Synthesis of Pyridazine Derivatives. XXIII. Synthesis of Isomeric Azolopyrido (3,2-d) - and Azolopyrido (2,3-d) pyridazines

The synthesis of six new parent azolopyridopyridazines (I-VI) is described. Electropnilic substitutions were studied on two isomeric imidazopyrd.dopyridazines and it was found that position 3 is attacked

Syntheses in the Pyridazine Series. XXXII. Some Investigations on Polynuclear Systems Containing a Pyridazine Ring

Some 5,6-dihydrobenzo[f]phthalazines have been aromatized to II and the structures of a number of nitro derivatives prepared from several polynuclear systems (III, IV, V) , have been established

Syntheses in the Pyridazine Series. XXXII. Some Investigations on Polynuclear Systems Containing a Pyridazine Ring

Some 5,6-dihydrobenzo[f]phthalazines have been aromatized to II and the structures of a number of nitro derivatives prepared from several polynuclear systems (III, IV, V) , have been established

QSAR of Flavonoids: 4. Differential Inhibition of Aldose Reductase and p56lck Protein Tyrosine Kinase

Flavonoids are a group of low molecular weight plant products, based on the parent compound, flavone (2-phenylchromone) and have shown potential for application in a variety of pharmacological tar-gets. By using random screening techniques flavones have been proposed as inhibitors of aldose reductase, an enzyme crucial in the treatment of diabetic complications such as cataract formation. On the other hand, a large number of natural and synthetic flavonoids are being tested as specific inhibitors of protein tyrosine kinase (PTK). Kinetic analyses of the PTK inhibition indicate that flavonoids are competitive inhibitors with respect to the nucleotide ATP A thorough investigation of the available experimental data base by using both classical and quantum Chemical descriptors has been performed in order to develop quantitative structure-activity relationships for these enzyme systems. Relevance of the descriptors to binding properties of both enzyme receptors active site is proposed and the obtained results demonstrate in detail which specific electronic as well as the hydrophobic and steric properties of the substituents play a significant role in their differential binding

Synthesis of Pyridazine Derivatives. XXIII. Synthesis of Isomeric Azolopyrido (3,2-d) - and Azolopyrido (2,3-d) pyridazines

The synthesis of six new parent azolopyridopyridazines (I-VI) is described. Electropnilic substitutions were studied on two isomeric imidazopyrd.dopyridazines and it was found that position 3 is attacked

Content of atropine and scopolamine in poisonous solanaceae plants from Slovenia

<p><strong>Background:</strong> Some species from the Solanaceae family are still the cause of serious poisoning among youth in Slovenia. Usually intoxication is due to abuse of these plants to provoke hallucinations. There is still not enough data about the alkaloid content of these plants growing in Slovenia.</p><p><strong>Methods:</strong> Different plant samples were analyzed for the content of atropine and scopolamine with capillary electrophoresis after solid phase extraction of alkaloids. Plants were gathered from different areas of Slovenia between April and September 2004.</p><p><strong>Results:</strong> Results were compared and possible correlations between the alkaloid content and species, plant parts, growth conditions, and time of harvest were suggested. Atropine and scopolamine contents were assessed in deadly nightshade (Atropa belladonna L.), thorn apple (Datura stramonium L.), scopolia (Scopolia carniolica Jacq.) and angel trumpet. The common name angel trumpet is used for Datura inoxia Mill. as well as for different Brugmansia Pers. species. The most intriguing results were the variable alkaloid content in various Brugmansia species and generally great differences in alkaloid content among various plants and their plant parts.</p><p><strong>Conclusions:</strong> All investigated plants have noticeable atropine and/or scopolamine content. The content is variable between various plants and their plant parts and therefore special care should be taken in cases of possible intoxication. It was shown that smaller or greater amounts of ingested drug can cause the same level of intoxication due to the variability in alkaloid content.</p