
be advertised more heavily but priced at a higher level - that is, advertising and price discounts are strategic substitutes for products with asymmetric initial appeal.
We find that the escalating effect of advertising dominates the moderating effect of pricing so that post-competition market shares are more asymmetric than pre-competition differences in consumer appeal. We further find that collusive advertising (but competitive pricing) generates the same market outcomes, and that network effects lead to even more extreme market outcomes, both directly and via
the effect on advertising
Copyright Contracts and Earnings of Visual Creators: A Survey of 5,800 British Designers, Fine Artists, Illustrators and Photographers
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