Non-spherical collapse of an air bubble subjected to a lithotripter pulse

In order to better understand the contribution of bubble collapse to stone comminution in shockwave lithotripsy, the shockinduced and Rayleigh collapse of a spherical air bubble is investigated using numerical simulations, and the free-field collapse of a cavitation bubble is studied experimentally. In shock-induced collapse near a wall, it is found that the presence of the bubble greatly amplifies the pressure recorded at the stone surface; the functional dependence of the wall pressure on the initial standoff distance and the amplitude are presented. In Rayleigh collapse near a solid surface, the proximity of the wall retards the flow and leads to a more prominent jet. Experiments show that re-entrant jets form in the collapse of cavitation bubbles excited by lithotripter shockwaves in a fashion comparable to previous studies of collapse near a solid surface

Annual acknowledgement of manuscript reviewers

The editors of Journal of the International Society of Sports Nutrition would like to thank all our reviewers who have contributed to the journal in Volume 10 (2013). The tireless work that all of you have given to us to enhance our journal is highly appreciated. We can’t thank you enough

Investigation of the Energy Shielding of Kidney Stones by Cavitation Bubble Clouds during Burst Wave Lithotripsy

We conduct experiments and numerical simulations of the dynamics of bubble clouds nucleated on the surface of an epoxy cylindrical stone model during burst wave lithotripsy (BWL). In the experiment, the bubble clouds are visualized and bubble-scattered acoustics are measured. In the numerical simulation, we combine methods for modeling compressible multicomponent flows to capture complex interactions among cavitation bubbles, the stone, and the burst wave. Quantitative agreement is confirmed between results of the experiment and the simulation. We observe and quantify a significant shielding of incident wave energy by the bubble clouds. The magnitude of shielding reaches up to 80% of the total acoustic energy of the incoming burst wave, suggesting a potential loss of efficacy of stone comminution. We further discovered a strong linear correlation between the magnitude of the energy shielding and the amplitude of the bubble-scattered acoustics, independent of the initial size and the void fraction of bubble cloud within a range addressed in the simulation. This correlation could provide for real-time monitoring of cavitation activity in BWL

International Society of Sports Nutrition position stand: beta-alanine

Position statement: The International Society of Sports Nutrition (ISSN) provides an objective and critical review of the mechanisms and use of beta-alanine supplementation. Based on the current available literature, the conclusions of the ISSN are as follows: 1) Four weeks of beta-alanine supplementation (4–6 g daily) significantly augments muscle carnosine concentrations, thereby acting as an intracellular pH buffer; 2) Beta-alanine supplementation currently appears to be safe in healthy populations at recommended doses; 3) The only reported side effect is paraesthesia (tingling), but studies indicate this can be attenuated by using divided lower doses (1.6 g) or using a sustained-release formula; 4) Daily supplementation with 4 to 6 g of beta-alanine for at least 2 to 4 weeks has been shown to improve exercise performance, with more pronounced effects in open end-point tasks/time trials lasting 1 to 4 min in duration; 5) Beta-alanine attenuates neuromuscular fatigue, particularly in older subjects, and preliminary evidence indicates that beta-alanine may improve tactical performance; 6) Combining beta-alanine with other single or multi-ingredient supplements may be advantageous when supplementation of beta-alanine is high enough (4–6 g daily) and long enough (minimum 4 weeks); 7) More research is needed to determine the effects of beta-alanine on strength, endurance performance beyond 25 min in duration, and other health-related benefits associated with carnosine

Podofilox-Induced Regression of Shope Papillomas May Be Independent of Host Immunity

We tested the hypothesis that infiltrating leukocytes might contribute to papilloma destruction following podofilox treatment. New Zealand White (NZW) rabbits were inoculated with cottontail rabbit papillomavirus (CRPV) onto abraded areas of the dorsal skin. At 21 d after viral inoculation, 5.0% podofilox solution was applied to some papillomas, whereas others were used as controls. Three rabbits were sacrificed at each of three different periods after treatment initiation (1, 4, and 7 d). Four monoclonal antibodies (MoAbs), RG-16 (for B cells), L11/135 (specific for T cells), 2C4 (specific for class II antigen), and Ki67 (specific for proliferating cells), were used in an immunohistochemical study. All positive cells and total cells in the field were counted with an ocular grid. After 1 d of treatment, proliferation of papilloma cells was strongly suppressed in treated papillomas, but leukocytic infiltration was not altered. At 4 d and 7 d of treatment, there were substantial increases (about two to three times) in the numbers of B and T cells and class II – expressing leukocytes. The upper layers of the papillomas were highly necrotic and cell proliferation was absent in an layers. These data support the view that podofilox has a direct toxic effect on papilloma tissue. Leukocyte infiltration is not strongly associated with papilloma tissue and may not contribute to papilloma destruction

Analysis of the efficacy, safety, and regulatory status of novel forms of creatine

