Fibronectin as a Root Surface Biomodifation Agent: Is it Worth it!!

ABSTRACT Various physical and chemical agents have been introduced for the modification of the root surface known as biomodification procedures in order to detoxify, decontaminate, and demineralise the root surface. Fibronectin is involved in the attachment of gingival fibroblasts to root surface, appear to offer potential for retarding epithelial down growth and hence promotes root biomodification and regeneration. With this intention in mind, EBSCO HOST was searched for entries since 1966 -2014, which included:-Journal of Periodontology, Annals of Periodontology, Periodontology 2000, Journal of Clinical Periodontology, International Journal of Periodontics and Restorative dentistry, Journal of Indian Society of Periodontology and Journal of Periodontal Research. A total of 12 studies were reviewed, out of these 12 studies, only, 6 reported evidence of regeneration for fibronectin. It was found that the role of fibronectin as a root biomodifying agent in regeneration is still unpredictable and doubtful