Replication in Genome-Wide Association Studies

Replication helps ensure that a genotype-phenotype association observed in a genome-wide association (GWA) study represents a credible association and is not a chance finding or an artifact due to uncontrolled biases. We discuss prerequisites for exact replication, issues of heterogeneity, advantages and disadvantages of different methods of data synthesis across multiple studies, frequentist vs. Bayesian inferences for replication, and challenges that arise from multi-team collaborations. While consistent replication can greatly improve the credibility of a genotype-phenotype association, it may not eliminate spurious associations due to biases shared by many studies. Conversely, lack of replication in well-powered follow-up studies usually invalidates the initially proposed association, although occasionally it may point to differences in linkage disequilibrium or effect modifiers across studies.Comment: Published in at http://dx.doi.org/10.1214/09-STS290 the Statistical Science (http://www.imstat.org/sts/) by the Institute of Mathematical Statistics (http://www.imstat.org

Improved surface quality of anisotropically etched silicon {111} planes for mm-scale integrated optics

We have studied the surface quality of millimeter-scale optical mirrors produced by etching CZ and FZ silicon wafers in potassium hydroxide to expose the $\{111\}$ planes. We find that the FZ surfaces have four times lower noise power at spatial frequencies up to $500\, {mm}^{-1}$. We conclude that mirrors made using FZ wafers have higher optical quality

Focusing on the extended X-ray emission in 3C 459 with a Chandra follow-up observation

6 pages, 4 figures. Reproduced with permission from Astronomy & Astrophysics. © 2019 ESO.Aims. We investigated the X-ray emission properties of the powerful radio galaxy 3C 459 revealed by a recent Chandra follow-up observation carried out in October 2014 with a 62 ks exposure. Methods. We performed an X-ray spectral analysis from a few selected regions on an image obtained from this observation and also compared the X-ray image with a 4.9 GHz VLA radio map available in the literature. Results. The dominant contribution comes from the radio core but significant X-ray emission is detected at larger angular separations from it, surrounding both radio jets and lobes. According to a scenario in which the extended X-ray emission is due to a plasma collisionally heated by jet-driven shocks and not magnetically dominated, we estimated its temperature to be ∼0.8 keV. This hot gas cocoon could be responsible for the radio depolarization observed in 3C 459, as recently proposed also for 3C 171 and 3C 305. On the other hand, our spectral analysis and the presence of an oxygen K edge, blueshifted at 1.23 keV, cannot exclude the possibility that the X-ray radiation originating from the inner regions of the radio galaxy could be intercepted by some outflow of absorbing material intervening along the line of sight, as already found in some BAL quasars.Peer reviewe

Buoyancy-driven inflow to a relic cold core: the gas belt in radio galaxy 3C 386

We report measurements from an XMM-Newton observation of the low-excitation radio galaxy 3C 386. The study focusses on an X-ray-emitting gas belt, which lies between and orthogonal to the radio lobes of 3C 386 and has a mean temperature of $0.94\pm0.05$ keV, cooler than the extended group atmosphere. The gas in the belt shows temperature structure with material closer to the surrounding medium being hotter than gas closer to the host galaxy. We suggest that this gas belt involves a `buoyancy-driven inflow' of part of the group-gas atmosphere where the buoyant rise of the radio lobes through the ambient medium has directed an inflow towards the relic cold core of the group. Inverse-Compton emission from the radio lobes is detected at a level consistent with a slight suppression of the magnetic field below the equipartition value.Comment: 11 pages, 10 figures, accepted for publication in MNRA

Hydrodynamics of a River Undergoing Environmental Restoration: Buffalo River, Buffalo, Ny

Due to its environmental degradation including contaminated sediment, poor water quality, and lost habitat, the lower 9.2 km of the Buffalo River is a Great Lakes Area of Concern (AoC). To better understand the river’s hydrodynamics, particularly the interaction between the downriver and upriver flow, since 2009 five horizontal and five vertical Acoustic Doppler Current Profilers (H-ADCP and V-ADCP, respectively) have been deployed year round in the lower 9km of the Buffalo River. The ADCPs were programmed to take measurements every 15 (H-ADCPs) or 20 minutes (V-ADCPs). Data were processed to ensure integrity and permit temporal changes to be investigated. During the period of ADCP deployment, the Buffalo River has undergone dredging, including a large-scale environmental dredging project which widened and deepened some sections of the river\u27s channel. ADCP measurements document several different flow behaviors including high flow events related to runoff from snowmelt and high precipitation and flow reversals related to the upriver propagation of Lake Erie wind-driven surges. River velocities generally are low (~10cm/s), but may reach up to 2 m/s during high flow events. The Buffalo River also has its own periodic (~1.75 - 2 hr) oscillation (river seiche) that is best observed during times of non-lake surge activity or low downstream velocities. The river seiche persists year round during open as well as ice-covered conditions. Keywords: River, Hydrodynamics, ADCPs, Seiche, Restoration

Stage to Studio

Award for Best Research in the Field of Record Labels or Manufacturers from the Association for Recorded Sound CollectionsWinner of the Kenneth W. Baldridge Prize from the Phi Alpha Theta Honor Society, Hawaii Region Between the late nineteenth and mid-twentieth century, technology transformed the entertainment industry as much as it did such heavy industries as coal and steel. Among those most directly affected were musicians, who had to adapt to successive inventions and refinements in audio technology—from wax cylinders and gramophones to radio and sound films. In this groundbreaking study, James P. Kraft explores the intersection of sound technology, corporate power, and artistic labor during this disruptive period.Kraft begins in the late nineteenth century's "golden age" of musicians, when demand for skilled instrumentalists often exceeded supply, analyzing the conflicts in concert halls, nightclubs, recording studios, radio stations, and Hollywood studios as musicians began to compete not only against their local counterparts but also against highly skilled workers in national "entertainment factories." Kraft offers an illuminating case study in the impact of technology on industry and society—and a provocative chapter in the cultural history of America

Vegas at Odds

The stories of the shadowy networks and wealthy people who bankrolled and sustained Las Vegas's continuous reinvention are well documented in works of scholarship, journalism, and popular culture. Yet no one has studied closely and over a long period of time the dynamics of the workforce—the casino and hotel workers and their relations with the companies they work for and occasionally strike against. James P. Kraft here explores the rise and changing fortunes of organized and unorganized labor as Las Vegas evolved from a small, somewhat seedy desert oasis into the glitzy tourist destination that it is today.Drawing on scores of interviews, personal and published accounts, and public records, Kraft brings to life the largely behind-the-scenes battles over control of Sin City workplaces between 1960 and 1985. He examines successful and failed organizing drives, struggles over pay and equal rights, and worker grievances and arbitration to show how the resort industry’s evolution affected hotel and casino workers. From changes in the political and economic climate to large-scale strikes, backroom negotiations, and individual worker-supervisor confrontations, Kraft explains how Vegas's overwhelmingly service-oriented economy works—and doesn't work—for the people and companies who cater to the city's pleasure-seeking visitors.American historians and anyone interested in the history of labor or Las Vegas will find this account highly original, insightful, and even-handed