Creatine has become one of the most popular dietary supplements in the sports nutrition market. The form of creatine that has been most extensively studied and commonly used in dietary supplements is creatine monohydrate (CM). Studies have consistently indicated that CM supplementation increases muscle creatine and phosphocreatine concentrations by approximately 15–40%, enhances anaerobic exercise capacity, and increases training volume leading to greater gains in strength, power, and muscle mass. A number of potential therapeutic benefits have also been suggested in various clinical populations. Studies have indicated that CM is not degraded during normal digestion and that nearly 99% of orally ingested CM is either taken up by muscle or excreted in urine. Further, no medically significant side effects have been reported in literature. Nevertheless, supplement manufacturers have continually introduced newer forms of creatine into the marketplace. These newer forms have been purported to have better physical and chemical properties, bioavailability, efficacy, and/or safety profiles than CM. However, there is little to no evidence that any of the newer forms of creatine are more effective and/or safer than CM whether ingested alone and/or in combination with other nutrients. In addition, whereas the safety, efficacy, and regulatory status of CM is clearly defined in almost all global markets; the safety, efficacy, and regulatory status of other forms of creatine present in today’s marketplace as a dietary or food supplement is less clear

The role of trapped bubbles in kidney stone detection with the color Doppler ultrasound twinkling artifact

The color Doppler ultrasound twinkling artifact, which highlights kidney stones with rapidly changing color, has the potential to improve stone detection; however, its inconsistent appearance has limited its clinical utility. Recently, it was proposed stable crevice bubbles on the kidney stone surface cause twinkling; however, the hypothesis is not fully accepted because the bubbles have not been directly observed. In this paper, the micron or submicron-sized bubbles predicted by the crevice bubble hypothesis are enlarged in kidney stones of five primary compositions by exposure to acoustic rarefaction pulses or hypobaric static pressures in order to simultaneously capture their appearance by high-speed photography and ultrasound imaging. On filming stones that twinkle, consecutive rarefaction pulses from a lithotripter caused some bubbles to reproducibly grow from specific locations on the stone surface, suggesting the presence of pre-existing crevice bubbles. Hyperbaric and hypobaric static pressures were found to modify the twinkling artifact; however, the simple expectation that hyperbaric exposures reduce and hypobaric pressures increase twinkling by shrinking and enlarging bubbles, respectively, largely held for rough-surfaced stones but was inadequate for smoother stones. Twinkling was found to increase or decrease in response to elevated static pressure on smooth stones, perhaps because of the compression of internal voids. These results support the crevice bubble hypothesis of twinkling and suggest the kidney stone crevices that give rise to the twinkling phenomenon may be internal as well as external

A Comparison of Absolute Overlearning on the Retention of Fast and Slow Learners

Various studies on the relation of speed of learning to retention have been reported (2) (3) (4). Many such studies are subject to the criticism that the degree of learning of fast and slow learners was not equated. Gillette (1), using the method of adjusted learning , found that fast learners retained more than slow learners as measured by both recall and relearning. Her study has set the pattern for subsequent investigation. A question may be raised, however, as to whether the degree of learning is actually equated by the method of adjusted learning. The acquisition curve for the fast learner rises at a more rapid rate than for the slow learner. Hence, when a criterion of learning is established, the training trial that achieves the criterion will carry the fast learners more above the criterion than it will the slow learners. The fast group then actually has a greater response tendency than the slow group, or the degree of learning is not equal. The present paper reports a preliminary study of an investigation designed to test the above reasoning and the further deduction that the effectiveness of overlearning on retention should vary depending on the speed of learning and should be of most value for the fast learner

Contrasting Development of Canopy Structure and Primary Production in Planted and Naturally Regenerated Red Pine Forests

Globally, planted forests are rapidly replacing naturally regenerated stands but the implications for canopy structure, carbon (C) storage, and the linkages between the two are unclear. We investigated the successional dynamics, interlinkages and mechanistic relationships between wood net primary production (NPPw) and canopy structure in planted and naturally regenerated red pine (Pinus resinosa Sol. ex Aiton) stands spanning ≥ 45 years of development. We focused our canopy structural analysis on leaf area index (LAI) and a spatially integrative, terrestrial LiDAR-based complexity measure, canopy rugosity, which is positively correlated with NPPw in several naturally regenerated forests, but which has not been investigated in planted stands. We estimated stand NPPw using a dendrochronological approach and examined whether canopy rugosity relates to light absorption and light–use efficiency. We found that canopy rugosity increased similarly with age in planted and naturally regenerated stands, despite differences in other structural features including LAI and stem density. However, the relationship between canopy rugosity and NPPw was negative in planted and not significant in naturally regenerated stands, indicating structural complexity is not a globally positive driver of NPPw. Underlying the negative NPPw-canopy rugosity relationship in planted stands was a corresponding decline in light-use efficiency, which peaked in the youngest, densely stocked stand with high LAI and low structural complexity. Even with significant differences in the developmental trajectories of canopy structure, NPPw, and light use, planted and naturally regenerated stands stored similar amounts of C in wood over a 45-year period. We conclude that widespread increases in planted forests are likely to affect age-related patterns in canopy structure and NPPw, but planted and naturally regenerated forests may function as comparable long-term C sinks via different structural and mechanistic pathways